Structural Basis for the Dual Recognition of IL-12 and IL-23 by Ustekinumab

Journal of Molecular Biology

Volumn 402, Issue 5, 2010, Pages 797-812

  Luo, Jinquan ^a   Wu, Sheng Jiun ^a   Lacy, Eilyn R ^a   Orlovsky, Yevgeniya ^a   Baker, Audrey ^a   Teplyakov, Alexey ^a   Obmolova, Galina ^a   Heavner, George A ^a   Richter, Hans Thomas ^b   Benson, Jacqueline ^a  

^a CENTOCOR INC   (United States)

^b Emerald Biosystems   (United States)

Author keywords

Autoimmune disease; Cytokine antibody complex structure; IL 12 IL 23; Psoriasis; Ustekinumab

Indexed keywords

EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 23; INTERLEUKIN 23P40; UNCLASSIFIED DRUG; USTEKINUMAB; IMMUNOLOGIC FACTOR; MONOCLONAL ANTIBODY; PROTEIN BINDING;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG PROTEIN BINDING; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; AMINO ACID SUBSTITUTION; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN QUATERNARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-12; INTERLEUKIN-23; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY;

EID: 77957227339     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.07.046     Document Type: Article

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