Identification of amino acid residues within GABA(A) receptor β subunits that mediate both homomeric and heteromeric receptor expression

Journal of Neuroscience

Volumn 19, Issue 15, 1999, Pages 6360-6371

  Taylor, Pamela M ^a   Thomas, Philip ^b   Gorrie, George H ^a   Connolly, Christopher N ^a   Smart, Trevor G ^b   Moss, Stephen J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Assembly; Benzodiazepine; Cell surface; GABA receptor; Heteromeric; Homomeric

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; RECEPTOR SUBUNIT;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION;

EID: 0033178439     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-15-06360.1999     Document Type: Article

References (28)

1. A receptor subunits: α1β1 and α1β1γ2S subunits produce unique ion channels with dissimilar single-channel properties. J Neurosci 13:1429-1440.
2. Benke D, Fritschy JM, Trzeciak A, Bannwarth W, Mohler H (1994) Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant. J Biol Chem 269:27100-27107.
3. Chavez RA, Maloof J, Beeson D, Newsom-Davis J, Hall ZW (1992) Subunit folding and alpha delta heterodimer formation in the assembly of the nicotinic acetylcholine receptor. Comparison of the mouse and human alpha subunits. J Biol Chem 267:23028-23034.
4. Connolly CN, Krishek BJ, McDonald BJ, Smart TG, Moss SJ (1996a) Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors. J Biol Chem 271:89-96.
5. Connolly CN, Wooltorton JRA, Smart TG, Moss SJ (1996b) Subcellular localization of γ-aminobutyric acid type A receptors is determined by receptor β subunits. Proc Natl Acad Sci USA 93:9899-9904.
6. Davies PA, Hanna MC, Hales TG, Kirkness EF (1997) Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. Nature 385:820-823.
7. A receptor subtypes by Zn2+. Neuron 5:781-788.
8. Evan GI, Lewis G, Ramsey G, Bishop JM (1985) Isolation of monoclonal antibodies specific for human c-myc proto oncogene product. Mol Cell Biol 5:3610-3616.
9. A receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts. J Neurosci 17:6587-6596.
10. Gu Y, Camacho P, Gardner P, Hall ZW (1991) Identification of two amino acid residues in the epsilon subunit that promote mammalian muscle acetylcholine receptor assembly in COS cells. Neuron 1991 6:879-887.
11. Hackam AS, Wang TL, Guggino WB, Cutting GR (1997) The N-terminal domain of human GABA receptor p1 subunits contains signals for homooligomeric and heterooligomeric interaction. J Biol Chem 272:13750-13757.
12. Hammond C, Helenius A (1995) Quality control in the secretory pathway. Curr Opin Cell Biol 7:670-529.
13. A receptor subunit in tissues of the reproductive system. J Biol Chem 272:15346-15350.
14. Heim R, Cubitt AB, Tsien RY (1995) Improved green fluorescent proteins. Nature 373:663-664.
15. Kofuji P, Wang JB, Moss SJ, Huganir RL, Burt DR (1991) Generation of two forms of the gamma-aminobutyric acid A receptor gamma 2-subunit in mice by alternative splicing. J Neurochem 56:713-715.
16. Kreienkamp HJ, Maeda RK, Sine SM, Taylor P (1995) Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor. Neuron 14:635-644.
17. Kuhse J, Laube B, Magalei D, Betz H (1993) Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry. Neuron 1993 6:1049-1056.
18. Kunkel TA (1985) Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci USA 82:488-492.
19. A receptor subunit mRNAs in the rat brain II. Olfactory bulb and cerebellum. J Neurosci 12:4151-4172.
20. A receptor channels. Annu Rev Neurosci 17:569-602.
21. A receptor βsubunits determine regulation by cAMP-dependent protein kinase. Nature Neurosci 1:23-28.
22. A receptor research. Synapse 21:189-274.
23. A receptors on channel function. Neuron 5:703-711.
24. A receptor subtype. J Neurosci 17:2728-2737.
25. Whiting P, McKernan RM, Iversen LL (1990) Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site. Proc Natl Acad Sci USA 87:9966-9970.
26. A receptor complex: dependence on the second transmembrane domain of β subunits. J Physiol (Lond) 505.3:633-640.
27. A receptor β subunit heterogeneity: functional expression of cloned cDNAs. EMBO J 8:1665-1670.
28. g1 receptors containing one, two or three different subunits. Eur J Pharmacol 301:207-214.