The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization

Clinical Cancer Research

Volumn 17, Issue 20, 2011, Pages 6490-6499

  Sekhar, Konjeti R ^a   Reddy, Yerramreddy Thirupathi ^c   Reddy, Penthala Narsimha ^c   Crooks, Peter A ^c,e   Venkateswaran, Amudhan ^a   McDonald, William Hayes ^b   Geng, Ling ^a   Sasi, Soumya ^a   Van Der Waal, Robert P ^d   Roti Roti, Joseph L ^d   Salleng, Kenneth J ^b   Rachakonda, Girish ^a   Freeman, Michael L ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Kentucky   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [(N BENZYL 1H INDOL 3 YL)METHYLENE]PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; DOUBLE STRANDED DNA; NUCLEOPHOSMIN; RADIOSENSITIZING AGENT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; YTR 107;

ARTICLE; BRAF GENE; COMET ASSAY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; ERBB GENE; FEMALE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIQUID CHROMATOGRAPHY; ONCOGENE; ONCOGENE RAS; PIK3CA GENE; PRIORITY JOURNAL; PROTEOMICS; RADIOSENSITIZATION; TANDEM MASS SPECTROMETRY; TUMOR CELL LINE;

ANIMALS; BARBITURATES; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; HUMANS; INDOLES; MICE; MICE, NUDE; MOLECULAR CHAPERONES; MOLECULAR TARGETED THERAPY; NEOPLASMS; NUCLEAR PROTEINS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RANDOM ALLOCATION;

EID: 80054111106     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-1054     Document Type: Article

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