Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 600-602

  Reddy, Y Thirupathi ^a   Sekhar, Konjeti R ^b   Sasi, Nidhish ^b   Reddy, P Narsimha ^a   Freeman, Michael L ^b   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Aplysinopsin analogs; Indolyl barbiturates; Indolyl hydantoins; Radiosensitizing agents

Indexed keywords

5 [(N BENZYL 1H INDOL 3 YL)METHYLENE]IMIDAZOLIDINE 2,4 DIONE; 5 [(N BENZYL 1H INDOL 3 YL)METHYLENE]PYRIMIDINE 2,4,6(1H,3H,5H)TRIONE; AROMATIC COMPOUND; BENZYL DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; INDOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RADIATION; RADIOSENSITIZATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; BARBITURATES; BENZENE; HT29 CELLS; HUMANS; INDOLES; PYRIMIDINES; RADIATION-SENSITIZING AGENTS;

EID: 72249098975     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.082     Document Type: Article

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