Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients

Journal of Clinical Investigation

Volumn 105, Issue 9, 2000, Pages 1217-1225

  Lau, Titus ^a   Owen, William ^a   Yu, Yong Ming ^b   Noviski, Natan ^c   Lyons, Jeremy ^d,e   Zurakowski, David ^d   Tsay, Rita ^e   Ajami, Alfred ^f   Young, Vernon R ^e   Castillo, Leticia ^d,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Shriners Burn Hospital   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f MassTrace   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CITRULLINE; NITRIC OXIDE; TRACER;

ADULT; AGED; AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; HUMAN; KIDNEY FAILURE; KINETICS; MALE; OXIDATION; PRIORITY JOURNAL;

EID: 12944250997     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7199     Document Type: Article

References (35)

1. Barbul, A. 1986. Arginine: biochemistry, physiology and therapeutic implications. JPEN J. Parenter. Enteral Nutr. 10:227-238.
2. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051-3056.
3. Schwartz, D, et al. 1997. Agmatine affects glomerular filtration via a nitric oxide synthase-dependent mechanism. Am. J. Physiol. 272:F597-F601.
4. Morgan, D. 1994. Polyamines, arginine and nitric oxide. Biochem. Soc. Trans. 22:879-883.
5. Dhanakoti, S.N., Brosnan, M.E., Herzberg, G.R., and Brosnan, J.T. 1992. Cellular and subcellular localization of enzymes of arginine metabolism in rat kidney. Biochem. J. 282:369-375.
6. Featherston, W.R., Rogers, Q.R., and Freedland, R.A. 1973. Relative importance at kidney and liver in synthesis of arginine by the rat. Am. J. Physiol. 224:127-129.
7. Dhanakoti, S.N., Brosnan, J.T., Herzberg, G.R., and Brosnan, M.E. 1990. Renal arginine synthesis: studies in vitro and in vivo. Am. J. Physiol. 259:E437-E442.
8. Levillain, O., Hus-Citharel, A., Morel, F., and Bankir, L. 1990 Localization of arginine synthesis along rat nephron. Am. J. Physiol. 259:F916-F923.
9. Levillain, O., Hus-Citharel, A., Morel, A., and Bankir, L. 1993. Arginine synthesis in mouse and rabbit nephron: localization and functional significance. Am. J. Physiol. 264:F1038-F1045.
10. Wu, G., and Morris, S.M., Jr. 1998. Arginine metabolism: nitric oxide and beyond. Biochem. J. 336:1-17.
11. Reyes, A.A., Karl, I.E., and Klahr, S. 1994. Role of arginine in health and in renal disease. Am. J. Physiol. 267:F331-F346.
12. Beasley, D., and Brenner, B.M. 1992. Role of nitric oxide in hemodialysis hypotension. Kidney Int. 42:S96-S100.
13. Vallance, P., Leone, A., Calver, A., Collier, J., and Moncada, S. 1992. Accumutation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet. 339:572-575.
14. Wolfson, M., Jones, M.R., and Kopple, J.D. 1982. Amino acid losses during hemodialysis with infusion of amino acids and glucose. Kidney Int. 21:500-506.
15. Blumenkrantz, M.J., et al. 1981. Protein losses during peritoneal dialysis. Kulney Int. 19:593-602.
16. 15N]urea. Am. J. Clin. Nutr. 59:1000-1011.
17. Castillo, L., Bedri, S., Beaumier, L., Ajami, A.M., and Young, V.R. 1997. Adaptation to a long term (4 weeks) arginine precursor-free diet in adult humans. FASEB J. 11:439a. (Abstr.)
18. 15N]citrulline labeling. Proc. Natl. Acad. Sci. USA. 93:11460-11465.
19. Castillo, L., et al. 1994. Plasma arginine kinetics in adult man: response to an arginine-free diet. Metabolism. 43:114-120.
20. Castillo, L., et al. 1993. Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Proc. Natl. Acad. Sci. USA. 90 :7749-7753.
21. Castillo, L., et al. 1993. Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal man. Proc. Natl. Acad. Sci. USA. 90:193-197.
22. Castillo, L., et al. 1994. The plasma flux and oxidation rate of ornithine adaptively decline with restricted arginine intake. Proc. Natl. Acad. Sci. USA. 91:6393-6397.
23. 13C]tyrosine in the postabsorptive state. Metabolism. 31:999-1005.
24. 5]phenylalanine model. Am. J. Physiol. 256 E473-E479.
25. Lim, V.S., Bier, D.M., Flanigan, M.J., and Sum-Ping, S.T. 1993. The effect of hemodialysis on protein metabolism. A leucine kinetic study. J. Clin. Invest. 91:2429-2436.
26. Zar, J.H. 1996. Biostatistical analysis. 3rd edition. Prentice Hall. Upper Saddle River. NJ. 474-480.
27. Littell, R., Freund, R., and Spector, P. 1991. SAS systems for linear models 3rd edition. SAS Institute Inc. Cary. NC. 229-246.
28. Tom, K., et al. 1995. Long-term adaptive responses to dietary protein: restriction in chronic renal failure. Am. J. Physiol. 268:E668-E677.
29. Lim, V.S., Yarasheski, K.E., and Flanigan, M.J. 1998. The effect of uraemia, acidosis, and dialysis treatment on protein metabolism: a longitudinal leucine kinetic study. Nephrol. Dial. Transplant. 13:1723-1730.
30. Tizianello, A., De Ferrari, G., Garibotto, G., Gurrei, G., and Robaudo, C. 1980. Renal metabolism amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J. Clin. Invest. 65:1162-1173.
31. Dhanakoti, S.N., Brosnan, J.T., Brosnan, M.E., and Herzberg, G.R. 1992. Net renal arginine flux in rats is not affected by dietary arginine or dietary protein intake. J. Nutr. 122:1127-1134.
32. Boaby, N., Hassler, C., Parvy, P., and Bankir, I. 1993. Renal synthesis of arginine in chronic renal failure: In vivo and in vitro studies in rats with 5/6 nephrectomy. Kidney Int. 44:676-683.
33. Cobelli, C., and Caumo, A. 1998. Using what is accessible to measure that which is not: necessary of model of system. Metabolism. 47:1009-1035.
34. Yokokawa, K., et al. 1995. Increased nitric oxide production in patients with hypotension during hemodialysis. Ann. Intern. Med. 123:35-37.
35. Wever, R., et al. 1999. Nitric oxide production is reduced in patients with chronic renal failure. Arterioscler. Thromb. Vasc. Biol. 19:1168-1172.