Small molecules destabilize cIAP1 by activating auto-ubiquitylation

Journal of Biological Chemistry

Volumn 283, Issue 14, 2008, Pages 8961-8968

  Sekine, Keiko ^a,b   Takubo, Kohei ^a   Kikuchi, Ryo ^a   Nishimoto, Michie ^a   Kitagawa, Masayuki ^b   Abe, Fuminori ^b   Nishikawa, Kiyohiro ^b   Tsuruo, Takashi ^a,c   Naito, Mikihiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIPPON KAYAKU CO LTD   (Japan)

^c CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC PROTEINS; CANCER CELLS; CERVICAL CANCERS; DO-MAINS; ESOPHAGEAL SQUAMOUS CELL CARCINOMATA; HEPATOCELLULAR CARCINOMATA; LIGASE ACTIVITIES; LUNG CANCERS; METHYL ESTERS; NOVEL METHODS; NOVEL STRATEGIES; OVEREXPRESSION; PROTEASOMAL DEGRADATIONS; SMALL MOLECULES; UBIQUITIN; UBIQUITYLATION;

AMINES; AMINO ACIDS; AMPLIFICATION; CELL DEATH; CHEMOTHERAPY; COMPOSITE MICROMECHANICS; ESTERS;

MOLECULES;

ESTER DERIVATIVE; INHIBITOR OF APOPTOSIS PROTEIN 1; LIGASE; N [3 AMINO 2 HYDROXY 4 PHENYL BUTYRYL] LEVO LEUCINE METHYL ESTER; PROTEASOME; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; ( ) N ((2S,3R) 3 AMINO 2 HYDROXY 4 PHENYL BUTYRYL) L LEUCINE METHYL ESTER; (-)-N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYL)-L-LEUCINE METHYL ESTER; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; INHIBITOR OF APOPTOSIS PROTEIN; LEUCINE; UBIQUITIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER THERAPY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; RING FINGER MOTIF; SENSITIZATION; UBIQUITINATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; GENE EXPRESSION REGULATION; HELA CELL; METABOLISM; NEOPLASM; PROTEIN TERTIARY STRUCTURE;

INTRACISTERNAL A-PARTICLES;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LEUCINE; NEOPLASMS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; UBIQUITIN; UBIQUITINATION;

EID: 44049087791     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709525200     Document Type: Article

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