Refolding of misfolded mutant GPCR: Post-translational pharmacoperone action in vitro

Molecular and Cellular Endocrinology

Volumn 272, Issue 1-2, 2007, Pages 77-85

  Janovick, Jo Ann ^a   Brothers, Shaun P ^a,b   Cornea, Anda ^a   Bush, Eugene ^c   Goulet, Mark T ^d   Ashton, Wallace T ^d   Sauer, Daryl R ^c   Haviv, Fortuna ^c   Greer, Jonathan ^c   Michael Conn, P ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c ABBOTT LABORATORIES   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

G protein coupled receptor; Hypogonadotropic hypogonadism; Protein folding; Protein trafficking

Indexed keywords

GONADORELIN;

ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; QUALITY CONTROL;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CERCOPITHECUS AETHIOPS; COS CELLS; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; INDOLES; INOSITOL; MOLECULAR CHAPERONES; MOLECULAR MIMICRY; MUTANT PROTEINS; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PYRIDINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LHRH; TRANSFECTION;

EID: 34250172768     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.04.012     Document Type: Article

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