Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5- (Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5416-5434

  Kassis, Pamela ^a   Brzeszcz, Joanna ^a,d   Bénéteau, Valérie ^a   Lozach, Olivier ^b   Meijer, Laurent ^b   Le Guével, Rémi ^c   Guillouzo, Christiane ^c   Lewiński, Krzysztof ^d   Bourg, Stéphane ^a   Colliandre, Lionel ^a   Routier, Sylvain ^a   Mérour, Jean Yves ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b STATION BIOLOGIQUE   (France)

^c PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^d JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

CDK; Cytotoxicity; DYRK1A; GSK3; Indole; Molecular modeling; Pyrazine; Pyridine

Indexed keywords

1 BENZENESULFONYL 2 (5 BROMO PYRIDIN 3 YL) 6 METHOXY 1H; 1 BENZENESULFONYL 2 [5 (4 METHANESULFONYL PHENYL) PYRIDIN 3 YL] 6 METHOXY 1H INDOLE; 1 BENZENESULFONYL 2 [6 (4 METHANESULFONYL PHENYL) PYRAZIN 2 YL] 6 METHOXY 1H INDOLE; 1 BENZENESULFONYL 5 BENZYLOXY 2 [5 (4 METHANESULFONYL PHENYL) PYRIDIN 3 YL] 1H INDOLE; 1 BENZENESULFONYL 6 METHOXY 2 [6 (4 METHOXYPHENYL) PYRAZIN 2 YL] 1H INDOLE; 1 BENZENESULFONYL 6 METHOXY 2 TRIBUTYLSTANNYL 1H INDOLE; 1 BENZENSULFONYL 2 (6 CHLORO PYRAZIN 2 YL) 6 METHOXY 1H INDOLE; 1 BENZENSULFONYL 6 METHOXY 2 [5 (4 METHOXY PHENYL) PYRIDIN 3 YL] 1H INDOLE; 2 [4 (4 HYDROXY PHENYL) PYRIDIN 2 YL] 1H INDOL 5 OL; 2 [5 (4 METHANESULFONYL PHENYL) PYRIDIN 3 YL] 1H INDOL 6 OL; 2 [6 (4 HYDROXY PHENYL) PYRAZIN 2 YL] 1H INDOL 6 OL; 2[6 (4 METHANESULFONYL PHENYL) PYRAZIN 2 YL] 6 METHOXY 1H INDOLE; 3 [(2 INDOLYL)] 5 PHENYL 2,4 PYRIDINE; 3 [(2 INDOLYL)] 5 PHENYL 2,6 PYRAZINE; 3 [(2 INDOLYL)] 5 PHENYL 3,5 PYRIDINE; 4 [5 (1 BENZENESULFONYL 5 BENZYLOXY 1H INDOL 2 YL) PYRIDIN 3 YL] BENZONITRILE; 4 [5 (1 BENZENESULFONYL 6 METHOXY 1H INDOL 2 YL) PYRIDIN 3 YL] BENZONITRILE; 4 [5 (6 HYDROXY 1H INDOL 2 YL) PYRIDIN 3 YL] BENZONITRILE; 4 [5 (6 METHOXY 1H INDOL 2 YL) PYRIDIN 3 YL] BENZONITRILE; 4 [6 (1 BENZENESULFONYL 6 METHOXY 1H INDOL 2 YL) PYRAZIN 2 YL] BENZONITRILE; 4 [6 (6 METHOXY 1H INDOL 2 YL) PYRAZIN 2 YL] BENZONITRILE; 6 METHOXY 2 [5 (4 METHOXY PHENYL) PYRIDIN 3 YL] 1H INDOLE; 6 METHOXY 2 [6 (4 METHOXY PHENYL) PYRAZIN 2 YL] 1H INDOLE; CYCLIN DEPENDENT KINASE 5; CYTOTOXIC AGENT; HYDROXYL GROUP; PHOSPHOTRANSFERASE INHIBITOR; PYRAZINE DERIVATIVE; ROSCOVITINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BINDING SITE; CELL SURVIVAL; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MALE; MENTAL DEFICIENCY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; STILLE REACTION; SUZUKI REACTION;

ANTINEOPLASTIC AGENTS; CATALYSIS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; HUMANS; INDOLES; MICROWAVES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PALLADIUM; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRAZINES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054879434     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.048     Document Type: Article

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