Expression of the rae-1 family of stimulatory nk-cell ligands requires activation of the pi3k pathway during viral infection and transformation

PLoS Pathogens

Volumn 7, Issue 9, 2011, Pages

  Tokuyama, Maria ^a   Lorin, Clarisse ^a,b   Delebecque, Frederic ^a,c   Jung, Heiyoun ^a   Raulet, David H ^a   Coscoy, Laurent ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURFURYLIDENE] 2,4 THIAZOLIDINEDIONE; 7 HYDROXYSTAUROSPORINE; 9 (1 ANILINOETHYL) 7 METHYL 2 MORPHOLINOPYRIDO[1,2 A]PYRIMIDIN 4 ONE; MESSENGER RNA; NATURAL KILLER CELL RECEPTOR NKG2D; NU 7026; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P110; PROTEIN RAE 1; RAPAMYCIN; SB 218078; SB 600125; UNCLASSIFIED DRUG; 1 PHOSPHATIDYLINOSITOL 3 KINASE P110 SUBUNIT, MOUSE; 1-PHOSPHATIDYLINOSITOL 3-KINASE P110 SUBUNIT, MOUSE; KLRK1 PROTEIN, MOUSE; LIGAND; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; NATURAL KILLER CELL RECEPTOR; NUCLEAR MATRIX PROTEIN; NUCLEOCYTOPLASMIC TRANSPORT PROTEIN; RAE1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CELL STRESS; CELL SURFACE; CYTOMEGALOVIRUS INFECTION; DNA DAMAGE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVE SITE; FIBROBLAST; GENE EXPRESSION; LIGAND BINDING; MOUSE; NATURAL KILLER CELL; NONHUMAN; OUTCOME ASSESSMENT; SIGNAL TRANSDUCTION; VIRAL GENETICS; VIRUS ATTACHMENT; VIRUS CELL TRANSFORMATION; VIRUS INHIBITION; ANIMAL; BIOSYNTHESIS; IMMUNOLOGY; METABOLISM; MUROMEGALOVIRUS; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VIROLOGY;

MURID HERPESVIRUS 1;

ANIMALS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL TRANSFORMATION, VIRAL; CYTOMEGALOVIRUS INFECTIONS; FIBROBLASTS; KILLER CELLS, NATURAL; LIGANDS; MICE; MUROMEGALOVIRUS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, NATURAL KILLER CELL;

EID: 80053438833     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002265     Document Type: Article

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