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Volumn 12, Issue , 2011, Pages

Ss-TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs

Author keywords

[No Author keywords available]

Indexed keywords

G-PROTEIN COUPLED RECEPTORS; HIGH-QUALITY SEQUENCES; LIGAND-BINDING RESIDUES; MULTIPLE SEQUENCE ALIGNMENTS; PHYSIOLOGICAL PROCESS; SEQUENCE CONSERVATION; SITE DIRECTED MUTAGENESIS; TRANSMEMBRANE DOMAIN;

EID: 80053324221     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-12-332     Document Type: Article
Times cited : (20)

References (57)
  • 1
    • 0037020329 scopus 로고    scopus 로고
    • Drug design strategies for targeting G-protein-coupled receptors
    • 10.1002/1439-7633(20021004)3:10<928::AID-CBIC928>3.0.CO;2-5, 12362358
    • Klabunde T, Hessler G. Drug design strategies for targeting G-protein-coupled receptors. ChemBioChem 2002, 3(10):928-944. 10.1002/1439-7633(20021004)3:10<928::AID-CBIC928>3.0.CO;2-5, 12362358.
    • (2002) ChemBioChem , vol.3 , Issue.10 , pp. 928-944
    • Klabunde, T.1    Hessler, G.2
  • 2
    • 0036717194 scopus 로고    scopus 로고
    • The druggable genome
    • 10.1038/nrd892, 12209152
    • Hopkins AL, Groom CR. The druggable genome. Nat Rev Drug Discov 2002, 1(9):727-730. 10.1038/nrd892, 12209152.
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.9 , pp. 727-730
    • Hopkins, A.L.1    Groom, C.R.2
  • 3
    • 0028174033 scopus 로고
    • Fingerprinting G-protein-coupled receptors
    • 10.1093/protein/7.2.195, 8170923
    • Attwood TK, Findlay JB. Fingerprinting G-protein-coupled receptors. Protein Eng 1994, 7(2):195-203. 10.1093/protein/7.2.195, 8170923.
    • (1994) Protein Eng , vol.7 , Issue.2 , pp. 195-203
    • Attwood, T.K.1    Findlay, J.B.2
  • 4
    • 0028338534 scopus 로고
    • GCRDb: a G-protein-coupled receptor database
    • Kolakowski LF. GCRDb: a G-protein-coupled receptor database. Receptors Channels 1994, 2(1):1-7.
    • (1994) Receptors Channels , vol.2 , Issue.1 , pp. 1-7
    • Kolakowski, L.F.1
  • 5
    • 0037252680 scopus 로고    scopus 로고
    • GPCRDB information system for G protein-coupled receptors
    • 10.1093/nar/gkg103, 165550, 12520006
    • Horn F, Bettler E, Oliveira L, Campagne F, Cohen FE, Vriend G. GPCRDB information system for G protein-coupled receptors. Nucleic Acids Res 2003, 31(1):294-297. 10.1093/nar/gkg103, 165550, 12520006.
    • (2003) Nucleic Acids Res , vol.31 , Issue.1 , pp. 294-297
    • Horn, F.1    Bettler, E.2    Oliveira, L.3    Campagne, F.4    Cohen, F.E.5    Vriend, G.6
  • 6
    • 33748671369 scopus 로고    scopus 로고
    • The 7 TM G-protein-coupled receptor target family
    • Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem 2006, 1(8):761-782.
    • (2006) ChemMedChem , vol.1 , Issue.8 , pp. 761-782
    • Jacoby, E.1    Bouhelal, R.2    Gerspacher, M.3    Seuwen, K.4
  • 8
    • 0036463901 scopus 로고    scopus 로고
    • Efficacy at G-protein-coupled receptors
    • 10.1038/nrd722, 12120091
    • Kenakin T. Efficacy at G-protein-coupled receptors. Nat Rev Drug Discov 2002, 1(2):103-110. 10.1038/nrd722, 12120091.
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.2 , pp. 103-110
    • Kenakin, T.1
  • 9
    • 0036490942 scopus 로고    scopus 로고
    • Allosteric binding sites on cell-surface receptors: novel targets for drug discovery
    • 10.1038/nrd746, 12120504
    • Christopoulos A. Allosteric binding sites on cell-surface receptors: novel targets for drug discovery. Nat Rev Drug Discov 2002, 1(3):198-210. 10.1038/nrd746, 12120504.
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.3 , pp. 198-210
    • Christopoulos, A.1
  • 10
    • 22944487986 scopus 로고    scopus 로고
    • Multiple signaling states of G-protein-coupled receptors
    • 10.1124/pr.57.2.2, 15914464
    • Perez DM, Karnik SS. Multiple signaling states of G-protein-coupled receptors. Pharmacol Rev 2005, 57(2):147-161. 10.1124/pr.57.2.2, 15914464.
    • (2005) Pharmacol Rev , vol.57 , Issue.2 , pp. 147-161
    • Perez, D.M.1    Karnik, S.S.2
  • 11
    • 22944452140 scopus 로고    scopus 로고
    • The origins of diversity and specificity in g protein-coupled receptor signaling
    • 10.1124/jpet.105.083121, 2656918, 15805429
    • Maudsley S, Martin B, Luttrell LM. The origins of diversity and specificity in g protein-coupled receptor signaling. J Pharmacol Exp Ther 2005, 314(2):485-494. 10.1124/jpet.105.083121, 2656918, 15805429.
    • (2005) J Pharmacol Exp Ther , vol.314 , Issue.2 , pp. 485-494
    • Maudsley, S.1    Martin, B.2    Luttrell, L.M.3
  • 13
    • 0035336676 scopus 로고    scopus 로고
    • Activation of rhodopsin: new insights from structural and biochemical studies
    • 10.1016/S0968-0004(01)01799-6, 11343925
    • Okada T, Ernst OP, Palczewski K, Hofmann KP. Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci 2001, 26(5):318-324. 10.1016/S0968-0004(01)01799-6, 11343925.
    • (2001) Trends Biochem Sci , vol.26 , Issue.5 , pp. 318-324
    • Okada, T.1    Ernst, O.P.2    Palczewski, K.3    Hofmann, K.P.4
  • 14
    • 0028845598 scopus 로고
    • An evolutionary view of drug-receptor interaction: the bioamine receptor family
    • 10.1016/S0165-6147(00)89078-1, 8578606
    • Vernier P, Cardinaud B, Valdenaire O, Philippe H, Vincent JD. An evolutionary view of drug-receptor interaction: the bioamine receptor family. Trends Pharmacol Sci 1995, 16(11):375-381. 10.1016/S0165-6147(00)89078-1, 8578606.
    • (1995) Trends Pharmacol Sci , vol.16 , Issue.11 , pp. 375-381
    • Vernier, P.1    Cardinaud, B.2    Valdenaire, O.3    Philippe, H.4    Vincent, J.D.5
  • 15
    • 0035209620 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • Fredholm BB, AP IJ, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 2001, 53(4):527-552.
    • (2001) Pharmacol Rev , vol.53 , Issue.4 , pp. 527-552
    • Fredholm, B.B.1    AP, I.J.2    Jacobson, K.A.3    Klotz, K.N.4    Linden, J.5
  • 17
    • 0034849509 scopus 로고    scopus 로고
    • Chemokine receptors
    • 10.1016/S1359-6101(01)00014-4, 11544102
    • Horuk R. Chemokine receptors. Cytokine Growth Factor Rev 2001, 12(4):313-335. 10.1016/S1359-6101(01)00014-4, 11544102.
    • (2001) Cytokine Growth Factor Rev , vol.12 , Issue.4 , pp. 313-335
    • Horuk, R.1
  • 18
    • 11844275233 scopus 로고    scopus 로고
    • A family of fatty acid binding receptors
    • 10.1089/dna.2005.24.54, 15684720
    • Brown AJ, Jupe S, Briscoe CP. A family of fatty acid binding receptors. DNA Cell Biol 2005, 24(1):54-61. 10.1089/dna.2005.24.54, 15684720.
    • (2005) DNA Cell Biol , vol.24 , Issue.1 , pp. 54-61
    • Brown, A.J.1    Jupe, S.2    Briscoe, C.P.3
  • 19
    • 0036266101 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
    • 10.1124/pr.54.2.265, 12037142
    • Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W, Pyne S, Tigyi G. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 2002, 54(2):265-269. 10.1124/pr.54.2.265, 12037142.
    • (2002) Pharmacol Rev , vol.54 , Issue.2 , pp. 265-269
    • Chun, J.1    Goetzl, E.J.2    Hla, T.3    Igarashi, Y.4    Lynch, K.R.5    Moolenaar, W.6    Pyne, S.7    Tigyi, G.8
  • 21
    • 3042856569 scopus 로고    scopus 로고
    • A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands
    • 10.1016/j.pharmthera.2004.04.005, 15246248
    • Kostenis E. A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands. Pharmacol Ther 2004, 102(3):243-257. 10.1016/j.pharmthera.2004.04.005, 15246248.
    • (2004) Pharmacol Ther , vol.102 , Issue.3 , pp. 243-257
    • Kostenis, E.1
  • 22
    • 34548319109 scopus 로고    scopus 로고
    • Chemogenomic approaches to drug discovery: similar receptors bind similar ligands
    • 10.1038/sj.bjp.0707308, 1978276, 17533415
    • Klabunde T. Chemogenomic approaches to drug discovery: similar receptors bind similar ligands. Br J Pharmacol 2007, 152(1):5-7. 10.1038/sj.bjp.0707308, 1978276, 17533415.
    • (2007) Br J Pharmacol , vol.152 , Issue.1 , pp. 5-7
    • Klabunde, T.1
  • 24
    • 0028844298 scopus 로고
    • The binding site of neuropeptide vasopressin V1a receptor. Evidence for a major localization within transmembrane regions
    • 10.1074/jbc.270.43.25771, 7592759
    • Mouillac B, Chini B, Balestre MN, Elands J, Trumpp-Kallmeyer S, Hoflack J, Hibert M, Jard S, Barberis C. The binding site of neuropeptide vasopressin V1a receptor. Evidence for a major localization within transmembrane regions. J Biol Chem 1995, 270(43):25771-25777. 10.1074/jbc.270.43.25771, 7592759.
    • (1995) J Biol Chem , vol.270 , Issue.43 , pp. 25771-25777
    • Mouillac, B.1    Chini, B.2    Balestre, M.N.3    Elands, J.4    Trumpp-Kallmeyer, S.5    Hoflack, J.6    Hibert, M.7    Jard, S.8    Barberis, C.9
  • 26
    • 43749109187 scopus 로고    scopus 로고
    • Crystal structure of squid rhodopsin
    • 10.1038/nature06925, 18480818
    • Murakami M, Kouyama T. Crystal structure of squid rhodopsin. Nature 2008, 453(7193):363-367. 10.1038/nature06925, 18480818.
    • (2008) Nature , vol.453 , Issue.7193 , pp. 363-367
    • Murakami, M.1    Kouyama, T.2
  • 27
    • 36448995359 scopus 로고    scopus 로고
    • High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
    • 10.1126/science.1150577, 2583103, 17962520
    • Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, et al. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007, 318(5854):1258-1265. 10.1126/science.1150577, 2583103, 17962520.
    • (2007) Science , vol.318 , Issue.5854 , pp. 1258-1265
    • Cherezov, V.1    Rosenbaum, D.M.2    Hanson, M.A.3    Rasmussen, S.G.4    Thian, F.S.5    Kobilka, T.S.6    Choi, H.J.7    Kuhn, P.8    Weis, W.I.9    Kobilka, B.K.10
  • 29
    • 56749103466 scopus 로고    scopus 로고
    • The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
    • 10.1126/science.1164772, 2586971, 18832607
    • Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC. The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 2008, 322(5905):1211-1217. 10.1126/science.1164772, 2586971, 18832607.
    • (2008) Science , vol.322 , Issue.5905 , pp. 1211-1217
    • Jaakola, V.P.1    Griffith, M.T.2    Hanson, M.A.3    Cherezov, V.4    Chien, E.Y.5    Lane, J.R.6    Ijzerman, A.P.7    Stevens, R.C.8
  • 30
    • 67649518035 scopus 로고    scopus 로고
    • Homology modeling in drug discovery: current trends and applications
    • 676-683
    • Cavasotto CN, Phatak SS. Homology modeling in drug discovery: current trends and applications. Drug Discov Today 2009, 14:(13-14):676-683.
    • (2009) Drug Discov Today , vol.14 , pp. 13-14
    • Cavasotto, C.N.1    Phatak, S.S.2
  • 32
    • 1542379652 scopus 로고    scopus 로고
    • Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions
    • 14660595
    • Madabushi S, Gross AK, Philippi A, Meng EC, Wensel TG, Lichtarge O. Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions. J Biol Chem 2004, 279(14660595):8126-8132.
    • (2004) J Biol Chem , vol.279 , pp. 8126-8132
    • Madabushi, S.1    Gross, A.K.2    Philippi, A.3    Meng, E.C.4    Wensel, T.G.5    Lichtarge, O.6
  • 33
    • 0042921467 scopus 로고    scopus 로고
    • Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein
    • 10.1002/prot.10489, 12910455
    • Oliveira L, Paiva PB, Paiva AC, Vriend G. Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein. Proteins 2003, 52(4):553-560. 10.1002/prot.10489, 12910455.
    • (2003) Proteins , vol.52 , Issue.4 , pp. 553-560
    • Oliveira, L.1    Paiva, P.B.2    Paiva, A.C.3    Vriend, G.4
  • 34
    • 33646813254 scopus 로고    scopus 로고
    • A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors
    • 10.1002/prot.20899, 16532452
    • Ye K, Lameijer EW, Beukers MW, Ijzerman AP. A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors. Proteins 2006, 63(4):1018-1030. 10.1002/prot.20899, 16532452.
    • (2006) Proteins , vol.63 , Issue.4 , pp. 1018-1030
    • Ye, K.1    Lameijer, E.W.2    Beukers, M.W.3    Ijzerman, A.P.4
  • 35
    • 33747754105 scopus 로고    scopus 로고
    • Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse
    • 10.1016/j.ygeno.2006.04.001, 16753280
    • Bjarnadottir TK, Gloriam DE, Hellstrand SH, Kristiansson H, Fredriksson R, Schioth HB. Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics 2006, 88(3):263-273. 10.1016/j.ygeno.2006.04.001, 16753280.
    • (2006) Genomics , vol.88 , Issue.3 , pp. 263-273
    • Bjarnadottir, T.K.1    Gloriam, D.E.2    Hellstrand, S.H.3    Kristiansson, H.4    Fredriksson, R.5    Schioth, H.B.6
  • 37
    • 37549049756 scopus 로고    scopus 로고
    • Multi-RELIEF: a method to recognize specificity determining residues from multiple sequence alignments using a Machine-Learning approach for feature weighting
    • 10.1093/bioinformatics/btm537, 18024975
    • Ye K, Feenstra KA, Heringa J, Ijzerman AP, Marchiori E. Multi-RELIEF: a method to recognize specificity determining residues from multiple sequence alignments using a Machine-Learning approach for feature weighting. Bioinformatics 2008, 24(1):18-25. 10.1093/bioinformatics/btm537, 18024975.
    • (2008) Bioinformatics , vol.24 , Issue.1 , pp. 18-25
    • Ye, K.1    Feenstra, K.A.2    Heringa, J.3    Ijzerman, A.P.4    Marchiori, E.5
  • 38
    • 0242362595 scopus 로고    scopus 로고
    • Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists
    • 10.1021/jm0300431, 14584936
    • Kim SK, Gao ZG, Van Rompaey P, Gross AS, Chen A, Van Calenbergh S, Jacobson KA. Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists. J Med Chem 2003, 46(23):4847-4859. 10.1021/jm0300431, 14584936.
    • (2003) J Med Chem , vol.46 , Issue.23 , pp. 4847-4859
    • Kim, S.K.1    Gao, Z.G.2    Van Rompaey, P.3    Gross, A.S.4    Chen, A.5    Van Calenbergh, S.6    Jacobson, K.A.7
  • 39
    • 0027371827 scopus 로고
    • Receptor activation of and signal generation by the lutropin/choriogonadotropin receptor. Cooperation of Asp397 of the receptor and alpha Lys91 of the hormone
    • Ji I, Zeng H, Ji TH. Receptor activation of and signal generation by the lutropin/choriogonadotropin receptor. Cooperation of Asp397 of the receptor and alpha Lys91 of the hormone. J Biol Chem 1993, 268(31):22971-22974.
    • (1993) J Biol Chem , vol.268 , Issue.31 , pp. 22971-22974
    • Ji, I.1    Zeng, H.2    Ji, T.H.3
  • 41
    • 75849153303 scopus 로고    scopus 로고
    • The Universal Protein Resource (UniProt) in 2010
    • Database
    • The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res 2010, (38 Database):D142-148.
    • (2010) Nucleic Acids Res , Issue.38
  • 43
    • 77957055780 scopus 로고
    • Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein coupled receptors
    • Ballesteros JA, W H. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein coupled receptors. Methods Neurosci 1995, 25:366-428.
    • (1995) Methods Neurosci , vol.25 , pp. 366-428
    • Ballesteros, J.A.1    W, H.2
  • 44
    • 0003818089 scopus 로고    scopus 로고
    • HMMER: Profile hidden Markov models for biological sequence analysis
    • HMMER: Profile hidden Markov models for biological sequence analysis. , http://hmmer.janelia.org
  • 47
    • 0037423211 scopus 로고    scopus 로고
    • The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling
    • 10.1074/jbc.M207420200, 12446735
    • Stitham J, Stojanovic A, Merenick BL, O'Hara KA, Hwa J. The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling. J Biol Chem 2003, 278(6):4250-4257. 10.1074/jbc.M207420200, 12446735.
    • (2003) J Biol Chem , vol.278 , Issue.6 , pp. 4250-4257
    • Stitham, J.1    Stojanovic, A.2    Merenick, B.L.3    O'Hara, K.A.4    Hwa, J.5
  • 48
    • 0035793604 scopus 로고    scopus 로고
    • An activation switch in the ligand binding pocket of the C5a receptor
    • 10.1074/jbc.M007748200, 11062244
    • Gerber BO, Meng EC, Dotsch V, Baranski TJ, Bourne HR. An activation switch in the ligand binding pocket of the C5a receptor. J Biol Chem 2001, 276(5):3394-3400. 10.1074/jbc.M007748200, 11062244.
    • (2001) J Biol Chem , vol.276 , Issue.5 , pp. 3394-3400
    • Gerber, B.O.1    Meng, E.C.2    Dotsch, V.3    Baranski, T.J.4    Bourne, H.R.5
  • 49
    • 38349184206 scopus 로고    scopus 로고
    • Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands
    • 10.1038/sj.bjp.0707567, 2219524, 17982473
    • Poso A, Huffman JW. Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands. Br J Pharmacol 2008, 153(2):335-346. 10.1038/sj.bjp.0707567, 2219524, 17982473.
    • (2008) Br J Pharmacol , vol.153 , Issue.2 , pp. 335-346
    • Poso, A.1    Huffman, J.W.2
  • 50
    • 18444386531 scopus 로고    scopus 로고
    • Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands
    • 10.2174/0929867053764617, 15892633
    • Raitio KH, Salo OM, Nevalainen T, Poso A, Jarvinen T. Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands. Curr Med Chem 2005, 12(10):1217-1237. 10.2174/0929867053764617, 15892633.
    • (2005) Curr Med Chem , vol.12 , Issue.10 , pp. 1217-1237
    • Raitio, K.H.1    Salo, O.M.2    Nevalainen, T.3    Poso, A.4    Jarvinen, T.5
  • 52
    • 35748937333 scopus 로고    scopus 로고
    • Identification of residues important for agonist recognition and activation in GPR40
    • 10.1074/jbc.M705077200, 17699519
    • Sum CS, Tikhonova IG, Neumann S, Engel S, Raaka BM, Costanzi S, Gershengorn MC. Identification of residues important for agonist recognition and activation in GPR40. J Biol Chem 2007, 282(40):29248-29255. 10.1074/jbc.M705077200, 17699519.
    • (2007) J Biol Chem , vol.282 , Issue.40 , pp. 29248-29255
    • Sum, C.S.1    Tikhonova, I.G.2    Neumann, S.3    Engel, S.4    Raaka, B.M.5    Costanzi, S.6    Gershengorn, M.C.7
  • 53
    • 0036923938 scopus 로고    scopus 로고
    • Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity
    • 10.1016/S0006-3495(02)75307-1, 1302382, 12496074
    • Paterlini MG. Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity. Biophys J 2002, 83(6):3012-3031. 10.1016/S0006-3495(02)75307-1, 1302382, 12496074.
    • (2002) Biophys J , vol.83 , Issue.6 , pp. 3012-3031
    • Paterlini, M.G.1
  • 54
    • 6044234752 scopus 로고    scopus 로고
    • Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling
    • 10.1021/jm049914c, 15481977
    • Costanzi S, Mamedova L, Gao ZG, Jacobson KA. Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling. J Med Chem 2004, 47(22):5393-5404. 10.1021/jm049914c, 15481977.
    • (2004) J Med Chem , vol.47 , Issue.22 , pp. 5393-5404
    • Costanzi, S.1    Mamedova, L.2    Gao, Z.G.3    Jacobson, K.A.4
  • 55
    • 34250792472 scopus 로고    scopus 로고
    • Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling
    • 417-426
    • Ivanov AA, Costanzi S, Jacobson KA. Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling. J Comput Aided Mol Des 2006, 20:(7-8):417-426.
    • (2006) J Comput Aided Mol Des , vol.20 , pp. 7-8
    • Ivanov, A.A.1    Costanzi, S.2    Jacobson, K.A.3
  • 56
    • 67650753759 scopus 로고    scopus 로고
    • Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design
    • 10.1021/jm900319e, 19537715
    • Gloriam DE, Foord SM, Blaney FE, Garland SL. Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design. J Med Chem 2009, 52(14):4429-4442. 10.1021/jm900319e, 19537715.
    • (2009) J Med Chem , vol.52 , Issue.14 , pp. 4429-4442
    • Gloriam, D.E.1    Foord, S.M.2    Blaney, F.E.3    Garland, S.L.4
  • 57
    • 41349088364 scopus 로고    scopus 로고
    • Managing bias in ROC curves
    • 10.1007/s10822-008-9181-z, 18256892
    • Clark RD, Webster-Clark DJ. Managing bias in ROC curves. J Comput Aided Mol Des 2008, 22(3-4):141-146. 10.1007/s10822-008-9181-z, 18256892.
    • (2008) J Comput Aided Mol Des , vol.22 , Issue.3-4 , pp. 141-146
    • Clark, R.D.1    Webster-Clark, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.