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Volumn 4, Issue 193, 2011, Pages

Itk controls the spatiotemporal organization of T cell activation

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERLEUKIN 2; INTERLEUKIN 2 INDUCIBLE T LYMPHOCYTE KINASE; PROTEIN CDC42; PROTEIN TYROSINE KINASE; SWITCH ASSOCIATED PROTEIN 70 LIKE ADAPTOR OF T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR DELTA CHAIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; EMT PROTEIN TYROSINE KINASE; EMT PROTEIN-TYROSINE KINASE; NUCLEAR PROTEIN; SLAT PROTEIN, MOUSE;

EID: 80053484003     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001821     Document Type: Article
Times cited : (45)

References (46)
  • 2
    • 0031012266 scopus 로고    scopus 로고
    • Selective modulation of protein kinase C-θ during T-cell activation
    • C. R. Monks, H. Kupfer, I. Tamir, A. Barlow, A. Kupfer, Selective modulation of protein kinase C-θ during T-cell activation. Nature 385, 83-86 (1997).
    • (1997) Nature , vol.385 , pp. 83-86
    • Monks, C.R.1    Kupfer, H.2    Tamir, I.3    Barlow, A.4    Kupfer, A.5
  • 4
    • 14544307446 scopus 로고    scopus 로고
    • T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells
    • B. Purtic, L. A. Pitcher, N. S. Van Oers, C. Wülfing, T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells. Proc. Natl. Acad. Sci. U.S.A. 102, 2904-2909 (2005).
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 2904-2909
    • Purtic, B.1    Pitcher, L.A.2    Van Oers, N.S.3    Wülfing, C.4
  • 9
    • 0037154747 scopus 로고    scopus 로고
    • T cell receptor signaling precedes immunological synapse formation
    • K. H. Lee, A. D. Holdorf, M. L. Dustin, A. C. Chan, P. M. Allen, A. S. Shaw, T cell receptor signaling precedes immunological synapse formation. Science 295, 1539-1542 (2002).
    • (2002) Science , vol.295 , pp. 1539-1542
    • Lee, K.H.1    Holdorf, A.D.2    Dustin, M.L.3    Chan, A.C.4    Allen, P.M.5    Shaw, A.S.6
  • 10
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • J. C. Stinchcombe, G. Bossi, S. Booth, G. M. Griffiths, The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 15, 751-761 (2001).
    • (2001) Immunity , vol.15 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3    Griffiths, G.M.4
  • 15
    • 0032543221 scopus 로고    scopus 로고
    • T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
    • K. Q. Liu, S. C. Bunnell, C. B. Gurniak, L. J. Berg, T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J. Exp. Med. 187, 1721-1727 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 1721-1727
    • Liu, K.Q.1    Bunnell, S.C.2    Gurniak, C.B.3    Berg, L.J.4
  • 17
    • 34249854024 scopus 로고    scopus 로고
    • SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK
    • Y. Bogin, C. Ainey, D. Beach, D. Yablonski, SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. Proc. Natl. Acad. Sci. U.S.A. 104, 6638-6643 (2007).
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 6638-6643
    • Bogin, Y.1    Ainey, C.2    Beach, D.3    Yablonski, D.4
  • 19
    • 0037446773 scopus 로고    scopus 로고
    • Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor
    • J. A. Grasis, C. D. Browne, C. D. Tsoukas, Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor. J. Immunol. 170, 3971-3976 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3971-3976
    • Grasis, J.A.1    Browne, C.D.2    Tsoukas, C.D.3
  • 21
    • 73349137004 scopus 로고    scopus 로고
    • Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cγ1 Microcluster dynamics during T cell spreading
    • E. Carrizosa, T. S. Gomez, C. M. Labno, D. A. Klos Dehring, X. Liu, B. D. Freedman, D. D. Billadeau, J. K. Burkhardt, Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cγ1 Microcluster dynamics during T cell spreading. J. Immunol. 183, 7352-7361 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 7352-7361
    • Carrizosa, E.1    Gomez, T.S.2    Labno, C.M.3    Klos Dehring, D.A.4    Liu, X.5    Freedman, B.D.6    Billadeau, D.D.7    Burkhardt, J.K.8
  • 22
    • 33746215226 scopus 로고    scopus 로고
    • Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization
    • I. Tskvitaria-Fuller, A. Seth, N. Mistry, H. Gu, M. K. Rosen, C. Wülfing, Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization. J. Immunol. 177, 1708-1720 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 1708-1720
    • Tskvitaria-Fuller, I.1    Seth, A.2    Mistry, N.3    Gu, H.4    Rosen, M.K.5    Wülfing, C.6
  • 24
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • S. J. Szabo, A. S. Dighe, U. Gubler, K. M. Murphy, Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817-824 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 25
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • C. R. Monks, B. A. Freiberg, H. Kupfer, N. Sciaky, A. Kupfer, Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82-86 (1998).
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 27
    • 33846200371 scopus 로고    scopus 로고
    • Protein transduction as a means of effective manipulation of Cdc42 activity in primary T cells
    • I. Tskvitaria-Fuller, N. Mistry, S. Sun, C. Wülfing, Protein transduction as a means of effective manipulation of Cdc42 activity in primary T cells. J. Immunol. Methods 319, 64-78 (2007).
    • (2007) J. Immunol. Methods , vol.319 , pp. 64-78
    • Tskvitaria-Fuller, I.1    Mistry, N.2    Sun, S.3    Wülfing, C.4
  • 28
    • 55349108147 scopus 로고    scopus 로고
    • Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation
    • S. Bécart, A. J. Balancio, C. Charvet, S. Feau, C. E. Sedwick, A. Altman, Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation. Immunity 29, 704-719 (2008).
    • (2008) Immunity , vol.29 , pp. 704-719
    • Bécart, S.1    Balancio, A.J.2    Charvet, C.3    Feau, S.4    Sedwick, C.E.5    Altman, A.6
  • 29
    • 0035905308 scopus 로고    scopus 로고
    • The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis
    • M. K. McGavin, K. Badour, L. A. Hardy, T. J. Kubiseski, J. Zhang, K. A. Siminovitch, The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis. J. Exp. Med. 194, 1777-1787 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1777-1787
    • McGavin, M.K.1    Badour, K.2    Hardy, L.A.3    Kubiseski, T.J.4    Zhang, J.5    Siminovitch, K.A.6
  • 30
  • 31
    • 18844449626 scopus 로고    scopus 로고
    • Vav-family proteins in T-cell signalling
    • V. L. Tybulewicz, Vav-family proteins in T-cell signalling. Curr. Opin. Immunol. 17, 267-274 (2005).
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 267-274
    • Tybulewicz, V.L.1
  • 32
    • 24944560377 scopus 로고    scopus 로고
    • A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
    • F. Stegmeier, G. Hu, R. J. Rickles, G. J. Hannon, S. J. Elledge, A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 102, 13212-13217 (2005).
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 13212-13217
    • Stegmeier, F.1    Hu, G.2    Rickles, R.J.3    Hannon, G.J.4    Elledge, S.J.5
  • 33
    • 51349131307 scopus 로고    scopus 로고
    • The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality
    • S. Cemerski, J. Das, E. Giurisato, M. A. Markiewicz, P. M. Allen, A. K. Chakraborty, A. S. Shaw, The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity 29, 414-422 (2008).
    • (2008) Immunity , vol.29 , pp. 414-422
    • Cemerski, S.1    Das, J.2    Giurisato, E.3    Markiewicz, M.A.4    Allen, P.M.5    Chakraborty, A.K.6    Shaw, A.S.7
  • 34
    • 77955382096 scopus 로고    scopus 로고
    • Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42
    • P. Sinai, C. Nguyen, J. D. Schatzle, C. Wülfing, Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42. Proc. Natl. Acad. Sci. U.S.A. 107, 11912-11917 (2010).
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 11912-11917
    • Sinai, P.1    Nguyen, C.2    Schatzle, J.D.3    Wülfing, C.4
  • 36
    • 38049136514 scopus 로고    scopus 로고
    • Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells
    • Y. Kaizuka, A. D. Douglass, R. Varma, M. L. Dustin, R. D. Vale, Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc. Natl. Acad. Sci. U.S.A. 104, 20296-20301 (2007).
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 20296-20301
    • Kaizuka, Y.1    Douglass, A.D.2    Varma, R.3    Dustin, M.L.4    Vale, R.D.5
  • 37
    • 33746011209 scopus 로고    scopus 로고
    • T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    • R. Varma, G. Campi, T. Yokosuka, T. Saito, M. L. Dustin, T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 25, 117-127 (2006).
    • (2006) Immunity , vol.25 , pp. 117-127
    • Varma, R.1    Campi, G.2    Yokosuka, T.3    Saito, T.4    Dustin, M.L.5
  • 39
    • 74049157769 scopus 로고    scopus 로고
    • TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
    • B. F. Lillemeier, M. A. Mortelmaier, M. B. Forstner, J. B. Huppa, J. T. Groves, M. M. Davis, TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nat. Immunol. 11, 90-96 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 90-96
    • Lillemeier, B.F.1    Mortelmaier, M.A.2    Forstner, M.B.3    Huppa, J.B.4    Groves, J.T.5    Davis, M.M.6
  • 40
    • 0036856493 scopus 로고    scopus 로고
    • Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells
    • N. Bortoletto, E. Scotet, Y. Myamoto, U. D'Oro, A. Lanzavecchia, Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells. Eur. J. Immunol. 32, 3102-3107 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 3102-3107
    • Bortoletto, N.1    Scotet, E.2    Myamoto, Y.3    D'Oro, U.4    Lanzavecchia, A.5
  • 42
    • 68849090313 scopus 로고    scopus 로고
    • Mechanisms and functions for the duration of intercellular contacts made by lymphocytes
    • D. M. Davis, Mechanisms and functions for the duration of intercellular contacts made by lymphocytes. Nat. Rev. Immunol. 9, 543-555 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 543-555
    • Davis, D.M.1
  • 43
  • 44
    • 0034176856 scopus 로고    scopus 로고
    • Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease
    • G. L. Costa, J. M. Benson, C. M. Seroogy, P. Achacoso, C. G. Fathman, G. P. Nolan, Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease. J. Immunol. 164, 3581-3590 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 3581-3590
    • Costa, G.L.1    Benson, J.M.2    Seroogy, C.M.3    Achacoso, P.4    Fathman, C.G.5    Nolan, G.P.6
  • 46
    • 80053494855 scopus 로고    scopus 로고
    • note
    • Acknowledgments: We thank L. Berg for Itk mutant constructs, J. Albanesi and G. Koretzky for the myosin 1C and SLP-76 GFP fusion proteins, and C. Happel and A. Hughson for technical help. Funding: The work was supported by grants from the NIH (to C.W., A.A., and D.J.F.) and the Medical Research Council (to V.L.J.T.). Author contributions: K.L.S. and C.W. designed the experiments; K.L.S., M.G., R.D.D., and C.W. executed the experiments and analyzed the data; B.B.A.-Y., O.K., V.L.J.T., A.A., and D.J.F. provided key reagents; V.L.J.T., A.A., and D.J.F. provided input in the preparation of the manuscript; and C.W. wrote the paper. Competing interests: The authors declare that they have no competing interests.


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