Identification of Tyr290(6.58) of the human gonadotropin- releasing hormone (GnRH) receptor as a contact residue for both GnRH I and GnRH II: Importance for high-affinity binding and receptor activation

Biochemistry

Volumn 47, Issue 39, 2008, Pages 10305-10313

  Coetsee, Marla ^a,b   Millar, Robert P ^a,b   Flanagan, Colleen A ^b,c   Lu, Zhi Liang ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND MEDICAL SCHOOL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR MODELLING;

GONADORELIN RECEPTOR; TYROSINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HYDROGEN BOND; ISOTOPE LABELING; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; RADIOASSAY; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; BINDING, COMPETITIVE; GONADOTROPIN-RELEASING HORMONE; HISTIDINE; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; RECEPTORS, LHRH; TYROSINE;

EID: 52949146798     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800911z     Document Type: Article

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