Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties

European Journal of Medicinal Chemistry

Volumn 40, Issue 12, 2005, Pages 1206-1213

  Dias, Nathalie ^b   Jacquemard, Ulrich ^a   Baldeyrou, Brigitte ^b   Lansiaux, Amélie ^b   Goossens, Jean François ^c   Bailly, Christian ^b,d   Routier, Sylvain ^a   Mérour, Jean Yves ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b INSERM   (France)

^c UNIV LILLE   (France)

^d INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Anticancer agents; Cytotoxicity; DNA binding; Pyrazine derivatives

Indexed keywords

2,6 BIS(4 HYDROXYPHENYL)PYRAZINE; 2,6 BIS[4 (2 AMINOETHOXY)PHENYL]PYRAZINE; 2,6 BIS[4 (2 DIMETHYLAMINOETHOXY)PHENYL]PYRAZINE; 2,6 BIS[4 (2 HYDROXYETHOXY)PHENYL]PYRAZINE; 2,6 BIS[4 (3 DIMETHYLAMINOPROPOXY)PHENYL]PYRAZINE; 2,6 BIS[4 (4,5 DIHYDRO 1H IMIDAZOL 2 YLMETHOXY)PHENYL]PYRAZINE; 2,6 DICHLOROPYRAZINE; 4 METHOXYPHENYLBORONIC ACID; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; HALIDE; HYDROXYL GROUP; PALLADIUM; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CATALYSIS; CATALYST; CONTROLLED STUDY; CYTOTOXICITY; DEPROTECTION REACTION; DRUG ACTIVITY; DRUG DNA BINDING; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PHARMACOGENETICS; SUZUKI REACTION;

ANIMALS; BINDING SITES; CATALYSIS; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYRIBONUCLEASE I; DNA; DNA FOOTPRINTING; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PALLADIUM; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMUS GLAND;

EID: 27744534347     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.07.003     Document Type: Article

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