Three arginines in the GABAA receptor binding pocket have distinct roles in the formation and stability of agonist- versus antagonist-bound complexes

Molecular Pharmacology

Volumn 80, Issue 4, 2011, Pages 647-656

  Goldschen Ohm, Marcel P ^a   Wagner, David A ^a   Jones, Mathew V ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Marquette University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALANINE; ARGININE; CARBOXYL GROUP; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT;

ARTICLE; CELL STRAIN HEK293; CHANNEL GATING; CONDUCTANCE; DRUG RECEPTOR BINDING; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN STABILITY;

ARGININE; BINDING SITES; GABA AGONISTS; GABA ANTAGONISTS; HEK293 CELLS; HUMANS; MUTATION; PROTEIN BINDING; PROTEIN STABILITY; RECEPTORS, GABA-A;

EID: 80053209156     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.072033     Document Type: Article

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