Synthesis and biological activities of triazole derivatives as inhibitors of InhA and antituberculosis agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5524-5531

  Menendez, Christophe ^a,b   Gau, Sylvain ^a,b   Lherbet, Christian ^a,b   Rodriguez, Frédéric ^a,b   Inard, Cyril ^c   Pasca, Maria Rosalia ^d   Baltas, Michel ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c INSTITUT CLAUDIUS REGAUD   (France)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

Enoyl ACP reductase; InhA; Inhibitor; Triazole; Tuberculosis

Indexed keywords

1 (1 (3 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL) 2 (2,4 DICHLOROPHENYL)ETHANONE; 1 (1 (3,5 DIMETHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL) 2 (2,4 DICHLOROPHENYL)ETHANONE; 1 (1 (3,5 DIMETHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL) 2 PHENYLETHANONE; 1 (1 (3,5 DIMETHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL) 2 (2,4 DICHLOROPHENYL)ETHANONE; 1 (1 (3,5 DIMETHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL) 2 PHENYLETHANONE; 1 (1 (4 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL) 2 PHENYLETHANONE; 1 (1 (CYCLOHEXYLMETHYL) 1H 1,2,3 TRIAZOL 4 YL) 2 PHENYLETHANONE; 1 (1 (OCTYL) 1H 1,2,3 TRIAZOL 4 YL) 2 PHENYLETHANONE; 1 (1 BENZYL 1H 1,2,3 TRIAZOL 4 YL) 2 (2,4 DICHLOROPHENYL)ETHANONE; 1 (1 BENZYL 1H 1,2,3 TRIAZOL 4 YL) 2 PHENYLETHANONE; 1 (1 OCTYL) 1H1,2,3 TRIAZOL 4 YL 2 PHENYLETHANOL; 1 (1(3 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL) 2 PHENYLETHANONE; 1 (1(4 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL) 2 (2,4 DICHLOROPHENYL)ETHANONE; 1 (3 METHOXYBENZYL) 4 PHENETHYL 1H 1,2,3 TRIAZOLE; 1 (3,5 DIMETHYLBENZYL) 4 PHENETHYL 1H 1,2,3 TRIAZOLE; 1 (CYCLOHEXYLMETHYL) 4 PHENYL 1H 1,2,3 TRIAZOLE; 1 (OCTYL) 4 PHENETHYL 1H 1,2,3 TRIAZOLE; 1 DODECYL 4 PHENETHYL 1H 1,2,3 TRIAZOLE; 1 NONYL 4 PHENETHYL 1H 1,2,3 TRIAZOLE; 2 (2,4 DICHLOROPHENYL) 1 (1 OCTYL 1H 1,2,3 TRIAZOL 4 YL)ETHANONE; 2 (2,4 DICHLOROPHENYL) 1 (1 OCTYL 1H 1,2,3 TRIAZOYL 4 YL)ETHANOL; TRIAZOLE DERIVATIVE; TRICLOSAN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLOADDITION; DRUG SCREENING; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; TRIAZOLES; TRICLOSAN;

EID: 80054914442     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.013     Document Type: Article

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