Upregulation of interferon-γ and interleukin-4, Th cell-derived cytokines by So-Shi-Ho-Tang (Sho-Saiko-To) occurs at the level of antigen presenting cells, but not CD4 T cells

Journal of Ethnopharmacology

Volumn 123, Issue 1, 2009, Pages 6-14

  Kang, Hee ^a   Choi, Tae Won ^a   Ahn, Kyoo Seok ^a   Lee, Ju Young ^a   Ham, In Hye ^a   Choi, Ho Young ^a   Shim, Eun Sheb ^a   Sohn, Nak Won ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Antigen presenting cells; IFN ; IL 4; Sho Saiko To; So Shi Ho Tang

Indexed keywords

BAICALIN; CD3 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; MONOCLONAL ANTIBODY CD28; MONOCLONAL ANTIBODY CD3; STAT4 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR C MAF; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; XIAO CHAI HU TANG;

ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DEGENERATION; CELL MATURATION; CELL MEMBRANE PERMEABILITY; CELL MOTION; CELL PROLIFERATION; CELLULAR IMMUNITY; CHRONIC DISEASE; CHRONIC LIVER DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HERB; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMORAL IMMUNITY; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INFECTION; JAPANESE; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; STEM CELL; TH1 CELL; TH2 CELL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIGEN-PRESENTING CELLS; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; INTERFERON-GAMMA; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH1 CELLS; TH2 CELLS; UP-REGULATION;

MUS;

EID: 64549128148     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.02.045     Document Type: Article

References (44)

1. Avni O., Lee D., Macian F., Szabo S.J., Glimcher L.H., and Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nature Immunology 3 (2002) 643-651
2. Bach E.A., Aguet M., and Schreiber R.D. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annual Review of Immunology 15 (1997) 563-591
3. Baus E., Andris F., Dubois P.M., Urbain J., and Leo O. Dexamethasone inhibits the early steps of antigen receptor signaling in activated T lymphocytes. Journal of Immunology 156 (1996) 4555-4561
4. Borchers A.T., Sakai S., Henderson G.L., Harkey M.R., Keen C.L., Stern J.S., Terasawa K., and Gershwin M.E. Shosaiko-to and other Kampo (Japanese herbal) medicines: a review of their immunomodulatory activities. Journal of Ethnopharmacology 73 (2000) 1-13
5. Call M.E., and Wucherpfennig K.W. The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annual Review of Immunology 23 (2005) 101-125
6. Chang J.S., Wang K.C., Liu H.W., Chen M.C., Chiang L.C., and Lin C.C. Sho-saiko-to (Xiao-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line. American Journal of Chinese Medicine 35 (2007) 341-351
7. Cheng P.W., Ng L.T., and Lin C.C. Xiao chai hu tang inhibits CVB1 virus infection of CCFS-1 cells through the induction of Type I interferon expression. International Immunopharmacology 6 (2006) 1003-1012
8. Cho S.S., Bacon C.M., Sudarshan C., Rees R.C., Finbloom D., Pine R., and O'Shea J.J. Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. Journal of Immunology 157 (1996) 4781-4789
9. Finkelman F.D., Morris S.C., Orekhova T., Mori M., Donaldson D., Reiner S.L., Reilly N.L., Schopf L., and Urban Jr. J.F. Stat6 regulation of in vivo IL-4 responses. Journal of Immunology 164 (2000) 2303-2310
10. Grewal I.S., and Flavell R.A. CD40 and CD154 in cell-mediated immunity. Annual Review of Immunology 16 (1998) 111-135
11. Grogan J.L., Mohrs M., Harmon B., Lacy D.A., Sedat J.W., and Locksley R.M. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14 (2001) 205-215
12. Ho I.C., Lo D., and Glimcher L.H. c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. Journal of Experimental Medicine 188 (1998) 1859-1866
13. Kakumu S., Yoshioka K., Wakita T., and Ishikawa T. Effects of TJ-9 Sho-saiko-to (kampo medicine) on interferon gamma and antibody production specific for hepatitis B virus antigen in patients with type B chronic hepatitis. International Journal of Immunopharmacology 13 (1991) 141-146
14. Kawakita T., Nakai S., Kumazawa Y., Miura O., Yumioka E., and Nomoto K. Induction of interferon after administration of a traditional Chinese medicine, xiao-chai-hu-tang (shosaiko-to). International Journal of Immunopharmacology 12 (1990) 515-521
15. Kayano K., Sakaida I., Uchida K., and Okita K. Inhibitory effects of the herbal medicine Sho-saiko-to (TJ-9) on cell proliferation and procollagen gene expressions in cultured rat hepatic stellate cells. Journal of Hepatology 29 (1998) 642-649
16. Kim J.I., Ho I.C., Grusby M.J., and Glimcher L.H. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 10 (1999) 745-751
17. Krakauer T., Li B.Q., and Young H.A. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. FEBS Letters 500 (2001) 52-55
18. Lenschow D.J., Walunas T.L., and Bluestone J.A. CD28/B7 system of T cell costimulation. Annual Review of Immunology 14 (1996) 233-258
19. Leonard W.J., and O'Shea J.J. Jaks and STATs: biological implications. Annual Review of Immunology 16 (1998) 293-322
20. Lighvani A., Frucht D., Jankovic D., Yamane H., Aliberti J., Hissong B., Nguyen B., Gadina M., Sher A., Paul W., and O'Shea J. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proceedings of the National Academy of Sciences of the United States of America 18 (2001) 15137-15142
21. Matsuura K., Kawakita T., Nakai S., Saito Y., Suzuki A., and Nomoto K. Role of B-lymphocytes in the immunopharmacological effects of a traditional Chinese medicine, xiao-chai-hu-tang (shosaiko-to). International Journal of Immunopharmacology 15 (1993) 237-243
22. Monick M.M., Samavati L., Butler N.S., Mohning M., Powers L.S., Yarovinsky T., Spitz D.R., and Hunninghake G.W. Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. Journal of Immunology 171 (2003) 5107-5115
23. Moriggl R., Kristofic C., Kinzel B., Volarevic S., Groner B., and Brinkmann V. Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4. Journal of Immunology 160 (1998) 3385-3392
24. Mosmann T.R., and Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology 7 (1989) 145-173
25. Mullen A.C., High F.A., Hutchins A.S., Lee H.W., Villarino A.V., Livingston D.M., Kung A.L., Cereb N., Yao T.P., Yang S.Y., and Reiner S.L. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292 (2001) 1907-1910
26. Ohtake N., Yamamoto M., Takeda S., Aburada M., Ishige A., Watanabe K., and Inoue M. The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation. European Journal of Pharmacology 507 (2005) 301-310
27. Pien G.C., Nguyen K.B., Malmgaard L., Satoskar A.R., and Biron C.A. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. Journal of Immunology 169 (2002) 5827-5837
28. Rao A., and Avni O. Molecular aspects of T-cell differentiation. British Medical Bulletin 56 (2000) 969-984
29. Rengarajan J., Szabo S.J., and Glimcher L.H. Transcriptional regulation of Th1/Th2 polarization. Immunology Today 21 (2000) 479-483
30. Rincon M., Anguita J., Nakamura T., Fikrig E., and Flavell R.A. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. Journal of Experimental Medicine 185 (1997) 461-469
31. Sakaida I., Hironaka K., Kimura T., Terai S., Yamasaki T., and Okita K. Herbal medicine Sho-saiko-to (TJ-9) increases expression matrix metalloproteinases (MMPs) with reduced expression of tissue inhibitor of metalloproteinases (TIMPs) in rat stellate cell. Life Science 74 (2004) 2251-2263
32. Sakaida I., Matsumura Y., Akiyama S., Hayashi K., Ishige A., and Okita K. Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient l-amino acid-defined diet. Journal of Hepatology 28 (1998) 298-306
33. Schroder K., Hertzog P.J., Ravasi T., and Hume D.A. Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology 75 (2004) 163-189
34. Scott D.E., Gause W.C., Finkelman F.D., and Steinberg A.D. Anti-CD3 antibody induces rapid expression of cytokine genes in vivo. Journal of Immunology 145 (1990) 2183-2188
35. Sherman M.A., Secor V.H., Lee S.K., Lopez R.D., and Brown M.A. STAT6-independent production of IL-4 by mast cells. European Journal of Immunology 29 (1999) 1235-1242
36. Shimoda K., van Deursen J., Sangster M.Y., Sarawar S.R., Carson R.T., Tripp R.A., Chu C., Quelle F.W., Nosaka T., Vignali D.A., Doherty P.C., Grosveld G., Paul W.E., and Ihle J.N. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380 (1996) 630-633
37. Shiota G., Maeta Y., Mukoyama T., Yanagidani A., Udagawa A., Oyama K., Yashima K., Kishimoto Y., Nakai Y., Miura T., Ito H., Murawaki Y., and Kawasaki H. Effects of Sho-Saiko-to on hepatocarcinogenesis and 8-hydroxy-2′-deoxyguanosine formation. Hepatology 35 (2002) 1125-1133
38. Szabo S.J., Glimcher L.H., and Ho I.C. Genes that regulate interleukin-4 expression in T cells. Current Opinion in Immunology 9 (1997) 776-781
39. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., and Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-669
40. Tajiri H., Kozaiwa K., Ozaki Y., Miki K., Shimuzu K., and Okada S. Effect of sho-saiko-to (xiao-chai-hu-tang) on HBeAg clearance in children with chronic hepatitis B virus infection and with sustained liver disease. American Journal of Chinese Medicine 19 (1991) 121-129
41. Yamashiki M., Kosaka Y., Nishimura A., Takase K., and Ichida F. Efficacy of a herbal medicine "sho-saiko-to" on the improvement of impaired cytokine production of peripheral blood mononuclear cells in patients with chronic viral hepatitis. Journal of Clinical and Laboratory Immunology 37 (1992) 111-121
42. Yamashiki M., Nishimura A., Huang X.X., Nobori T., Sakaguchi S., and Suzuki H. Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on interleukin-12 production in patients with HCV-positive liver cirrhosis. Developmental Immunology 7 (1999) 17-22
43. Yamashiki M., Nishimura A., Nomoto M., Suzuki H., and Kosaka Y. Herbal medicine 'Sho-saiko-to' induces tumour necrosis factor-alpha and granulocyte colony-stimulating factor in vitro in peripheral blood mononuclear cells of patients with hepatocellular carcinoma. Journal of Gastroenterology and Hepatology 11 (1996) 137-142
44. Zheng W., and Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997) 587-596