Solid-state solubility influences encapsulation and release of hydrophobic drugs from PLGA/PLA nanoparticles

Journal of Pharmaceutical Sciences

Volumn 93, Issue 7, 2004, Pages 1804-1814

  Panyam, Jayanth ^a   William, Deborah ^b   Dash, Alekha ^c   Leslie Pelecky, Diandra ^b   Labhasetwar, Vinod ^a,d  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Biodegradable polymers; Dexamethasone; Differential scanning calorimetry; Particle size; Preformulation parameter; Sustained release; X ray powder diffraction

Indexed keywords

CARBOXYL GROUP; DEXAMETHASONE; ESTER; FLUTAMIDE; FUNCTIONAL GROUP; NANOPARTICLE; POLYGLACTIN; POLYLACTIDE; POLYMER; SOLVENT;

ARTICLE; BIODEGRADABILITY; CHEMICAL COMPOSITION; CORRELATION ANALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; EMULSION; ENCAPSULATION; EVAPORATION; HYDROPHOBICITY; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL PHASE; PREFORMULATION; SOLID STATE; SUSTAINED RELEASE PREPARATION; X RAY POWDER DIFFRACTION;

EID: 3042601972     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20094     Document Type: Article

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