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Volumn 5, Issue 19, 2003, Pages 3451-3454

New Entry to a Three-Component Pyrimidine Synthesis by TMS-Ynones via Sonogashira Coupling

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE; ALDEHYDE DERIVATIVE; CHLORIDE; KETONE DERIVATIVE; PYRIMIDINE; TRIETHYLAMINE;

EID: 0344392791     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol035212q     Document Type: Article
Times cited : (239)

References (44)
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    • note
    • Unfortunately, we could not reproduce the copper-catalyzed reaction of p-methylbenzoyl chloride with (TMS)-acetylene in dry triethylamine under nitrogen at room temperature as claimed in ref 15.
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    • note
    • 3Si, 260.0864; found, 260.0881.
  • 41
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    • note
    • 13C, and NOESY NMR. These assignments are additionally supported by IR and MS spectra, as well as correct elemental analyses.
  • 42
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    • note
    • 2OS (268.3): C, 67.14; H, 4.51; N, 10.44. Found: C, 66.78; H, 4.51; N, 10.29.
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    • For the significance of 2,4-disubstituted pyrimidines as tyrosine kinase inhibitors see, e.g.: (a) Traxler, P.; Bold, G.; Buchdunger, E.; Caravatti, G.; Furet, P.; Manley, P.; O'Reilly, T.; Wood, J.; Zimmermann, J. Med. Res. Rev. 2001, 21, 499. (b) Zimmermann, J.; Buchdunger, E.; Mett, H.; Meyer, T.; Lydon, N. B. Bioorg. Med. Chem. Lett. 1997, 7, 187.
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