Synthesis and biological evaluation of 2-Indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 3, 2002, Pages 465-469

  Li, Qun ^a   Woods, Keith W ^a   Claiborne, Akiyo ^a   Gwaltney, Ii, Stephen L ^a   Barr, Kenneth J ^a   Liu, Gang ^a   Gehrke, Laura ^a   Credo, R Bruce ^a   Hui, Yu Hua ^a   Lee, Jang ^a   Warner, Robert B ^a   Kovar, Peter ^a   Nukkala, Michael A ^a   Zielinski, Nicolette A ^a   Tahir, Stephen K ^a   Fitzgerald, Michael ^a   Kim, Ki H ^a   Marsh, Kennan ^a   Frost, David ^a   Ng, Shi Chung ^a   Rosenberg, Saul ^a   Sham, Hing L ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 105972; A 289099; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; COLCHICINE; COMBRETASTATIN A4; INDOLE DERIVATIVE; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; HUMAN; HUMAN CELL; LUNG CARCINOMA; MICROTUBULE ASSEMBLY; OVARY TUMOR; PHENOTYPE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MICE; MICROTUBULES; MODELS, MOLECULAR; OXAZOLES; POLYMERS; RATS; STEREOISOMERISM; TUBULIN; TUMOR CELLS, CULTURED;

EID: 18244398450     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00759-4     Document Type: Article

References (22)