메뉴 건너뛰기




Volumn 22, Issue 11, 2008, Pages 2520-2530

A crucial role for Gαq/11, but not Gαi/o or Gαs, in gonadotropin-releasing hormone receptor-mediated cell growth inhibition

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GONADORELIN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; RECOMBINANT PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 55049087495     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2008-0122     Document Type: Article
Times cited : (22)

References (72)
  • 2
    • 0032052309 scopus 로고    scopus 로고
    • Effects of LHRH-analogues on mitogenic signal transduction in cancer cells
    • Emons G, Muller V, Ortmann O, Schulz KD 1998 Effects of LHRH-analogues on mitogenic signal transduction in cancer cells. J Steroid Biochem Mol Biol 65:199-206
    • (1998) J Steroid Biochem Mol Biol , vol.65 , pp. 199-206
    • Emons, G.1    Muller, V.2    Ortmann, O.3    Schulz, K.D.4
  • 3
    • 0025084464 scopus 로고
    • Expression of gonadotropin-releasing hormone and prothymosin-α messenger ribonucleic acid in the ovary
    • Oikawa M, Dargan C, Ny T, Hsueh AJ 1990 Expression of gonadotropin-releasing hormone and prothymosin-α messenger ribonucleic acid in the ovary. Endocrinology 127:2350-2356
    • (1990) Endocrinology , vol.127 , pp. 2350-2356
    • Oikawa, M.1    Dargan, C.2    Ny, T.3    Hsueh, A.J.4
  • 4
    • 0028364470 scopus 로고
    • The gene for the neuropeptide gonadotropin-releasing hormone is expressed in the mammary gland of lactating rats
    • Palmon A, Ben Aroya N, Tel-Or S, Burstein Y, Fridkin M, Koch Y 1994 The gene for the neuropeptide gonadotropin-releasing hormone is expressed in the mammary gland of lactating rats. Proc Natl Acad Sci USA 91:4994-4996
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4994-4996
    • Palmon, A.1    Ben Aroya, N.2    Tel-Or, S.3    Burstein, Y.4    Fridkin, M.5    Koch, Y.6
  • 5
    • 0027532290 scopus 로고
    • Characterization of binding sites for a GnRH-agonist (buserelin) in human breast cancer biopsies and their distribution in relation to tumor parameters
    • Baumann KH, Kiesel L, Kaufmann M, Bastert G, Runnebaum B 1993 Characterization of binding sites for a GnRH-agonist (buserelin) in human breast cancer biopsies and their distribution in relation to tumor parameters. Breast Cancer Res Treat 25:37-46
    • (1993) Breast Cancer Res Treat , vol.25 , pp. 37-46
    • Baumann, K.H.1    Kiesel, L.2    Kaufmann, M.3    Bastert, G.4    Runnebaum, B.5
  • 6
    • 0028586112 scopus 로고
    • The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary
    • Kakar SS, Grizzle WE, Neill JD 1994 The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary. Mol Cell Endocrinol 106:145-149
    • (1994) Mol Cell Endocrinol , vol.106 , pp. 145-149
    • Kakar, S.S.1    Grizzle, W.E.2    Neill, J.D.3
  • 7
    • 0036726665 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone receptor expression in primary breast cancer: Comparison of immunohistochemical, radioligand and Western blot analyses
    • Mangia A, Tommasi S, Reshkin SJ, Simone G, Stea B, Schittulli F, Paradiso A 2002 Gonadotropin-releasing hormone receptor expression in primary breast cancer: comparison of immunohistochemical, radioligand and Western blot analyses. Oncol Rep 9:1127-1132
    • (2002) Oncol Rep , vol.9 , pp. 1127-1132
    • Mangia, A.1    Tommasi, S.2    Reshkin, S.J.3    Simone, G.4    Stea, B.5    Schittulli, F.6    Paradiso, A.7
  • 8
    • 0028854196 scopus 로고
    • Expression of the messenger RNAs for luteinizing hormone-releasing hormone (LHRH) and its receptor in human ovarian epithelial carcinoma
    • Irmer G, Burger C, Muller R, Ortmann O, Peter U, Kakar SS, Neill JD, Schulz KD, Emons G 1995 Expression of the messenger RNAs for luteinizing hormone-releasing hormone (LHRH) and its receptor in human ovarian epithelial carcinoma. Cancer Res 55:817-822
    • (1995) Cancer Res , vol.55 , pp. 817-822
    • Irmer, G.1    Burger, C.2    Muller, R.3    Ortmann, O.4    Peter, U.5    Kakar, S.S.6    Neill, J.D.7    Schulz, K.D.8    Emons, G.9
  • 10
    • 0033303530 scopus 로고    scopus 로고
    • The luteinizing hormone-releasing hormone receptor in human prostate cancer cells: Messenger ribonucleic acid expression, molecular size, and signal transduction pathway
    • Limonta P, Moretti RM, Marelli MM, Dondi D, Parenti M, Motta M 1999 The luteinizing hormone-releasing hormone receptor in human prostate cancer cells: messenger ribonucleic acid expression, molecular size, and signal transduction pathway. Endocrinology 140:5250-5256
    • (1999) Endocrinology , vol.140 , pp. 5250-5256
    • Limonta, P.1    Moretti, R.M.2    Marelli, M.M.3    Dondi, D.4    Parenti, M.5    Motta, M.6
  • 11
    • 0020086031 scopus 로고
    • Treatment with a luteinising hormone-releasing hormone analogue (buserelin) in pre-menopausal patients with metastatic breast cancer
    • Klijn JG, de Jong FH 1982 Treatment with a luteinising hormone-releasing hormone analogue (buserelin) in pre-menopausal patients with metastatic breast cancer. Lancet 1:1213-1216
    • (1982) Lancet , vol.1 , pp. 1213-1216
    • Klijn, J.G.1    de Jong, F.H.2
  • 12
    • 0027941068 scopus 로고
    • Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: Evidence for an autocrine-inhibitory LHRH loop
    • Dondi D, Limonta P, Moretti RM, Marelli MM, Garattini E, Motta M 1994 Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res 54:4091-4095
    • (1994) Cancer Res , vol.54 , pp. 4091-4095
    • Dondi, D.1    Limonta, P.2    Moretti, R.M.3    Marelli, M.M.4    Garattini, E.5    Motta, M.6
  • 13
    • 0028203309 scopus 로고
    • Inhibition of human epithelial ovarian cancer cell growth in vitro by agonistic and antagonistic analogues of luteinizing hormone-releasing hormone
    • Yano T, Pinski J, Radulovic S, Schally AV 1994 Inhibition of human epithelial ovarian cancer cell growth in vitro by agonistic and antagonistic analogues of luteinizing hormone-releasing hormone. Proc Natl Acad Sci USA 91:1701-1705
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1701-1705
    • Yano, T.1    Pinski, J.2    Radulovic, S.3    Schally, A.V.4
  • 15
    • 0031960297 scopus 로고    scopus 로고
    • Growth-inhibitory effects of luteinizing hormone-releasing hormone (LHRH) agonists on xenografts of the DU 145 human androgen-independent prostate cancer cell line in nude mice
    • Dondi D, Moretti RM, Montagnani Marelli M, Pratesi G, Polizzi D, Milani M, Motta M, Limonta P 1998 Growth-inhibitory effects of luteinizing hormone-releasing hormone (LHRH) agonists on xenografts of the DU 145 human androgen-independent prostate cancer cell line in nude mice. Int J Cancer 76:506-511
    • (1998) Int J Cancer , vol.76 , pp. 506-511
    • Dondi, D.1    Moretti, R.M.2    Montagnani Marelli, M.3    Pratesi, G.4    Polizzi, D.5    Milani, M.6    Motta, M.7    Limonta, P.8
  • 16
    • 4143145476 scopus 로고    scopus 로고
    • 2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways
    • 2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways. Cancer Res 64:5736-5744
    • (2004) Cancer Res , vol.64 , pp. 5736-5744
    • Kraus, S.1    Levy, G.2    Hanoch, T.3    Naor, Z.4    Seger, R.5
  • 18
    • 19944405794 scopus 로고    scopus 로고
    • Evidence that prostate gonadotropin-releasing hormone receptors mediate an antitumourigenic response to analogue therapy in hormone refractory prostate cancer
    • Gnanapragasam VJ, Darby S, Khan MM, Lock WG, Robson CN, Leung HY 2005 Evidence that prostate gonadotropin-releasing hormone receptors mediate an antitumourigenic response to analogue therapy in hormone refractory prostate cancer. J Pathol 206:205-213
    • (2005) J Pathol , vol.206 , pp. 205-213
    • Gnanapragasam, V.J.1    Darby, S.2    Khan, M.M.3    Lock, W.G.4    Robson, C.N.5    Leung, H.Y.6
  • 19
    • 50649125221 scopus 로고    scopus 로고
    • Antiproliferative effects of GnRH agonists: Prospects and problems for cancer therapy
    • White CD, Stewart AJ, Lu ZL, Millar RP, Morgan K 2008 Antiproliferative effects of GnRH agonists: prospects and problems for cancer therapy. Neuroendocrinology 88:67-79
    • (2008) Neuroendocrinology , vol.88 , pp. 67-79
    • White, C.D.1    Stewart, A.J.2    Lu, Z.L.3    Millar, R.P.4    Morgan, K.5
  • 20
    • 0032723879 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line
    • Kimura A, Ohmichi M, Kurachi H, Ikegami H, Hayakawa J, Tasaka K, Kanda Y, Nishio Y, Jikihara H, Matsuura N, Murata Y 1999 Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line. Cancer Res 59:5133-5142
    • (1999) Cancer Res , vol.59 , pp. 5133-5142
    • Kimura, A.1    Ohmichi, M.2    Kurachi, H.3    Ikegami, H.4    Hayakawa, J.5    Tasaka, K.6    Kanda, Y.7    Nishio, Y.8    Jikihara, H.9    Matsuura, N.10    Murata, Y.11
  • 22
    • 0032230247 scopus 로고    scopus 로고
    • Stimulation of jun-N-terminal kinase (JNK) by gonadotropin- releasing hormone in pituitary αT3-1 cell line is mediated by protein kinase C, c-Src and CDC42
    • Levi NL, Hanoch T, Benard O, Rozenblat M, Harris D, Reiss N, Naor Z, Seger R 1998 Stimulation of jun-N-terminal kinase (JNK) by gonadotropin- releasing hormone in pituitary αT3-1 cell line is mediated by protein kinase C, c-Src and CDC42. Mol Endocrinol 12:815-824
    • (1998) Mol Endocrinol , vol.12 , pp. 815-824
    • Levi, N.L.1    Hanoch, T.2    Benard, O.3    Rozenblat, M.4    Harris, D.5    Reiss, N.6    Naor, Z.7    Seger, R.8
  • 23
    • 0032963917 scopus 로고    scopus 로고
    • Activation of the P38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone
    • Roberson MS, Zhang T, Li HL, Mulvaney JM 1999 Activation of the P38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone. Endocrinology 140:1310-1318
    • (1999) Endocrinology , vol.140 , pp. 1310-1318
    • Roberson, M.S.1    Zhang, T.2    Li, H.L.3    Mulvaney, J.M.4
  • 24
    • 0034119581 scopus 로고    scopus 로고
    • Activation of MAPK cascades by G protein-coupled receptors: The case of gonadotropin-releasing hormone receptor
    • Naor Z, Benard O, Seger R 2000 Activation of MAPK cascades by G protein-coupled receptors: the case of gonadotropin-releasing hormone receptor. Trends Endocrinol Metab 11:91-99
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 91-99
    • Naor, Z.1    Benard, O.2    Seger, R.3
  • 25
    • 0036173664 scopus 로고    scopus 로고
    • Activation of MAPK cascades by GnRH: ERK and jun-N-terminal kinase are involved in basal and GnRH-stimulated activity of the glycoprotein hormone LHβ-subunit promoter
    • Harris D, Bonfil D, Chuderland D, Kraus S, Seger R, Naor Z 2002 Activation of MAPK cascades by GnRH: ERK and jun-N-terminal kinase are involved in basal and GnRH-stimulated activity of the glycoprotein hormone LHβ-subunit promoter. Endocrinology 143:1018-1025
    • (2002) Endocrinology , vol.143 , pp. 1018-1025
    • Harris, D.1    Bonfil, D.2    Chuderland, D.3    Kraus, S.4    Seger, R.5    Naor, Z.6
  • 27
    • 0029816592 scopus 로고    scopus 로고
    • Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors
    • Imai A, Takagi H, Horibe S, Fuseya T, Tamaya T 1996 Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors. J Clin Endocrinol Metab 81:3249-3253
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3249-3253
    • Imai, A.1    Takagi, H.2    Horibe, S.3    Fuseya, T.4    Tamaya, T.5
  • 28
    • 0035020249 scopus 로고    scopus 로고
    • i-mediated activation of phosphotyrosine phosphatase
    • i-mediated activation of phosphotyrosine phosphatase. Endocrinology 142:2369-2380
    • (2001) Endocrinology , vol.142 , pp. 2369-2380
    • Grundker, C.1    Volker, P.2    Emons, G.3
  • 29
    • 0036164170 scopus 로고    scopus 로고
    • Biology of the gonadotropin-releasing hormone system in gynecological cancers
    • Grundker C, Gunthert AR, Westphalen S, Emons G 2002 Biology of the gonadotropin-releasing hormone system in gynecological cancers. Eur J Endocrinol 146:1-14
    • (2002) Eur J Endocrinol , vol.146 , pp. 1-14
    • Grundker, C.1    Gunthert, A.R.2    Westphalen, S.3    Emons, G.4
  • 30
    • 0347320615 scopus 로고    scopus 로고
    • The biology of gonadotropin hormone-releasing hormone: Role in the control of tumor growth and progression in humans
    • Limonta P, Moretti RM, Marelli MM, Motta M 2003 The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans. Front Neuroendocrinol 24:279-295
    • (2003) Front Neuroendocrinol , vol.24 , pp. 279-295
    • Limonta, P.1    Moretti, R.M.2    Marelli, M.M.3    Motta, M.4
  • 31
    • 0031038565 scopus 로고    scopus 로고
    • Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines
    • Kaiser UB, Conn PM, Chin WW 1997 Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocr Rev 18:46-70
    • (1997) Endocr Rev , vol.18 , pp. 46-70
    • Kaiser, U.B.1    Conn, P.M.2    Chin, W.W.3
  • 33
    • 0021971578 scopus 로고
    • Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist
    • Miller WR, Scott WN, Morris R, Fraser HM, Sharpe RM 1985 Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist. Nature 313:231-233
    • (1985) Nature , vol.313 , pp. 231-233
    • Miller, W.R.1    Scott, W.N.2    Morris, R.3    Fraser, H.M.4    Sharpe, R.M.5
  • 35
    • 0043235844 scopus 로고    scopus 로고
    • Ligand-selective receptor conformations revisited: The promise and the problem
    • Kenakin T 2003 Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol Sci 24:346-354
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 346-354
    • Kenakin, T.1
  • 38
    • 0030046378 scopus 로고    scopus 로고
    • Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: Evidence for the involvement of protein kinase C
    • Sundaresan S, Colin IM, Pestell RG, Jameson JL 1996 Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: evidence for the involvement of protein kinase C. Endocrinology 137:304-311
    • (1996) Endocrinology , vol.137 , pp. 304-311
    • Sundaresan, S.1    Colin, I.M.2    Pestell, R.G.3    Jameson, J.L.4
  • 39
    • 0029127706 scopus 로고
    • Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and a pertussis toxin-sensitive G protein
    • Sim PJ, Wolbers WB, Mitchell R 1995 Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and a pertussis toxin-sensitive G protein. Mol Cell Endocrinol 112:257-263
    • (1995) Mol Cell Endocrinol , vol.112 , pp. 257-263
    • Sim, P.J.1    Wolbers, W.B.2    Mitchell, R.3
  • 41
    • 0028925917 scopus 로고
    • 11α (pertussis toxin-insensitive) G proteins in αT3-1 gonadotroph cells reflects increased G protein turnover but not alterations in mRNA levels
    • 11α (pertussis toxin-insensitive) G proteins in αT3-1 gonadotroph cells reflects increased G protein turnover but not alterations in mRNA levels. Proc Natl Acad Sci USA 92:1886-1890
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1886-1890
    • Shah, B.H.1    MacEwan, D.J.2    Milligan, G.3
  • 42
    • 36448956774 scopus 로고    scopus 로고
    • GPCR-jacking: From a new route in RTK signaling to a new concept in GPCR activation
    • Delcourt N, Bockaert J, Marin P 2007 GPCR-jacking: from a new route in RTK signaling to a new concept in GPCR activation. Trends Pharmacol Sci 28:602-607
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 602-607
    • Delcourt, N.1    Bockaert, J.2    Marin, P.3
  • 43
    • 0037418302 scopus 로고    scopus 로고
    • An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion
    • Krsmanovic LZ, Mores N, Navarro CE, Arora KK, Catt KJ 2003 An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion. Proc Natl Acad Sci USA 100:2969-2974
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2969-2974
    • Krsmanovic, L.Z.1    Mores, N.2    Navarro, C.E.3    Arora, K.K.4    Catt, K.J.5
  • 44
    • 0027216213 scopus 로고
    • A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: Loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone
    • Janovick JA, Conn PM 1993 A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone. Endocrinology 132:2131-2135
    • (1993) Endocrinology , vol.132 , pp. 2131-2135
    • Janovick, J.A.1    Conn, P.M.2
  • 45
    • 0024511978 scopus 로고
    • Cyclic adenosine monophosphate and phorbol ester, like gonadotropin-releasing hormone, stimulate the biosynthesis of luteinizing hormone polypeptide chains in a nonadditive manner
    • Starzec A, Jutisz M, Counis R 1989 Cyclic adenosine monophosphate and phorbol ester, like gonadotropin-releasing hormone, stimulate the biosynthesis of luteinizing hormone polypeptide chains in a nonadditive manner. Mol Endocrinol 3:618-624
    • (1989) Mol Endocrinol , vol.3 , pp. 618-624
    • Starzec, A.1    Jutisz, M.2    Counis, R.3
  • 46
    • 1542270971 scopus 로고    scopus 로고
    • The cAMP signaling system regulates LHβ gene expression: Roles of early growth response protein-1, SP1 and steroidogenic factor-1
    • Horton CD, Halvorson LM 2004 The cAMP signaling system regulates LHβ gene expression: roles of early growth response protein-1, SP1 and steroidogenic factor-1. J Mol Endocrinol 32:291-306
    • (2004) J Mol Endocrinol , vol.32 , pp. 291-306
    • Horton, C.D.1    Halvorson, L.M.2
  • 47
    • 0031877855 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: Evidence from palmitoylation and overexpression of G proteins
    • Stanislaus D, Ponder S, Ji TH, Conn PM 1998 Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins. Biol Reprod 59:579-586
    • (1998) Biol Reprod , vol.59 , pp. 579-586
    • Stanislaus, D.1    Ponder, S.2    Ji, T.H.3    Conn, P.M.4
  • 49
    • 33847084653 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone couples to 3′,5′-cyclic adenosine-5′-monophosphate pathway through novel protein kinase Cδ and ε in LβT2 gonadotrope cells
    • Lariviere S, Garrel G, Simon V, Soh JW, Laverriere JN, Counis R, Cohen-Tannoudji J 2007 Gonadotropin-releasing hormone couples to 3′,5′-cyclic adenosine-5′-monophosphate pathway through novel protein kinase Cδ and ε in LβT2 gonadotrope cells. Endocrinology 148:1099-1107
    • (2007) Endocrinology , vol.148 , pp. 1099-1107
    • Lariviere, S.1    Garrel, G.2    Simon, V.3    Soh, J.W.4    Laverriere, J.N.5    Counis, R.6    Cohen-Tannoudji, J.7
  • 50
    • 0037036413 scopus 로고    scopus 로고
    • s-coupled receptor signaling pathways
    • s-coupled receptor signaling pathways. J Biol Chem 277:21080-21085
    • (2002) J Biol Chem , vol.277 , pp. 21080-21085
    • Berlot, C.H.1
  • 52
    • 34447099952 scopus 로고    scopus 로고
    • New insights into the regulation of cAMP synthesis beyond GPCR/G protein activation: Implications in cardiovascular regulation
    • Feldman RD, Gros R 2007 New insights into the regulation of cAMP synthesis beyond GPCR/G protein activation: implications in cardiovascular regulation. Life Sci 81:267-271
    • (2007) Life Sci , vol.81 , pp. 267-271
    • Feldman, R.D.1    Gros, R.2
  • 53
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signaling pathways in cancer
    • Dhillon AS, Hagan S, Rath O, Kolch W 2007 MAP kinase signaling pathways in cancer. Oncogene 26:3279-3290
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 56
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • Raman M, Chen W, Cobb MH 2007 Differential regulation and properties of MAPKs. Oncogene 26:3100-3112
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 57
    • 33646014459 scopus 로고    scopus 로고
    • Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: Role of the GnRH-I receptor and protein kinase C pathway
    • Kim KY, Choi KC, Auersperg N, Leung PC 2006 Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway. Endocr Relat Cancer 13:211-220
    • (2006) Endocr Relat Cancer , vol.13 , pp. 211-220
    • Kim, K.Y.1    Choi, K.C.2    Auersperg, N.3    Leung, P.C.4
  • 58
    • 13444293451 scopus 로고    scopus 로고
    • Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells
    • Goulet AC, Chigbrow M, Frisk P, Nelson MA 2005 Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells. Carcinogenesis 26:109-117
    • (2005) Carcinogenesis , vol.26 , pp. 109-117
    • Goulet, A.C.1    Chigbrow, M.2    Frisk, P.3    Nelson, M.A.4
  • 59
    • 33646503474 scopus 로고    scopus 로고
    • Activation of protein kinase Cδ induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase
    • Koike K, Fujii T, Nakamura AM, Yokoyama G, Yamana H, Kuwano M, Shirouzu K 2006 Activation of protein kinase Cδ induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase. Thyroid 16:333-341
    • (2006) Thyroid , vol.16 , pp. 333-341
    • Koike, K.1    Fujii, T.2    Nakamura, A.M.3    Yokoyama, G.4    Yamana, H.5    Kuwano, M.6    Shirouzu, K.7
  • 60
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ 1995 Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 62
    • 0031028381 scopus 로고    scopus 로고
    • Cell-cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
    • Pumiglia KM, Decker SJ 1997 Cell-cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 94:448-452
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 448-452
    • Pumiglia, K.M.1    Decker, S.J.2
  • 63
    • 0030871667 scopus 로고    scopus 로고
    • High-intensity Raf signal causes cell-cycle arrest mediated by p21Cip1
    • Sewing A, Wiseman B, Lloyd AC, Land H 1997 High-intensity Raf signal causes cell-cycle arrest mediated by p21Cip1. Mol Cell Biol 17:5588-5597
    • (1997) Mol Cell Biol , vol.17 , pp. 5588-5597
    • Sewing, A.1    Wiseman, B.2    Lloyd, A.C.3    Land, H.4
  • 64
    • 33751513018 scopus 로고    scopus 로고
    • Activin modulates the transcriptional response of LβT2 cells to gonadotropin-releasing hormone and alters cellular proliferation
    • Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ 2006 Activin modulates the transcriptional response of LβT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol 20:2909-2930
    • (2006) Mol Endocrinol , vol.20 , pp. 2909-2930
    • Zhang, H.1    Bailey, J.S.2    Coss, D.3    Lin, B.4    Tsutsumi, R.5    Lawson, M.A.6    Mellon, P.L.7    Webster, N.J.8
  • 65
    • 0035171066 scopus 로고    scopus 로고
    • Protein kinase C-independent stimulation of activator protein-1 and c-Jun-N-terminal kinase activity in human endometrial cancer cells by the LHRH agonist triptorelin
    • Grundker C, Schlotawa L, Viereck V, Emons G 2001 Protein kinase C-independent stimulation of activator protein-1 and c-Jun-N-terminal kinase activity in human endometrial cancer cells by the LHRH agonist triptorelin. Eur J Endocrinol 145:651-658
    • (2001) Eur J Endocrinol , vol.145 , pp. 651-658
    • Grundker, C.1    Schlotawa, L.2    Viereck, V.3    Emons, G.4
  • 66
    • 23844481788 scopus 로고    scopus 로고
    • Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: Evidence for ligand-selective, receptor-active conformations
    • Lu ZL, Gallagher R, Sellar R, Coetsee M, Millar RP 2005 Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptor-active conformations. J Biol Chem 280:29796-29803
    • (2005) J Biol Chem , vol.280 , pp. 29796-29803
    • Lu, Z.L.1    Gallagher, R.2    Sellar, R.3    Coetsee, M.4    Millar, R.P.5
  • 67
    • 34547096510 scopus 로고    scopus 로고
    • Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor
    • Lu ZL, Coetsee M, White CD, Millar RP 2007 Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor. J Biol Chem 282:17921-17929
    • (2007) J Biol Chem , vol.282 , pp. 17921-17929
    • Lu, Z.L.1    Coetsee, M.2    White, C.D.3    Millar, R.P.4
  • 68
    • 0345826089 scopus 로고    scopus 로고
    • Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor
    • Davidson L, Pawson AJ, Millar RP, Maudsley S 2004 Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor. J Biol Chem 279:1980-1993
    • (2004) J Biol Chem , vol.279 , pp. 1980-1993
    • Davidson, L.1    Pawson, A.J.2    Millar, R.P.3    Maudsley, S.4
  • 69
    • 1642564476 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase ζ and its association with active c-Src
    • Davidson L, Pawson AJ, de Maturana RL, Freestone SH, Barran P, Millar RP, Maudsley S 2004 Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase ζ and its association with active c-Src. J Biol Chem 279:11906-11916
    • (2004) J Biol Chem , vol.279 , pp. 11906-11916
    • Davidson, L.1    Pawson, A.J.2    de Maturana, R.L.3    Freestone, S.H.4    Barran, P.5    Millar, R.P.6    Maudsley, S.7
  • 71
    • 0032586641 scopus 로고    scopus 로고
    • 35S]guanosine-5′-O-(3- thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay
    • 35S]guanosine-5′-O-(3- thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay. J Pharmacol Exp Ther 289:946-955
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 946-955
    • DeLapp, N.W.1    McKinzie, J.H.2    Sawyer, B.D.3    Vandergriff, A.4    Falcone, J.5    McClure, D.6    Felder, C.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.