Evidence group I mGluR drugs modulate the activation profile of lipopolysaccharide-exposed microglia in culture

Neurochemical Research

Volumn 34, Issue 10, 2009, Pages 1721-1728

  Farso, Mark C ^a,b   O'Shea, Ross D ^a   Beart, Philip M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

Author keywords

(S) 3,5 DHPG; Anti inflammatory; Group I mGluR; LPS; Microglia

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 3,5 DIHYDROXYPHENYLGLYCINE; GLUTAMIC ACID; LIPOPOLYSACCHARIDE; METABOTROPIC RECEPTOR; NITRITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL POPULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; IMAGE ANALYSIS; MICROGLIA; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DRUG SYNERGISM; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; LIGANDS; LIPOPOLYSACCHARIDES; MICROGLIA; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RESORCINOLS; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 69049103020     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-9999-3     Document Type: Article

References (34)

1. UK Hanisch H Kettenmann 2007 Microglia: active sensor and versatile effector cells in the normal and pathologic brain Nat Neurosci 10 1387 1394 10.1038/nn1997
2. C Schwab PL McGeer 2008 Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders J Alzheimers Dis 13 359 369
3. GA Garden T Moller 2006 Microglia biology in health and disease J Neuroimmune Pharmacol 1 127 137 10.1007/s11481-006-9015-5
4. JM Pocock H Kettenmann 2007 Neurotransmitter receptors on microglia Trends Neurosci 30 527 535 10.1016/j.tins.2007.07.007
5. ML Block L Zecca JS Hong 2007 Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Nat Rev Neurosci 8 57 69 10.1038/nrn2038
6. CM Matute M Domercq MV Sanchez-Gomez 2006 Glutamate-mediated glial injury: mechanisms and clinical importance Glia 53 212 224 10.1002/glia.20275
7. DD Schoepp 2001 Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system J Pharmacol Exp Ther 299 12 20
8. PJ Conn JP Pin 1997 Pharmacology and functions of metabotropic glutamate receptors Annu Rev Pharmacol Toxicol 37 205 237 10.1146/annurev.pharmtox.37.1. 205
9. J Cartmell DD Schoepp 2000 Regulation of neurotransmitter release by metabotropic glutamate receptors J Neurochem 75 889 907 10.1046/j.1471-4159. 2000.0750889.x
10. S D'Antoni A Berretta CM Bonaccorso, et al. 2008 Metabotropic glutamate receptors in glial cells Neurochem Res 33 2436 2443 10.1007/s11064-008-9694-9
11. A Verkhratsky F Kirchhoff 2007 Glutamate-mediated neuronal-glial transmission J Anat 210 651 660 10.1111/j.1469-7580.2007.00734.x
12. KR Byrnes B Stoica DJ Loane, et al. 2009 Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity Glia 57 550 560 10.1002/glia.20783
13. DL Taylor LT Diemel ML Cuzner, et al. 2002 Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease J Neurochem 82 1179 1191 10.1046/j.1471-4159.2002.01062.x
14. DL Taylor LT Diemel JM Pocock 2003 Activation of group III metabotropic glutamate receptors protects neurones against microglial neurotoxicity J Neurosci 23 2150 2160
15. K Biber DJ Laurie A Berthele, et al. 1999 Expression and signalling of group I metabotropic glutamate receptors in astrocytes and microglia J Neurochem 72 1671 1680 10.1046/j.1471-4159.1999.721671.x
16. JJ Geurts G Wolswijk L Bo, et al. 2003 Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis Brain 126 1755 1766 10.1093/brain/awg179
17. DD Schoepp J Goldsworthy BG Johnson, et al. 1994 3-5- dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus J Neurochem 63 769 772
18. MC Farso RD O'Shea B Jarrott, et al. 2008 Group I mGluRs reduce the activation profile of lipopolysaccharide-exposed microglial cultures Neuropharmacology 55 595
19. RD O'Shea CL Lau MC Farso, et al. 2006 Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: evidence for delayed up-regulation and redistribution of GLT-1 Neurochem Int 48 604 610
20. M Ankarcrona JM Dypbukt E Bonfoco, et al. 1995 Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function Neuron 15 961 973 10.1016/0896-6273(95)90186-8
21. LY Kong BC Wilson MK McMillian, et al. 1996 The effects of HIV-1 envelope protein gp120 on the production of nitric oxide and proinflammatory cytokines in mixed glial cell cultures Cell Immunol 172 77 83 10.1006/cimm.1996.0217
22. WY Ong VJ Balcar 1997 Group I metabotropic glutamate receptor agonist causes neurodegeneration in rat hippocampus J Hirnforsch 38 317 322
23. RB Rock PK Peterson 2006 Microglia as a pharmacological target in infectious and inflammatory diseases of the brain J Neuroimmune Pharmacol 1 117 126 10.1007/s11481-006-9012-8
24. UK Hanisch 2002 Microglia as a source and target of cytokines Glia 40 140 155 10.1002/glia.10161
25. P Bezzi M Domercq L Brambilla, et al. 2001 CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity Nat Neurosci 4 702 710 10.1038/89490
26. CC Chao S Hu TW Molitor, et al. 1992 Activated microglia mediate neuronal cell injury via a nitric oxide mechanism J Immunol 149 2736 2741
27. C Eskes L Juillerat-Jeanneret G Leuba, et al. 2003 Involvement of microglia-neuron interactions in the tumor necrosis factor-alpha release, microglial activation, and neurodegeneration induced by trimethyltin J Neurosci Res 71 583 590 10.1002/jnr.10508
28. HM Gibbons M Dragunow 2006 Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide Brain Res 1084 1 15 10.1016/j.brainres.2006.02.032
29. D Piani K Frei KQ Do 1991 Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate Neurosci Lett 133 159 162 10.1016/0304-3940(91)90559-C
30. D Piani M Spranger K Frei 1992 Macrophage-induced cytotoxicity of N-methyl-d-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines Eur J Immunol 22 2429 2436 10.1002/eji.1830220936
31. E Abd-el-Basset S Fedoroff 1995 Effect of bacterial wall lipopolysaccharide (LPS) on morphology, motility, and cytoskeletal organization of microglia in cultures J Neurosci Res 41 222 237 10.1002/jnr.490410210
32. 2+ elevation associated with age-dependent excitotoxicity Neuroscience 112 183 194 10.1016/S0306-4522(02)00002-7
33. U Strasser D Lobner MM Behrens, et al. 1998 Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures Eur J NeuroSci 10 2848 2855 10.1111/j.1460-9568.1998.00291.x
34. YF Jiang-Shieh KY Yeh IH Wei 2005 Responses of microglia in vitro to the gram-positive bacterial component, lipoteichoic acid J Neurosci Res 82 515 524 10.1002/jnr.20663