Advancing islet transplantation: From engraftment to the immune response

Diabetologia

Volumn 54, Issue 10, 2011, Pages 2494-2505

  Gibly, R F ^a   Graham, J G ^a   Luo, X ^b   Lowe Jr , W L ^b   Hering, B J ^c,d   Shea, L D ^a,b,e  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e Northwestern University   (United States)

Author keywords

Biomaterial; Biotechnology; Diabetes; Extrahepatic; Immunomodulation; Islet transplantation; Review; Scaffold; Tissue engineering; Tolerance

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TRANSCRIPTION FACTOR FOXP3; VASCULOTROPIN;

ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; AUTOIMMUNITY; BIODEGRADABILITY; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL INFILTRATION; DNA DAMAGE; ENGRAFTMENT; EXTRACELLULAR MATRIX; GRAFT SURVIVAL; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; MICROENVIRONMENT; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY T LYMPHOCYTE; REVASCULARIZATION; REVIEW; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; TREF; UPREGULATION;

BIOTECHNOLOGY; HUMANS; IMMUNOMODULATION; ISLETS OF LANGERHANS TRANSPLANTATION; TISSUE ENGINEERING;

EID: 80054102624     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2243-0     Document Type: Review

References (101)

1. PE Cryer 2008 The barrier of hypoglycemia in diabetes Diabetes 57 3169 3176 19033403 1:CAS:528:DC%2BD1MXhsleisLY%3D
2. G Pambianco T Costacou D Ellis DJ Becker R Klein TJ Orchard 2006 The 30-year natural history of type 1 diabetes complications: the Pittsburgh Epidemiology of Diabetes Complications Study experience Diabetes 55 1463 1469 16644706 1:CAS:528:DC%2BD28XksFahtbY%3D (Pubitemid 44195388)
3. AM Shapiro JR Lakey EA Ryan, et al. 2000 Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen N Engl J Med 343 230 238 10911004 1:CAS:528: DC%2BD3cXlvVSmt7k%3D (Pubitemid 30490390)
4. SS Soedamah-Muthu JH Fuller HE Mulnier VS Raleigh RA Lawrenson HM Colhoun 2006 All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992-1999 Diabetologia 49 660 666 16432708 1:STN:280: DC%2BD287jslSrtw%3D%3D (Pubitemid 43357538)
5. BJ Hering R Kandaswamy JD Ansite, et al. 2005 Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes JAMA 293 830 835 15713772 1:CAS:528:DC%2BD2MXhsVyisrg%3D (Pubitemid 40250366)
6. AM Posselt MD Bellin M Tavakol, et al. 2010 Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab Am J Transplant 10 1870 1880 20659093 1:CAS:528: DC%2BC3cXhtFahsb3M
7. B Hering M Bellin F Barton 2010 Induction immunosuppression with T-cell depleting antibodies facilitates long-term insulin independence after islet allotransplantation in type 1 diabetes Am J Transplant 10 Suppl. 4 141 142 (Abstract)
8. GL Warnock DM Thompson RM Meloche, et al. 2008 A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes Transplantation 86 1762 1766 19104418
9. RN Wang L Rosenberg 1999 Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship J Endocrinol 163 181 190 10556766 1:CAS:528:DyaK1MXns12isbw%3D
10. NR Barshes S Wyllie JA Goss 2005 Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts J Leukoc Biol 77 587 597 15728243 1:CAS:528:DC%2BD2MXktFentL8%3D (Pubitemid 40628740)
11. W Bennet CG Groth R Larsson B Nilsson O Korsgren 2000 Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes Ups J Med Sci 105 125 133 11095109 1:STN:280:DC%2BD3M7js1Gisg%3D%3D
12. AM Shapiro HL Gallant EG Hao, et al. 2005 The portal immunosuppressive storm: relevance to islet transplantation? Ther Drug Monit 27 35 37 15665744 (Pubitemid 40189971)
13. SA Nanji AM Shapiro 2004 Islet transplantation in patients with diabetes mellitus: choice of immunosuppression BioDrugs 18 315 328 15377174 1:CAS:528:DC%2BD2cXpsl2hu7Y%3D (Pubitemid 39381948)
14. J Lau PO Carlsson 2009 Low revascularization of human islets when experimentally transplanted into the liver Transplantation 87 322 325 19202435
15. Y Lee M Ravazzola BH Park YK Bashmakov L Orci RH Unger 2007 Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin Diabetes 56 2295 2301 17563069 1:CAS:528:DC%2BD2sXhtV2gs7fN (Pubitemid 47358236)
16. WF Hiller J Klempnauer R Lück B Steiniger 1991 Progressive deterioration of endocrine function after intraportal but not kidney subcapsular rat islet transplantation Diabetes 40 134 140 2015968 1:STN:280: DyaK3M3gtVCiug%3D%3D
17. DM Salvay CB Rives X Zhang, et al. 2008 Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation Transplantation 85 1456 1464 18497687 1:CAS:528: DC%2BD1cXmvFent70%3D
18. GG Pinkse WP Bouwman R Jiawan-Lalai OT Terpstra JA Bruijn E de Heer 2006 Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans Diabetes 55 312 317 16443762 1:CAS:528:DC%2BD28XhsFajsr0%3D (Pubitemid 43343258)
19. S Bonner-Weir WC Li L Ouziel-Yahalom L Guo GC Weir A Sharma 2010 Beta-cell growth and regeneration: replication is only part of the story Diabetes 59 2340 2348 20876724 1:CAS:528:DC%2BC3cXhsVGhs7vE
20. T Kheradmand S Wang RF Gibly, et al. 2011 Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions Biomaterials 32 4517 4524 21458857 1:CAS:528:DC%2BC3MXlslSrtbg%3D
21. C Aguayo-Mazzucato S Bonner-Weir 2010 Stem cell therapy for type 1 diabetes mellitus Nat Rev Endocrinol 6 139 148 20173775
22. H Blomeier X Zhang C Rives, et al. 2006 Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation Transplantation 82 452 459 16926587 1:CAS:528:DC%2BD28XotlOitb4%3D (Pubitemid 44290249)
23. DM Berman JJ O'Neil LC Coffey, et al. 2009 Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold Am J Transplant 9 91 104 19133931 1:STN:280:DC%2BD1M%2FmtlOjtw%3D%3D
24. S Merani C Toso J Emamaullee AM Shapiro 2008 Optimal implantation site for pancreatic islet transplantation Br J Surg 95 1449 1461 18991254 1:STN:280:DC%2BD1cjktlSksw%3D%3D
25. JL Contreras 2008 Extrahepatic transplant sites for islet xenotransplantation Xenotransplantation 15 99 101 18447878 (Pubitemid 351601128)
26. WJ Tze J Tai 1989 Immunological studies in diabetic rat recipients with a pancreatic islet cell allograft in the brain Transplantation 47 1053 1057 2499961 1:STN:280:DyaL1M3osVWltQ%3D%3D
27. KB Whittington SS Solomon ZN Lu HP Selawry 1991 Islet allografts in the cryptorchid testes of spontaneously diabetic BB/Wor dp rats: response to glucose, glipizide, and arginine Endocrinology 128 2671 2677 1674684 1:CAS:528:DyaK3MXksVOisbk%3D
28. GJ Echeverri K McGrath R Bottino, et al. 2009 Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs Am J Transplant 9 2485 2496 19775318 1:STN:280: DC%2BD1Mjgtl2guw%3D%3D
29. VL Perez A Caicedo DM Berman, et al. 2011 The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes Diabetologia 54 1121 1126 21360190 1:STN:280: DC%2BC3Mvhtl2jsA%3D%3D
30. M Perez-Basterrechea RM Briones M Alvarez-Viejo, et al. 2009 Plasma-fibroblast gel as scaffold for islet transplantation Tissue Eng Part A 15 569 577 18694292 1:CAS:528:DC%2BD1MXivVGhtbs%3D
31. JY Lim BH Min BG Kim, et al. 2009 A fibrin gel carrier system for islet transplantation into kidney subcapsule Acta Diabetol 46 243 248 19030773 1:CAS:528:DC%2BD1MXptVGmsrs%3D
32. AM Hiscox AL Stone S Limesand JB Hoying SK Williams 2007 An islet-stabilizing implant constructed using a preformed vasculature Tissue Eng Part A 14 433 440
33. J Beck R Angus B Madsen D Britt B Vernon KT Nguyen 2007 Islet encapsulation: strategies to enhance islet cell functions Tissue Eng 13 589 599 17518605 1:CAS:528:DC%2BD2sXivVSltLs%3D (Pubitemid 46579884)
34. A Murua A Portero G Orive RM Hernández M de Castro JL Pedraz 2008 Cell microencapsulation technology: towards clinical application J Control Release 132 76 83 18789985 1:CAS:528:DC%2BD1cXhsVSqtLjE
35. Y Lai D Schneider A Kidszun, et al. 2005 Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets Transplantation 79 1530 1536 15940042 1:CAS:528:DC%2BD2MXksl2gtr8%3D (Pubitemid 40847584)
36. R Olsson A Maxhuni P-O Carlsson 2006 Revascularization of transplanted pancreatic islets following culture with stimulators of angiogenesis Transplantation 82 340 347 16906031 1:CAS:528:DC%2BD28XotVWksbc%3D (Pubitemid 44223032)
37. W Wang Y Gu Y Tabata, et al. 2002 Reversal of diabetes in mice by xenotransplantation of a bioartificial pancreas in a prevascularized subcutaneous site Transplantation 73 122 129 11792991 (Pubitemid 34094698)
38. AN Balamurugan Y Gu Y Tabata, et al. 2003 Bioartificial pancreas transplantation at prevascularized intermuscular space: effect of angiogenesis induction on islet survival Pancreas 26 279 285 12657955 1:CAS:528: DC%2BD3sXmvFSntLk%3D (Pubitemid 36384161)
39. HJ Song WJ Xue Y Li, et al. 2010 Prolongation of islet graft survival using concomitant transplantation of islets and vascular endothelial cells in diabetic rats Transplant Proc 42 2662 2665 20832565
40. FT Thomas JL Contreras G Bilbao C Ricordi D Curiel JM Thomas 1999 Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation Surgery 126 299 304 10455898 1:STN:280:DyaK1MzosVynsg%3D%3D (Pubitemid 29382795)
41. 1 J Biol Chem 279 53762 53769 15485856 1:CAS:528:DC%2BD2cXhtVKqu7rP (Pubitemid 40051885)
42. KA Ghofaili M Fung Z Ao, et al. 2007 Effect of exenatide on beta cell function after islet transplantation in type 1 diabetes Transplantation 83 24 28 17220786 (Pubitemid 46104966)
43. N Giannoukakis Z Mi WA Rudert A Gambotto M Trucco P Robbins 2000 Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I Gene Ther 7 2015 2022 11175313 1:CAS:528:DC%2BD3cXoslWltbc%3D (Pubitemid 32036767)
44. M Johansson J Olerud L Jansson PO Carlsson 2009 Prolactin treatment improves engraftment and function of transplanted pancreatic islets Endocrinology 150 1646 1653 19095742 1:CAS:528:DC%2BD1MXktVWmu7g%3D
45. JD Rivas-Carrillo A Soto-Gutierrez N Navarro-Alvarez, et al. 2007 Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice Diabetes 56 1259 1267 17287463 1:CAS:528:DC%2BD2sXltlantbs%3D (Pubitemid 46715606)
46. A Gangemi P Salehi B Hatipoglu, et al. 2008 Islet transplantation for brittle type 1 diabetes: the UIC protocol Am J Transplant 8 1250 1261 18444920 1:CAS:528:DC%2BD1cXnvFyhsrY%3D (Pubitemid 351763686)
47. EJ Pollauf KK Kim DW Pack 2005 Small-molecule release from poly(d,l-lactide)/poly(d,l-lactide-co-glycolide) composite microparticles J Pharm Sci 94 2013 2022 16052542 1:CAS:528:DC%2BD2MXpslOgtLo%3D (Pubitemid 41551484)
48. RR Chen EA Silva WW Yuen DJ Mooney 2007 Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation Pharm Res 24 258 264 17191092 (Pubitemid 46072185)
49. CB Rives A des Rieux M Zelivyanskaya SR Stock WL Lowe Jr LD Shea 2009 Layered PLG scaffolds for in vivo plasmid delivery Biomaterials 30 394 401 18929408 1:CAS:528:DC%2BD1cXhtlCkt7bJ
50. AL Mellor DH Munn 2008 Creating immune privilege: active local suppression that benefits friends, but protects foes Nat Rev Immunol 8 74 80 18064049 1:CAS:528:DC%2BD2sXhsVKrsLnM
51. KJ Wood S Sakaguchi 2003 Regulatory T cells in transplantation tolerance Nat Rev Immunol 3 199 210 12658268 1:CAS:528:DC%2BD3sXitleqtL8%3D (Pubitemid 37323205)
52. JK Olson JL Croxford SD Miller 2001 Virus-induced autoimmunity: potential role of viruses in initiation, perpetuation, and progression of T cell-mediated autoimmune disease Viral Immunol 14 227 250 11572634 1:CAS:528: DC%2BD3MXmvV2nuro%3D (Pubitemid 32852058)
53. JM Dufour SJ Lord T Kin, et al. 2008 Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice Cell Transplant 16 1029 1038 18351019 (Pubitemid 351732845)
54. LM van Duivenvoorde GJ van Mierlo ZF Boonman RE Toes 2006 Dendritic cells: vehicles for tolerance induction and prevention of autoimmune diseases Immunobiology 211 627 632 16920501
55. J Banchereau F Briere C Caux, et al. 2000 Immunobiology of dendritic cells Annu Rev Immunol 18 767 811 10837075 1:CAS:528:DC%2BD3cXjs1GmtrY%3D (Pubitemid 30365397)
56. -) prolong cardiac allograft survival in nonimmunosuppressed recipients Transplantation 62 659 665 8830833 1:CAS:528:DyaK28Xmtlyksrw%3D (Pubitemid 26313912)
57. T Ito M Yang YH Wang, et al. 2007 Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand J Exp Med 204 105 115 17200410 1:CAS:528:DC%2BD2sXhtFGjtro%3D (Pubitemid 46148761)
58. M Colonna G Trinchieri YJ Liu 2004 Plasmacytoid dendritic cells in immunity Nat Immunol 5 1219 1226 15549123 1:CAS:528:DC%2BD2cXpvV2rsbg%3D (Pubitemid 41057736)
59. M Garrovillo A Ali SF Oluwole 1999 Indirect allorecognition in acquired thymic tolerance: induction of donor-specific tolerance to rat cardiac allografts by allopeptide-pulsed host dendritic cells Transplantation 68 1827 1834 10628758 1:STN:280:DC%2BD3c%2Fpt1eguw%3D%3D (Pubitemid 30027331)
60. K Sato N Yamashita M Baba T Matsuyama 2003 Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells Blood 101 3581 3589 12511411 1:CAS:528:DC%2BD3sXjs1aqtrw%3D (Pubitemid 36857945)
61. K Sato N Yamashita M Baba T Matsuyama 2003 Regulatory dendritic cells protect mice from murine acute graft-vs-host disease and leukemia relapse Immunity 18 367 379 12648454 1:CAS:528:DC%2BD3sXisFKhu7c%3D (Pubitemid 36351516)
62. + regulatory T cells Trends Immunol 25 374 380 15207505 1:CAS:528:DC%2BD2cXltVKjtb8%3D (Pubitemid 38780954)
63. + T regulatory cell-mediated suppression Immunity 30 636 645 19464986 1:CAS:528: DC%2BD1MXosVCks7g%3D
64. Y Belkaid 2007 Regulatory T cells and infection: a dangerous necessity Nat Rev Immunol 7 875 888 17948021 1:CAS:528:DC%2BD2sXht1WgsL7I (Pubitemid 350006238)
65. + regulatory T cells is mediated by cell surface-bound transforming growth factor beta J Exp Med 194 629 644 11535631 1:CAS:528:DC%2BD3MXms1KhsLo%3D (Pubitemid 32844773)
66. N Zhang B Schroppel G Lal, et al. 2009 Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response Immunity 30 458 469 19303390 1:CAS:528:DC%2BD1MXltFSmt7c%3D
67. + T cells in vitro with TGF-β1 for islet transplantation Am J Transplant 10 1774 1784 20626386 1:CAS:528:DC%2BC3cXhtFahsbzI
68. X Luo KL Pothoven D McCarthy, et al. 2008 ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms Proc Natl Acad Sci USA 105 14527 14532 18796615 1:CAS:528:DC%2BD1cXht1Sgt77N
69. + regulatory T cells Proc Natl Acad Sci USA 104 2821 2826 17307871 1:CAS:528:DC%2BD2sXisVSnsLY%3D (Pubitemid 46327963)
70. + T cell subsets expressing a regulatory/suppressive phenotype Haematologica 90 516 525 15820948 1:CAS:528:DC%2BD2MXksFGms7g%3D (Pubitemid 40592895)
71. M Di Nicola C Carlo-Stella M Magni, et al. 2002 Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli Blood 99 3838 3843 11986244 (Pubitemid 34534559)
72. DM Berman MA Willman D Han, et al. 2010 Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates Diabetes 59 2558 2568 20622174 1:CAS:528:DC%2BC3cXhsVGhs7bJ
73. DO Adams 1989 Molecular interactions in macrophage activation Immunol Today 10 33 35 2665771 1:STN:280:DyaL1Mzit1Kmtw%3D%3D
74. JA Corbett MA Sweetland JL Wang JR Lancaster Jr ML McDaniel 1993 Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans Proc Natl Acad Sci USA 90 1731 1735 8383325 1:CAS:528: DyaK3sXhs1Ogs7w%3D (Pubitemid 23069930)
75. S Nagata T Suda 1995 Fas and Fas ligand: lpr and gld mutations Immunol Today 16 39 43 7533498 1:CAS:528:DyaK2MXjsVyjtrc%3D
76. M Arnush AL Scarim MR Heitmeier CB Kelly JA Corbett 1998 Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes J Immunol 160 2684 2691 9510167 1:CAS:528:DyaK1cXhvVWhtLc%3D (Pubitemid 28136719)
77. JL Contreras C Eckstein CA Smyth, et al. 2004 Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death Diabetes 53 2804 2814 15504960 1:CAS:528:DC%2BD2cXpvV2it7o%3D (Pubitemid 39425905)
78. S Akima WJ Hawthorne E Favaloro, et al. 2009 Tirofiban and activated protein C synergistically inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from allogeneic islet cells exposure to human blood Am J Transplant 9 1533 1540 19459790 1:CAS:528:DC%2BD1MXhtVSqtbjP
79. W Cui JT Wilson J Wen, et al. 2009 Thrombomodulin improves early outcomes after intraportal islet transplantation Am J Transplant 9 1308 1316 19459803 1:CAS:528:DC%2BD1MXosVaru7s%3D
80. S Gordon 2003 Alternative activation of macrophages Nat Rev Immunol 3 23 35 12511873 1:CAS:528:DC%2BD3sXovVw%3D (Pubitemid 37328697)
81. MA Cassatella L Meda S Bonora M Ceska G Constantin 1993 Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharide J Exp Med 178 2207 2211 8245792 1:CAS:528:DyaK3sXmt1equrs%3D (Pubitemid 23344879)
82. L Sun RF Guo MW Newstead TJ Standiford DR Macariola TP Shanley 2009 Effect of IL-10 on neutrophil recruitment and survival after Pseudomonas aeruginosa challenge Am J Respir Cell Mol Biol 41 76 84 19097982 1:CAS:528:DC%2BD1MXnvF2murc%3D
83. MO Aviles CH Lin M Zelivyanskaya, et al. 2010 The contribution of plasmid design and release to in vivo gene expression following delivery from cationic polymer modified scaffolds Biomaterials 31 1140 1147 19892398 1:CAS:528:DC%2BD1MXhs1SltL7E
84. OA Ali N Huebsch L Cao G Dranoff DJ Mooney 2009 Infection-mimicking materials to program dendritic cells in situ Nat Mater 8 151 158 19136947 1:CAS:528:DC%2BD1MXps1ejsw%3D%3D
85. JL Viney AM Mowat JM O'Malley E Williamson NA Fanger 1998 Expanding dendritic cells in vivo enhances the induction of oral tolerance J Immunol 160 5815 5825 9637492 1:CAS:528:DyaK1cXjvVWrsLo%3D (Pubitemid 28298039)
86. JD Shields IC Kourtis AA Tomei JM Roberts MA Swartz 2010 Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21 Science 328 749 752 20339029 1:CAS:528:DC%2BC3cXlsFCitb4%3D
87. M Battaglia A Stabilini E Draghici, et al. 2006 Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance Diabetes 55 40 49 16380475 1:CAS:528:DC%2BD28XlvVSmtw%3D%3D (Pubitemid 43343297)
88. F Kimura M Gotoh T Tanaka, et al. 2002 Locally expressed CTLA4-Ig in a pancreatic beta-cell line suppresses accelerated graft rejection response induced by donor-specific transfusion Diabetologia 45 831 840 12107727 1:CAS:528:DC%2BD38XkslSgu78%3D
89. N Papeta T Chen F Vianello, et al. 2007 Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent Transplantation 83 174 183 17264814 1:CAS:528:DC%2BD2sXhtVyisr4%3D (Pubitemid 46185208)
90. ST Reddy AJ van der Vlies E Simeoni, et al. 2007 Exploiting lymphatic transport and complement activation in nanoparticle vaccines Nat Biotechnol 25 1159 1164 17873867 1:CAS:528:DC%2BD2sXhtFagt7rK (Pubitemid 47538111)
91. XX Zheng TG Markees WW Hancock, et al. 1999 CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment J Immunol 162 4983 4990 10202046 1:CAS:528:DyaK1MXisFOrtro%3D (Pubitemid 29314906)
92. TC Pearson JC Madsen CP Larsen PJ Morris KJ Wood 1992 Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody Transplantation 54 475 483 1384183 1:STN:280:DyaK3s%2Fjt1Wltg%3D%3D
93. JD Punch T Tono L Qin DK Bishop JS Bromberg 1998 Tolerance induction by anti-CD2 plus anti-CD3 monoclonal antibodies: evidence for an IL-4 requirement J Immunol 161 1156 1162 9686574 1:CAS:528:DyaK1cXltVeiurw%3D (Pubitemid 28380540)
94. L Xu M Villain FS Galin S Araga JE Blalock 2001 Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T cells Cell Immunol 208 107 114 11333143 1:CAS:528:DC%2BD3MXjtFeitLg%3D
95. H Braley-Mullen JG Tompson GC Sharp M Kyriakos 1980 Suppression of experimental autoimmune thyroiditis in guinea pigs by pretreatment with thyroglobulin-coupled spleen cells Cell Immunol 51 408 413 6154539 1:STN:280:DyaL3c7nslWgsA%3D%3D (Pubitemid 10153399)
96. HS Dua DS Gregerson LA Donoso 1992 Inhibition of experimental autoimmune uveitis by retinal photoreceptor antigens coupled to spleen cells Cell Immunol 139 292 305 1733504 1:STN:280:DyaK387islGqug%3D%3D
97. AA Vandenbark M Vainiene K Ariail SD Miller H Offner 1996 Prevention and treatment of relapsing autoimmune encephalomyelitis with myelin peptide-coupled splenocytes J Neurosci Res 45 430 438 8872903 1:CAS:528:DyaK28XlsVOksL8%3D (Pubitemid 26299598)
98. SD Miller DM Turley JR Podojil 2007 Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease Nat Rev Immunol 7 665 677 17690713 1:CAS:528:DC%2BD2sXpsV2qtb4%3D (Pubitemid 47327394)
99. R Nano B Clissi R Melzi, et al. 2005 Islet isolation for allotransplantation: variables associated with successful islet yield and graft function Diabetologia 48 906 912 15830183 1:STN:280:DC%2BD2M3ltFarsQ%3D%3D (Pubitemid 40767984)
100. H Noguchi 2010 Production of pancreatic beta-cells from stem cells Curr Diabetes Rev 6 184 190 20380628 1:CAS:528:DC%2BC3cXms1agu7Y%3D
101. BJ Hering N Walawalkar 2009 Pig-to-nonhuman primate islet xenotransplantation Transpl Immunol 21 81 86 19427901