Triclosan derivatives: Towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis

ChemMedChem

Volumn 4, Issue 2, 2009, Pages 241-248

  Freundlich, Joel S ^a,c   Wang, Feng ^b,d   Vilchèze, Catherine ^b   Gulten, Gulcin ^a   Langley, Robert ^a   Schiehser, Guy A ^c   Jacobus, David P ^c   Jacobs Jr , William R ^b   Sacchettini, James C ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c Jacobus Pharmaceutical Co Inc   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Antibiotics; Drug resistance; Fatty acids; Triclosan; Tuberculosis

Indexed keywords

ALKYL GROUP; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); ISONIAZID; MYCOLIC ACID; OXIDOREDUCTASE INHIBITOR; TRICLOSAN; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIOLYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FATTY ACID SYNTHESIS; IC 50; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TRICLOSAN;

EID: 60849124512     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800261     Document Type: Article

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