Liver I/R injury is improved by the arginase inhibitor, Nω-hydroxy-nor-L-arginine (nor-NOHA)

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 292, Issue 2, 2007, Pages

  Reid, Kaye M ^a   Tsung, Allan ^a   Kaizu, Takahashi ^a   Jeyabalan, Geetha ^a   Ikeda, Atsushi ^a   Shao, Lifang ^a   Wu, Guoyao ^b   Murase, Noriko ^a   Geller, David A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Arginine; Liver transplantation; Nitric oxide; Preservation injury

Indexed keywords

AMINOTRANSFERASE; ARGININE; CREATININE; ENZYME INHIBITOR; LIVER ENZYME; N OMEGA HYDROXY NOR L ARGININE; UNCLASSIFIED DRUG;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; COLD ISCHEMIA; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME INHIBITION; HISTOPATHOLOGY; LIVER INJURY; LIVER ISCHEMIA; LIVER TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ALANINE TRANSAMINASE; ANIMALS; ARGINASE; ARGININE; ASPARTATE AMINOTRANSFERASES; BIOGENIC POLYAMINES; LIVER; LIVER TRANSPLANTATION; MALE; NITRATES; NITRIC OXIDE; NITRITES; ORNITHINE; PUTRESCINE; RATS; RATS, INBRED LEW; REPERFUSION INJURY; SPERMIDINE; SPERMINE;

EID: 33847077204     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00227.2006     Document Type: Article

References (35)

1. Boucher JL, Custot J, Vadon S, Delaforge M, Lepoivre M, Tenu JP, Yapo A, Mansuy D. Nω-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase. Biochem Biophys Res Commun 203: 1614-1621, 1994.
2. Calabrese F, Valente M, Pettenazzo E, Ferraresso M, Burra P, Cadrobbi R, Cardin R, Bacelle L, Parnigotto A, Rigotti P. The protective effects of L-arginine after liver ischemia-reperfusion injury in a pig model. J Pathol 183: 477-485, 1997.
3. Clavien PA, Rudiger HA, Selzner M. Mechanism of hepatocyte death after ischemia: apoptosis vs. necrosis. Hepatology 33: 1555-1557, 2001.
4. Corraliza IM, Campo ML, Soler G, Modolell M. Determination of arginase activity in macrophages: a micromethod. J Immunol Methods 174: 231-235, 1994.
5. Custot J, Moali C, Brollo M, Boucher JL, Delaforge M, Mansuy D, Tenu JP, Zimmerman JL. The new amino acid Nω-hydroxy-nor-L- arginine: a high-affinity inhibitor of arginase well adapted to bind to its manganes cluster. J Am Chem Soc 119: 4086-4087, 1997.
6. Debonera F, Wang G, Xie J, Que X, Gelman A, Leclair C, Xin D, Shaked A, Olthoff KM. Severe preservation injury induces Il-6/STAT3 activation with lack of cell cycle progression after partial liver graft transplantation. Am J Transplant 4: 1964-1971, 2004.
7. Ferraresso M, Burra P, Cadrobbi R, Calabrese E, Pettenazzo E, Sarzo G, Parnigotto A, Bacelle L, Rigotti P. Protective effect of L-arginine on liver ischemia-reperfusion injury. Transplant Proc 29: 393-394, 1997.
8. Fondevila C, Busuttil RW, and Kupiec-Weglinski JW. Hepatic ischemia/reperfusion injury - a fresh look. Exp Mol Pathol 74: 86-93, 2003.
9. Geller DA, Chia SH, Takahashi Y, Yagnik GP, Tsoulfas G, Murase N. Protective role of the L-arginine-nitric oxide synthase pathway on preservation injury after rat liver transplantation. J Parenter Enteral Nutr 25: 142-147, 2001.
10. Kaizu T, Ikeda A, Nakao A, Takahashi Y, Tsung A, Kohmoto J, Toyokawa H, Shao L, Bucher B, Tomiyama K, Nalesnik MA, Murase N, Geller DA. Donor graft adenoviral iNOS gene transfer ameliorates liver transplant preservation injury and improves survival. Hepatology 43: 464-473, 2006.
11. Kamada N, Calne RY. A surgical experience with five hundred thirty liver transplants in the rat. Surgery 93: 64-69, 1983.
12. Konarska L, Tomaszewski L. A simple quantitative micromethod of arginase assay in blood spots dried on filter paper. Clin Chim Acta 154: 7-18, 1986.
13. Kuo PC, Alfrey EJ, Abe KY, Huie P, Sibley RK, Dafoe DC. Cellular localization and effect of nitric oxide synthesis in a rat model of orthotopic liver transplantation. Transplantation 61: 305-312, 1996.
14. Langle F, Roth E, Steininger R, Winkler S, Muhlbacher F. Arginase release following liver reperfusion. Evidence of hemodynamic action of arginase infusions. Transplantation 59: 1542-1549, 1995.
15. Langle F, Steininger R, Waldmann E, Grunberger T, Benditte H, Mittlbock M, Soliman T, Schindl M, Windberger U, Muhlbacher F, Roth E. Improvement of cardiac output and liver blood flow and reduction of pulmonary vascular resistance by intravenous infusion of L-arginine during the early reperfusion period in pig liver transplantation. Transplantation 63: 1225-1233, 1997.
16. Moali C, Boucher JL, Sari MA, Stuehr DJ, Mansuy D. Substrate specificity of NO synthases: detailed comparison of L-arginine, their Nω-hydroxy derivatives, and Nω-hydroxy-nor-L- arginine. Biochem J 37: 10453-10460, 1998.
17. Mori M, Gotoh T. Regulation of nitric oxide production by arginine metabolic enzymes. Biochem Biophys Res Commun 275: 715-719, 2000.
18. Morris SM Jr, Kepka-Lenhart D, Chen LC. Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells. Am J Physiol Endocrinol Metab 275: E740-E747, 1998.
19. Murphy HS, Warner RL, Bakopoulos N, Dame MK, Varani J, Ward PA. Endothelial cell determinants of susceptibility to neutrophil-mediated killing. Shock 12: 111-117, 1999.
20. Ochoa JB, Bernard AC, Mistry SK, Morris SM, Figert PL, Maley ME, Tsuei BJ, Boulanger BR, Kearney PA. Trauma increases extrahepatic arginase activity. Surgery 12: 419-426, 2000.
21. Olthoff KM. Molecular pathways of regeneration and repair after liver transplantation. World J Surg 26: 831-837, 2002.
22. Pastor CM, Morris SM, Billiar TR. Sources of arginine for induced nitric oxide synthesis in the isolated perfused liver. Am J Physiol Gastrointest Liver Physiol 269: G861-G866, 1995.
23. Pryor WA, Squadrito GL. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol Lung Cell Mol Physiol 268: L699-L722, 1995.
24. Rodriguez JV, Guibert EE, Quintana A, Scandizzi A, Almada L. Role of sodium nitroprusside in the improvement of rat liver preservation in University of Wisconsin solution: a study in the isolated perfused liver model. J Surg Res 87: 201-208, 1999.
25. Roth E, Steininger R, Winkler S, Langle F, Grunberger T, Fugger R, Muhlbacher F. L-Arginine deficiency after liver transplantation as an effect of arginase efflux from the graft. Influence on nitric oxide metabolism. Transplantation 57: 665-669, 1994.
26. Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology 125: 917-936, 2003.
27. Shimamura T, Zhu Y, Zhang S, Jin MB, Ishizaki N, Urakami A, Totsuka E, Lida J, Kishida A, Lee R, Subbotin V, Furukawa H, Starzl TE, Todo S. Protective role of nitric oxide in ischemia and reperfusion injury of the liver. J Am Coll Surg 188: 43-52, 1999.
28. Tenu JP, Lepoivre M, Maoli C, Brollo M, Mansuy D, Boucher J. Effects of the new arginase inhibitor Nω-hydroxyl-nor-L- arginine on NO synthase activity in murine macrophages. Biol Chem 3: 427-438, 1999.
29. Tian Y, Jochum W, Georgiev P, Mortiz W, Graf R, Clavien PA. Kupffer cell-dependent TNF-alpha signaling mediates injury in the arterialized small-for-size liver transplantation in the mouse. Proc Natl Acad Sci USA 103: 4598-4603, 2006.
30. Toledo-Peryera LH. Liver transplantation reperfusion injury. Factors in its development and avenues for treatment. Klin Wochenschr 96: 1009-1014, 1991.
31. Wu G, Flynn NE, Knabe DA. Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets. Am J Physiol Endocrinol Metab 279: E395-E402, 2000.
32. Wu G, Morris SM. Arginine metabolism: nitric oxide and beyond. Biochem J 336: 1-17, 1998.
33. Xian M, Fujiwara N, Wen Z, Cai T, Kazum S, Janczuk AJ, Tang X, Telyatnikov VV, Zhang Y, Chen X, Miyamoto Y, Taniguchi N, Wang PG. Novel substrates for nitric oxide synthases. Bioorg Med Chem 10: 3049-3055, 2002.
34. Yagnik GP, Takahashi Y, Tsoulfas G, Reid K, Murase N, Geller DA. Blockade of the L-arginine/NO synthase pathway worsens hepatic apoptosis and liver transplant preservation injury. Hepatology 36: 573-581, 2002.
35. Yin DP, Sankary HN, Chong AS, Ma LL, Shen J, Foster P, Williams JW. Protective effect of ischemic preconditioning on liver preservation-reperfusion injury in rats. Transplantation 66: 152-157, 1998.