Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs

Journal of Ethnopharmacology

Volumn 124, Issue 2, 2009, Pages 257-262

  Peng, Jian ^a   Qi, Qi ^a   You, Qidong ^a   Hu, Rong ^a   Liu, Wenyuan ^a   Feng, Feng ^a   Wang, Guangji ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anticancer agent; Beagle dog; Pharmacokinetic; Scutellaria baicalensis Georgi; Subchronic toxicity; Wogonin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; WOGONIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CHEMISTRY; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DISTRIBUTION VOLUME; DOG; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; FEMALE; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGY; MALE; MOUTH EDEMA; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; TOXICITY TESTING; VISCERA;

ALKALINE PHOSPHATASE; ANIMAL STRUCTURES; ANIMALS; AREA UNDER CURVE; BLOOD CELLS; BLOOD UREA NITROGEN; CHOLESTEROL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FLAVANONES; HALF-LIFE; HEMATOLOGIC TESTS; INJECTIONS, INTRAVENOUS; MODELS, ANIMAL; ORGAN SIZE; PLANT ROOTS; SCUTELLARIA BAICALENSIS; TRIGLYCERIDES;

CANIS FAMILIARIS; SCUTELLARIA BAICALENSIS;

EID: 67449135860     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.04.031     Document Type: Article

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