Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation

Journal of Neuropathology and Experimental Neurology

Volumn 70, Issue 11, 2011, Pages 1020-1035

  Guemez Gamboa, Alicia ^a   Estrada Sánchez, Ana María ^a   Montiel, Teresa ^a   Páramo, Blanca ^a   Massieu, Lourdes ^a   Morán, Julio ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Calpain; Excitotoxicity; Glutamate receptors; NADPH oxidase; Oxidative damage; Striatum

Indexed keywords

CALPAIN; GLUTAMIC ACID; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; EXCITOTOXICITY; IMMUNOREACTIVITY; IN VIVO STUDY; MOUSE; NEUROTOXICITY; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; CALCIUM-BINDING PROTEINS; CALPAIN; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGENTS; GENE EXPRESSION REGULATION; GLUTAMIC ACID; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MICROGLIA; NADPH OXIDASE; NEURONS; NEUROTOXICITY SYNDROMES; ORGANIC CHEMICALS; PHOSPHOPYRUVATE HYDRATASE; REACTIVE OXYGEN SPECIES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, IONOTROPIC GLUTAMATE; RECEPTORS, METABOTROPIC GLUTAMATE; TIME FACTORS;

EID: 80054890113     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3182358e4e     Document Type: Article

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