Indirect allorecognition in acquired thymic tolerance: Induction of donor-specific tolerance to rat cardiac allografts by allopeptide-pulsed host dendritic cells

Transplantation

Volumn 68, Issue 12, 1999, Pages 1827-1834

  Garrovillo, Mel ^a   Ali, Ayoola ^a   Oluwole, Soji F ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; LYMPHOCYTE ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; BONE MARROW CELL; CONFERENCE PAPER; CONTROLLED STUDY; DENDRITIC CELL; DONOR; GENETIC ENGINEERING; GRAFT SURVIVAL; HEART TRANSPLANTATION; HOST CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; MIXED LYMPHOCYTE REACTION; NONHUMAN; PRIORITY JOURNAL; RAT; THYMUS;

EID: 0033611075     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199912270-00001     Document Type: Conference Paper

References (30)

1. Ashton-Rickardt PG, Van Kaer L, Schumacher TNM, Ploegh HL, Tonegawa S. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell 1993; 73: 1041.
2. + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J Exp Med 1993; 177: 1469.
3. Walunas TL, Sperling AL, Khattri R, Thompson CB, Bluestone JA. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J Immunol 1996; 156: 1006.
4. Brocker T, Riedinger M, Karjalainen K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce - but not + selection of thymocytes in vivo. J Exp Med 1997; 185: 541.
5. Sayegh M, Perico N, Imberti O, Hancock W, Carpenter C, Remuzzi G. Thymic recognition of class II MHC allopeptides induces donor-specific unresponsiveness to renal allografts. Transplantation 1993; 56: 461.
6. Chowdhury NC, Murphy B, Sayegh MH, et al.. Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides. Transplantation 1996; 62: 1878.
7. Mhoyan A, Cramer DV, Baquerizo A, Shirwan H. Induction of allograft non-responsiveness after intrathymic inoculation with donor class I allopeptides. I. Correlation of graft survival with antidonor IgG antibody subclasses. Transplantation 1997; 64: 1665.
8. u)-derived class I peptide. Transplantation 1998; 66: 1059.
9. Oluwole SF, Chowdhury NC, Ingram M, Garrovillo M, Jin MX, Agrawal S. Mechanism of acquired thymic tolerance induced by a single MHC-class I peptide with the dominant epitope: differential 'analysis of regulatory cytokines in the lymphoid and intragraft compartments. Transplantation 1999; 68: 418.
10. Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9: 271.
11. Chen-Woan M, Delaney CP, Fournier V, et al. 1996. A new protocol for the propagation of dendritic cells from rat bone marrow using recombinant GM-CSF and their quantification using mAb OX-62. J Immunol Methods 1995; 178: 157.
12. Oluwole SF, Engelstad K, James T. Prevention of graft-versus-host disease and bone marrow rejection: kinetics of induction of tolerance by UVB modulation of accessory cells in the bone marrow inoculum. Blood 1993; 81: 1658.
13. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225.
14. Oluwole SF, Chowdhury NC, Fawwaz RA. Induction of donor specific unresponsiveness to rat cardiac allografts by pretreatment with donor major histocompatibility complex class I antigen. Transplantation 1993; 55: 1396.
15. Oluwole SF, Jin MX, Chowdhury NC, Ohajekwe OA. Effectiveness of intrathymic inoculation of soluble antigens in the induction of specific unresponsiveness to rat islet allograft without transient recipient immunosuppression. Transplantation 1994; 58: 1077.
16. Wrenshall L, Suciu-Foca N, Cortesini R, et al. Antigen presentation. Graft 1999; 2: 12.
17. Benichou G, Fedoseyeva EV. The contribution of peptides to T cell allorecogntion and allograft rejection. Int Rev Immunol 1996; 13: 231.
18. Liu Z, Colovai AI, Tugulea S, et al. Indirect recognition of donor HLA-DR peptides in organ allograft rejection. J Clin Invest 1996; 98: 1150.
19. Gallon L, Watschinger B, Murphy B, Akalin E, Sayegh MH, Carpenter CB. The indirect pathway of allorecognition: the occurrence of self-restricted T cell recognition of allo-MHC peptides early in acute renal allograft rejection and its inhibition by conventional immunosuppression. Transplantation 1995; 59: 612.
20. Vella JP, Spadafora-Ferreira M, Murphy B, et al. Indirect allorecognition of major histocompatibilitly complex allopeptides in human renal transplant recipients with chronic graft dysfunction. Transplantation 1997; 64: 795.
21. Salllusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin-4 and down-regulation by tumor necrosis factor. J Exp Med 1994; 179: 1109.
22. Banuls MP, Alvarez A, Ferrero I, Zapata A, Ardavin C. Cell-surface marker analysis of rat thymic dendritic cells. Immunology 1993; 79; 298.
23. Liu Z, Braunstein NS, Suciu-Foca N. T cell recognition of allopeptides in the context of syngeneic MHC. J Immunol 1992; 148: 35.
24. Watschinger B, Gallon L, Carpenter CB, Sayegh MH. Mechanisms of allo-recognition: recognition by in vivo primed T cells of specific major histocompatibility complex polymorphisms presented on peptides by responder antigen-presenting cells. Transplantation 1994; 57: 572.
25. Jenkinson EJ, Jhittay P, Kingston R, Owen JJT. Studies of the role of the thymic environment in the induction of tolerance to MHC antigens. Transplantation 1985; 39: 331.
26. Burnet FM. Role of the thymus and related organs in immunity. Br Med J 1962; 2: 807.
27. Matzinger P, Guerder S. Does T-cell tolerance require a dedicated antigen-presenting cell? Nature 1989; 338: 74.
28. Chen W, Issazadeh S, Sayegh MH, Khoury SJ. In vivo mechanisms of acquired thymic tolerance. Cell Immunol 1997; 179: 165.
29. Chen W, Sayegh MH, Khoury SJ. Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy. J Immunol 1998; 160: 1504.
30. Saborio DV, Chowdhury NC, Jin MX, Chandraker A, Sayegh MH, Oluwole SF. Regulatory T cells maintain tolerance to islet allografts induced by intrathymic injection of MHC class I allopeptides. Cell Transplant 1999; 8: 375.