Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin a by human liver and intestinal microsomes

Pharmaceutical Research

Volumn 27, Issue 8, 2010, Pages 1568-1583

  Zhou, Qiong ^a   Zheng, Zhijie ^a   Xia, Bijun ^a   Tang, Lan ^a   Lv, Chang ^a   Liu, Wei ^a   Liu, Zhongqiu ^a   Hu, Ming ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

flavonoids; intestine; liver; UGT; wogonin

Indexed keywords

FLAVONOID; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; ISOENZYME; OROXYLIN A; WOGONIN; 5,7-DIHYDROXY-6-METHOXY-2-PHENYLCHROMEN-4-ONE; FLAVANONE DERIVATIVE; GLUCOSE TRANSPORTER; GLUCURONIDE; ISOPROTEIN; UDP-GALACTOSE TRANSLOCATOR;

ARTICLE; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTESTINE MICROSOME METABOLISM; LIVER MICROSOME METABOLISM; METABOLIC RATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE METABOLISM; CHEMISTRY; INTESTINE; KINETICS; LIVER MICROSOME; MASS FRAGMENTOGRAPHY; METABOLISM; MICROSOME;

FLAVANONES; FLAVONOIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; INTESTINES; KINETICS; MICROSOMES; MICROSOMES, LIVER; MONOSACCHARIDE TRANSPORT PROTEINS; PROTEIN ISOFORMS;

EID: 77955473210     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0148-0     Document Type: Article

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