Role of the transmembrane domain 4/extracellular loop 2 junction of the human gonadotropin-releasing hormone receptor in ligand binding and receptor conformational selection

Journal of Biological Chemistry

Volumn 286, Issue 40, 2011, Pages 34617-34626

  Forfar, Rachel ^a   Lu, Zhi Liang ^b  

^a Centre for Therapeutics Discovery   (United Kingdom)

^b XI AN JIAOTONG LIVERPOOL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE MUTATIONS; CONFORMATIONAL SELECTION; CONFORMATIONAL SWITCHES; EXTRACELLULAR LOOP 2; FUNCTIONAL TYPES; G PROTEIN COUPLED RECEPTORS; GONADOTROPIN-RELEASING HORMONE; INTERMOLECULAR CONTACTS; LIGAND BINDING; LIGAND STRUCTURE; PEPTIDE LIGAND; PHOSPHOLIPID BILAYER; SIDE-CHAINS; STRUCTURAL DIVERSITY; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE DOMAIN;

ACTIVATION ANALYSIS; AMINO ACIDS; PHOSPHOLIPIDS;

LIGANDS;

EXTRACELLULAR LOOP 2 PROTEIN; GLUTAMINE; GONADORELIN RECEPTOR; ISOLEUCINE; LEUCINE; MEMBRANE PROTEIN; METHIONINE; PHENYLALANINE; PROLINE; TRANSMEMBRANE DOMAIN 4 PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; MUTAGENESIS; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; GTP-BINDING PROTEINS; HUMANS; HYDROGEN BONDING; INOSITOL PHOSPHATES; LIGANDS; LIPID BILAYERS; MOLECULAR DYNAMICS SIMULATION; PEPTIDE HORMONES; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LHRH; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053423102     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.240341     Document Type: Article

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