Design, synthesis and biological evaluation of nuclear receptor-degradation inducers

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 22, 2011, Pages 6768-6778

  Itoh, Yukihiro ^a   Kitaguchi, Risa ^a   Ishikawa, Minoru ^a   Naito, Mikihiko ^b   Hashimoto, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

AR; ER; Protein degradation inducer; Protein knockdown; RAR

Indexed keywords

(10,13 DIMETHYL 3 OXOHEXADEXAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 17 YL) 18 AMINO 17 HYDROXY 14 ISOBUTYL 13,15 DIOXO 19 PHENYL 3.6.9 TRIOXA 12,15 DIAZANONADECAN 1 OATE; 2 (3 AMINO 2 HYDROXY 4 PHENYLBUTANAMIDO) N [2 [2 [2 [2 [[(3 HYDROXY 13 METHYL 7,8,9,11,12,13,15,16 OCTAHYDRO 6H CYCLOPENTA[A]PHENANTHREN 17(14H) YLIDENE)AMINO]OXY]ACETAMIDO]ETHOXY]ETHOXY]ETHYL] 4 METHYLPENTANAMIDE; 2 [3 [2 [2 [2 [2 [2 (3 AMINO 2 HYDROXY 4 PHENYLBUTANAMIDO) 4 METHYLPENTANAMIDO]ETHOXY]ETHOXY]ETHOXY]ACETAMIDO]PROPOXY] 4 [3 (3,5 DI TERT BUTYLPHENYL) 3 OXOPROP 1 ENYL]BENZOIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR SPECIFIC AND NONGENETIC INHIBITOR OF APOPTOSIS PROTEIN DEPENDENT PROTEIN ERASER DERIVATIVE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR SPECIFIC AND NONGENETIC INHIBITOR OF APOPTOSIS PROTEIN DEPENDENT PROTEIN ERASER DERIVATIVE; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR SPECIFIC AND NONGENETIC INHIBITOR OF APOPTOSIS PROTEIN DEPENDENT PROTEIN ERASER DERIVATIVE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN DEGRADATION;

DRUG DESIGN; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LIGANDS; RECEPTORS, ANDROGEN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; UBIQUITINATION;

INTRACISTERNAL A-PARTICLES;

EID: 80054969919     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.041     Document Type: Conference Paper

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