Development of target protein-selective degradation inducer for protein knockdown

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 10, 2011, Pages 3229-3241

  Itoh, Yukihiro ^a   Ishikawa, Minoru ^a   Kitaguchi, Risa ^a   Sato, Shinichi ^a   Naito, Mikihiko ^b   Hashimoto, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

CRABP II; IAPs; Protein degradation inducer; Protein knockdown

Indexed keywords

(9H FLUOREN 9 YL)METHYL 4 [1 [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYLAMINO] 4 METHYL 1 OXOPENTAN 2 YLAMINO] 3 HYDROXY 4 OXO 1 PHENYLBUTAN 2 YLCARBAMATE; 2 [1 (DIMETHYLAMINO)NAPHTHALENE 5 SULFONAMIDO]ETHYL 2 [3 (TERT BUTOXYCARBONYL) 2 HYDROXY 4 PHENYLBUTANAMIDO] 4 METHYLPENTANOATE; 2 [1 (DIMETHYLAMINO)NAPHTHALENE 5 SULFONAMIDO]ETHYL 2 [3 AMINO 2 HYDROXY 4 PHENYLBUTANAMIDO] 4 METHYLPENTANOATE; 2 [3 (TERT BUTOXYCARBONYL) 2 HYDROXY 4 PHENYLBUTANAMIDO] 4 METHYLPENTANOIC ACID; 2 [3 AMINO 2 HYDROXY 4 PHENYLBUTANAMIDO] N 4 DIMETHYLPENTANAMIDE; 2 CYANOETHYL 3,7 DIMETHYL 9 [2,6,6 TRIMETHYL 3 [2 [2 [2 [2 [4 METHYL 2 (4 PHENYLBUTANAMIDO)PENTANAMIDO]ETHOXY]ETHOXY]ETHYLAMINO] 2 OXOETHOXYIMINO]CYCLOHEX 1 ENYL]NONA 2,4,6,8 TETRAENOATE; 2 CYANOETHYL 9 [3 [2 [2 [2 [2 [2 [3 [[(9H FLUOREN 9 YL)METHOXY]CARBONYL] 2 HYDROXY 4 PHENYLBUTANAMIDO] 4 METHYLPENTANAMIDO]ETHOXY]ETHOXY]ETHYLAMINO] 2 OXOETHOXYIMINO] 2,6,6 TRIMETHYLCYCLOHEX 1 ENYL] 3,7 DIMETHYLNONA 2,4,6,8 TETRAENOATE; 2 ISOBUTYL 4 OXO 7 PHENYLPENTANOIC ACID; 3,7 DIMETHYL 9 [2,6,6 TRIMETHYL 3 [2 [2 [2 [2 [4 METHYL 2 (4 PHENYLBUTANAMIDO)PENTANAMIDO]ETHOXY]ETHOXY]ETHYLAMINO] 2 OXOETHOXYIMINO]CYCLOHEX 1 ENYL]NONA 2,4,6,8 TETRAENOIC ACID; 5 (DIMETHYLAMINO) N (2 HYDROXYETHYL)NAPHTHALENE 1 SULFONAMIDE; 9 [3 [2 [2 [2 [2 [2 (3 AMINO 2 HYDROXY 4 PHENYLBUTANAMIDO) 4 METHYLPENTANAMIDO]ETHOXY]ETHOXY]ETHYLAMINO] 2 OXOETHOXYIMINO] 2,6,6 TRIMETHYLCYCLOHEX 1 ENYL] 3,7 DIMETHYLNONA 2,4,6,8 TETRAENOIC ACID; BESTATIN; CELLULAR RETINOIC ACID BINDING PROTEIN II; METHYL 4 METHYL 2 (4 PHENYLBUTANAMIDO)PENTANOATE; N [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYL] 4 METHYL 2 (4 PHENYLBUTANAMIDO)PENTANAMIDE; N,4 DIMETHYL 2 (4 PHENYLBUTANAMIDO)PENTANAMIDE; RETINOIC ACID BINDING PROTEIN; TERT BUTYL 2 [2 (2 AMINOETHOXY)ETHOXY]ETHYLCARBAMATE; TERT BUTYL 2 [2 (2 AZIDOETHOXY)ETHOXY]ETHYLCARBAMATE; TERT BUTYL 2 [2 [2 [4 METHYL 2 (4 PHENYLBUTANAMIDO)PENTANAMIDO]ETHOXY]ETHOXY]ETHYLCARBAMATE; TERT BUTYL 3 HYDROXY 4 [4 METHYL 1 (METHYLAMINO) 1 OXOPENTAN 2 YLAMINO] 4 OXO 1 PHENYLBUTAN 2 YLCARBAMATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN TARGETING; SYNTHESIS; UBIQUITINATION;

AMIDES; CELL LINE; CELL LINE, TUMOR; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; NEUROBLASTOMA; RECEPTORS, RETINOIC ACID; SMALL MOLECULE LIBRARIES;

INTRACISTERNAL A-PARTICLES;

EID: 79956220945     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.057     Document Type: Article

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