-
2
-
-
0031838638
-
American Association for Cancer Research 1998: Promises and prospects for the next century
-
289610
-
(1998)
Expert Opin Invest Drugs
, vol.7
, Issue.6
, pp. 1015-1021
-
-
Lavelle, F.1
-
4
-
-
0000535592
-
Phase I clinical and pharmacokinetic trial of the farnesyltransferase inhibitor R115777 on a 21-day dosing schedule
-
326239; Abs 601; note
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
-
-
Hudes, G.R.1
Schol, J.2
Baab, J.3
Rogatko, A.4
Bol, C.5
Horak, I.6
Langer, C.7
Goldstein, L.J.8
Szarka, C.9
Meropol, N.J.10
Weiner, L.11
-
5
-
-
18544412314
-
A phase I and pharmacokinetic study of farnesyltransferase inhibitor, R-115777, in advanced cancer
-
327067; Abs 739
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
-
-
Zujewski, J.1
Horak, I.D.2
Bol, C.J.J.G.3
Woestenborghs, R.4
End, D.5
Chiao, J.6
Belly, R.T.7
Kohler, D.8
Chow, C.9
Noone, M.10
Hakim, F.T.11
Larkin, G.12
Gress, R.E.13
Nussenblatt, R.B.14
Kremer, A.B.15
Cowan, K.H.16
-
9
-
-
0000165190
-
Phase I and pharmacologic study with the novel farnesyltransferase inhibitor (FTI) R115777
-
369480; Abs 715; note
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
-
-
Schellens, J.H.M.1
De Klerk, G.2
Martha, S.3
Palmer, P.A.4
Bol, C.J.5
Van't Veer, L.J.6
Tan, S.7
De Gast, G.C.8
Beijnen, J.H.9
Ten Bokkel Huinink, W.W.10
-
10
-
-
18544412314
-
Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer
-
389037; note
-
(2000)
J Clin Oncol
, vol.18
, Issue.4
, pp. 927-941
-
-
Zujewski, J.1
Horak, I.D.2
Bol, C.J.3
Woestenborghs, R.4
Bowden, C.5
End, D.W.6
Piotrovsky, V.K.7
Chiao, J.8
Belly, R.T.9
Todd, A.10
Kopp, W.C.11
Kohler, D.R.12
Chow, C.13
Noone, M.14
Hakim, F.T.15
Larkin, G.16
Gress, R.E.17
Nussenblatt, R.B.18
Kremer, A.B.19
Cowan, K.H.20
more..
-
11
-
-
0008921510
-
Administration of biologically and clinically relevant doses of the farnesyltransferase inhibitor R115777 and gemcitabine are feasible without pharmacokinetic (PK) interactions: A phase I and PK study
-
389741; Abs 255; note
-
(2000)
NCI EORTC Symp New Drugs Cancer Ther
, vol.11
-
-
Patanak, A.1
Eckhardt, S.G.2
Izibicka, E.3
Rybak, M.4
McCreey, H.5
Rowinsky, E.6
Gentner, L.7
Bok, K.8
Terada, K.9
Mori, M.10
Davidson, K.11
Hammond, L.12
-
13
-
-
0008880222
-
A phase I, pharmacological and biological study of the farnesyltransferase inhibitor (FTI) R115777 and capecitabine in patients (pts) with advanced solid malignancies
-
391094; Abs 533
-
(2000)
NCI EORTC Symp New Drugs Cancer Ther
, vol.11
-
-
Holden, S.N.1
Cohen, R.2
Fisher, S.3
Persky, M.4
Mikule, C.5
Morrow, M.6
Richards, H.7
Rodriguez, S.8
Eckhardt, S.G.9
-
14
-
-
0008954661
-
Drug development pipeline: Johnson & Johnson
-
399065
-
(2001)
-
-
-
15
-
-
0000683061
-
Effects of R115777, a farnesyltransferase inhibitor (FTI), on methylnitrosourea (MNU)-induced mammary cancers: Role of HaRas mutation
-
404838; Abs 1399; note
-
(2001)
Proc Annu Meet Am Assoc Cancer Res
, vol.42
-
-
Lubet, R.A.1
You, M.2
Ruchon, Y.3
Wang, Y.4
End, D.W.5
Woulters, W.6
Christov, K.7
Grubbs, C.J.8
-
17
-
-
0000162961
-
A phase I pharmacokinetic (PK) and biological study of the farensyltransferase inhibitor (FTI) R115777 and capecitabine in patients (PTS) with advanced solid tumors
-
409862; Abs 316; note
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Holden, S.N.1
Eckhardt, S.2
Fisher, S.3
Persky, M.4
Mikule, C.5
O'Bryant, C.L.6
Morrow, M.7
Richards, H.8
Rodriguez, S.9
Bol, C.10
Cohen, R.11
-
18
-
-
0000023012
-
A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of the farnesyltransferase inhibitor (FTI) R115777 in Japanese patients with advanced non-hematological malignancies
-
409864; Abs 317; note
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Nakagawa, K.1
Yamamoto, N.2
Nishio, K.3
Ohashi, Y.4
End, D.5
Bol, K.6
Ito, H.7
Fukuoka, M.8
-
19
-
-
0000814480
-
A phase I trial of the farnesyltransferase inhibitor R115777, in combination with gemcitabine and cisplatin in patients with advanced cancer
-
409868; Abs 320; note
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Adjei, A.A.1
Erlichman, C.2
Marks, R.S.3
Croghan, G.A.4
Sloan, J.A.5
Hanson, L.J.6
Reid, J.M.7
Atherton, P.J.8
Pitot, H.C.9
Alberts, S.R.10
Seifert, W.F.11
Thibault, A.12
Kaufmann, S.H.13
-
20
-
-
0000318295
-
Enhanced myelosuppression of topotecan when combined with the farnesyltransferase inhibitor, R115777: A phase I and pharmacodynamic study
-
409871; Abs 321; note
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Liebes, L.1
Hochster, H.2
Speyer, J.3
Chachoua, A.4
Hamilton, A.5
Oratz, R.6
Pavlick, A.7
Sorich, J.8
Francois, A.9
Muggia, F.10
-
21
-
-
0000162962
-
A phase I, pharmacokinetic, and biologic correlative study of R115777 and trastuzumab (Herceptin) in patients with advanced cancer
-
409872; Abs 322; note
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Schwartz, G.1
Rowinsky, E.K.2
Rha, S.Y.3
Hammond, L.A.4
Smith, L.5
Patnaik, A.6
Hildalgo, M.7
Berg, K.8
Izbicka, E.9
Tolcher, A.W.10
-
23
-
-
0003232194
-
Phase I trial of R115777, an oral farnesyltransferase (FTase) inhibitor, in children with refractory solid tumors and neurofibromatosis type I (NF1)
-
410581; Abs 1467
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, pp. 1
-
-
Widemann, B.C.1
Salzler, W.L.2
Arcesi, R.J.3
Blaney, S.M.4
End, D.5
Bol, K.J.6
Palumbo, J.S.7
Gillespie, A.8
Whitcombe, T.9
Gentner, L.10
Jia, X.11
Richards, H.12
Thibault, A.13
Balis, F.M.14
-
27
-
-
0035132538
-
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
-
416502; note
-
(2001)
Cancer Res
, vol.61
, Issue.1
, pp. 131-137
-
-
End, D.W.1
Smets, G.2
Todd, A.V.3
Applegate, T.L.4
Fuery, C.J.5
Angibaud, P.6
Venet, M.7
Sanz, G.8
Poignet, H.9
Skrzat, S.10
Devine, A.11
-
28
-
-
0035383789
-
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical-laboratory correlative trial
-
416522
-
(2001)
Blood
, vol.97
, Issue.11
, pp. 3361-3369
-
-
Karp, J.E.1
Lancet, J.E.2
Kaufmann, T.J.3
Ange, D.4
Buddharaju, L.5
Gojo, I.6
Highsmith, W.E.7
Belly, R.T.8
Hohl, R.J.9
Rybak, M.E.10
Thibault, A.11
Rosenblatt, J.12
-
30
-
-
0008906806
-
Unexpected pharmacodynamics of the farnesyl protein transferase inhibitor
-
416531
-
(2000)
Proc Annu Meet Am Assoc Cancer Res
, vol.41
, pp. 220
-
-
Skrzat, S.G.1
Fanelli, L.2
Chevalier, K.3
Jacqmin, P.4
Van Beijsterveldt, L.5
De Vries, R.6
Wouters, W.7
End, D.W.8
-
31
-
-
0008906807
-
R115777 as farnesyl protein transferase inhibitor: Synthesis and SAR
-
419313; Abs MEDI 5; note
-
(2001)
ACS
, vol.222
-
-
Venet, M.1
-
32
-
-
0008920472
-
Drug development pipeline: L-778123, RY-023 and RY-024
-
422121; September 12
-
(2001)
Company Communication
-
-
-
35
-
-
0001133884
-
A phase I and pharmacokinetic (PK) study of the farnesyltransferase inhibitor, R115777 in combination with gemcitabine (Gem)
-
436546; Abs 5A
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
-
-
Patnaik, A.1
Eckhardt, S.G.2
Izbicka, E.3
Hildalgo, M.4
McCreery, H.5
Mori, M.6
Terada, K.7
Tolcher, A.8
Smith, L.9
Britten, C.10
Bowden, C.11
Bol, K.12
Ochoa, L.13
Davidson, K.14
Hammond, L.15
Schwartz, G.16
Gentner, L.17
Rowinsky, E.18
-
36
-
-
0001173323
-
Inhibition of HDJ2 protein farnesylation in peripheral blood mononuclear cells as a pharmacodynamic endpoint in a phase I study of R115777 and gemcitabine
-
436550; Abs 2682
-
(2001)
Proc Am Assoc Cancer Res
, vol.42
-
-
Patnaik, A.1
Izbicka, E.2
Eckhardt, S.G.3
Davidson, K.4
Goetz, A.5
McCreery, H.6
Tolcher, A.7
Mori, M.8
Terada, K.9
Bol, K.10
Rybak, M.11
Thibault, A.12
Richards, H.13
Gentner, L.14
Rowinsky, E.15
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