Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B)

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 4, 2004, Pages 891-895

  Tjernberg, Agneta ^a,b   Hallén, Dan ^a   Schultz, Johan ^a   James, Stephen ^a   Benkestock, Kurt ^a   Byström, Styrbjörn ^a   Weigelt, Johan ^a  

^a BIOVITRUM AB   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Enzyme inhibition; Irreversible oxidation; Mechanism of action; Reducing agent

Indexed keywords

CYSTEINE; HYDROGEN PEROXIDE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; PYRIDAZINE DERIVATIVE; REDUCING AGENT;

ARTICLE; CALORIMETRY; CATALYSIS; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; ISOTHERMAL TITRATION CALORIMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; OXIDATION REDUCTION REACTION;

EID: 0842302977     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.014     Document Type: Article

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