메뉴 건너뛰기




Volumn 3, Issue 3, 2011, Pages 3029-3054

Dual targeting of the insulin-like growth factor and collateral pathways in cancer: Combating drug resistance

Author keywords

Combination therapy; Drug resistance; Ewing sarcoma; IGF 1R; Insulin like growth factor

Indexed keywords

ANTINEOPLASTIC AGENT; CETUXIMAB; CISPLATIN; CIXUTUMUMAB; FIGITUMUMAB; GEFITINIB; GEMCITABINE; GSK 1838705A; IMATINIB; INSULIN RECEPTOR; LIGAND; LINSITINIB; MEDI 573; MONOCLONAL ANTIBODY; NVP AEW 541; PEMETREXED; PERTUZUMAB; R 1507; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C RECEPTOR; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 80053203958     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3033029     Document Type: Article
Times cited : (25)

References (157)
  • 1
    • 0346206633 scopus 로고
    • A hormonally controlled serum factor which stimulatessulfate incorporation by cartilage in vitro
    • Salmon, W.D., Jr.; Daughaday, W.H. A hormonally controlled serum factor which stimulatessulfate incorporation by cartilage in vitro. J. Lab. Clin. Med. 1957, 49, 825-836.
    • (1957) J. Lab. Clin. Med , vol.49 , pp. 825-836
    • Salmon Jr., W.D.1    Daughaday, W.H.2
  • 2
    • 72449159103 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor type 1 receptor in cancer therapy
    • Atzori, F.; Traina, T.A.; Ionta, M.T.; Massidda, B. Targeting insulin-like growth factor type 1 receptor in cancer therapy. Target Oncol. 2009, 4, 255-266.
    • (2009) Target Oncol , vol.4 , pp. 255-266
    • Atzori, F.1    Traina, T.A.2    Ionta, M.T.3    Massidda, B.4
  • 3
    • 3042775027 scopus 로고    scopus 로고
    • The insulin like growth factor-1 receptor (IGF-1R) as a drug target: Novel approaches to cancer therapy
    • Bahr, C.; Groner, B. The insulin like growth factor-1 receptor (IGF-1R) as a drug target: Novel approaches to cancer therapy. Growth Horm. IGF Res. 2004, 14, 287-295.
    • (2004) Growth Horm. IGF Res , vol.14 , pp. 287-295
    • Bahr, C.1    Groner, B.2
  • 4
    • 25144496041 scopus 로고    scopus 로고
    • The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function
    • Bahr, C.; Groner, B. The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function. Growth Factors 2005, 23, 1-14.
    • (2005) Growth Factors , vol.23 , pp. 1-14
    • Bahr, C.1    Groner, B.2
  • 5
    • 70349462997 scopus 로고    scopus 로고
    • The rationale and development of therapeutic insulin-like growth factor axis inhibition for lung and other cancers
    • Camidge, D.R.; Dziadziuszko, R.; Hirsch, F.R. The rationale and development of therapeutic insulin-like growth factor axis inhibition for lung and other cancers. Clin. Lung Cancer 2009, 10, 262-272.
    • (2009) Clin. Lung Cancer , vol.10 , pp. 262-272
    • Camidge, D.R.1    Dziadziuszko, R.2    Hirsch, F.R.3
  • 6
    • 79951860072 scopus 로고    scopus 로고
    • Small is beautiful: Insulin-like growth factors and their role in growth, development, and cancer
    • Maki, R.G. Small is beautiful: Insulin-like growth factors and their role in growth, development, and cancer. J. Clin. Oncol. 2010, 28, 4985-4995.
    • (2010) J. Clin. Oncol , vol.28 , pp. 4985-4995
    • Maki, R.G.1
  • 7
    • 77956230328 scopus 로고    scopus 로고
    • Defining the pathway to insulin-like growth factor system targeting in cancer
    • Rosenzweig, S.A.; Atreya, H.S. Defining the pathway to insulin-like growth factor system targeting in cancer. Biochem. Pharmacol. 2010, 80, 1115-1124.
    • (2010) Biochem. Pharmacol , vol.80 , pp. 1115-1124
    • Rosenzweig, S.A.1    Atreya, H.S.2
  • 8
    • 0024403208 scopus 로고
    • Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man
    • Moller, D.E.; Yokota, A.; Caro, J.F.; Flier, J.S. Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol. Endocrinol. 1989, 3, 1263-1269.
    • (1989) Mol. Endocrinol , vol.3 , pp. 1263-1269
    • Moller, D.E.1    Yokota, A.2    Caro, J.F.3    Flier, J.S.4
  • 9
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich, A.; Gray, A.; Tam, A.W.; Yang-Feng, T.; Tsubokawa, M.; Collins, C.; Henzel, W.; Le Bon, T.; Kathuria, S.; Chen, E. et al. Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 1986, 5, 2503-2512.
    • (1986) EMBO J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3    Yang-Feng, T.4    Tsubokawa, M.5    Collins, C.6    Henzel, W.7    le Bon, T.8    Kathuria, S.9    Chen, E.10
  • 10
    • 0029838475 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target
    • Scotlandi, K.; Benini, S.; Sarti, M.; Serra, M.; Lollini, P.L.; Maurici, D.; Picci, P.; Manara, M.C.; Baldini, N. Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target. Cancer Res. 1996, 56, 4570-4574.
    • (1996) Cancer Res , vol.56 , pp. 4570-4574
    • Scotlandi, K.1    Benini, S.2    Sarti, M.3    Serra, M.4    Lollini, P.L.5    Maurici, D.6    Picci, P.7    Manara, M.C.8    Baldini, N.9
  • 11
    • 4444266113 scopus 로고    scopus 로고
    • Targeting the IGF-1 receptor: From rags to riches
    • Baserga, R. Targeting the IGF-1 receptor: From rags to riches. Eur. J. Cancer 2004, 40, 2013-2015.
    • (2004) Eur. J. Cancer , vol.40 , pp. 2013-2015
    • Baserga, R.1
  • 12
    • 0028582185 scopus 로고
    • Crystal structure of the tyrosine kinase domain of the human insulin receptor
    • Hubbard, S.R.; Wei, L.; Ellis, L.; Hendrickson, W.A. Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 1994, 372, 746-754.
    • (1994) Nature , vol.372 , pp. 746-754
    • Hubbard, S.R.1    Wei, L.2    Ellis, L.3    Hendrickson, W.A.4
  • 13
    • 0035185571 scopus 로고    scopus 로고
    • Structure and autoregulation of the insulinlike growth factor 1 receptor kinase
    • Favelyukis, S.; Till, J.H.; Hubbard, S.R.; Miller, W.T. Structure and autoregulation of the insulinlike growth factor 1 receptor kinase. Nat. Struct. Biol. 2001, 8, 1058-1063.
    • (2001) Nat. Struct. Biol , vol.8 , pp. 1058-1063
    • Favelyukis, S.1    Till, J.H.2    Hubbard, S.R.3    Miller, W.T.4
  • 14
    • 0034793734 scopus 로고    scopus 로고
    • Crystal structure of bisphosphorylated IGF-1 receptor kinase: Insight into domain movements upon kinase activation
    • Pautsch, A.; Zoephel, A.; Ahorn, H.; Spevak, W.; Hauptmann, R.; Nar, H. Crystal structure of bisphosphorylated IGF-1 receptor kinase: Insight into domain movements upon kinase activation. Structure 2001, 9, 955-965.
    • (2001) Structure , vol.9 , pp. 955-965
    • Pautsch, A.1    Zoephel, A.2    Ahorn, H.3    Spevak, W.4    Hauptmann, R.5    Nar, H.6
  • 15
    • 43949125837 scopus 로고    scopus 로고
    • Quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R
    • Kaushansky, A.; Gordus, A.; Chang, B.; Rush, J.; MacBeath, G. A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R. Mol. Biosyst. 2008, 4, 643-653.
    • (2008) Mol. Biosyst , vol.4 , pp. 643-653
    • Kaushansky, A.1    Gordus, A.2    Chang, B.3    Rush, J.4    Macbeath, G.A.5
  • 16
    • 0028838012 scopus 로고
    • Dimerization of cell surface receptors in signal transduction
    • Heldin, C.H. Dimerization of cell surface receptors in signal transduction. Cell 1995, 80, 213-223.
    • (1995) Cell , vol.80 , pp. 213-223
    • Heldin, C.H.1
  • 17
    • 0242594016 scopus 로고    scopus 로고
    • The IGF-1 receptor in cancer biology
    • Baserga, R.; Peruzzi, F.; Reiss, K. The IGF-1 receptor in cancer biology. Int. J. Cancer 2003, 107, 873-877.
    • (2003) Int. J. Cancer , vol.107 , pp. 873-877
    • Baserga, R.1    Peruzzi, F.2    Reiss, K.3
  • 19
    • 0035719947 scopus 로고    scopus 로고
    • Distinct and overlapping functions of insulin and IGF-I receptors
    • Nakae, J.; Kido, Y.; Accili, D. Distinct and overlapping functions of insulin and IGF-I receptors. Endocr. Rev. 2001, 22, 818-835.
    • (2001) Endocr. Rev , vol.22 , pp. 818-835
    • Nakae, J.1    Kido, Y.2    Accili, D.3
  • 20
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak, M. Insulin and insulin-like growth factor signalling in neoplasia. Nat. Rev. Cancer. 2008, 8, 915-928.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 21
    • 0028068826 scopus 로고
    • The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer
    • Almeida, A.; Muleris, M.; Dutrillaux, B.; Malfoy, B. The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer. Genes Chromosomes Cancer 1994, 11, 63-65.
    • (1994) Genes Chromosomes Cancer , vol.11 , pp. 63-65
    • Almeida, A.1    Muleris, M.2    Dutrillaux, B.3    Malfoy, B.4
  • 23
    • 0033991993 scopus 로고    scopus 로고
    • DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma
    • Armengol, G.; Knuutila, S.; Lluis, F.; Capella, G.; Miro, R.; Caballin, M.R. DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma. Cancer Genet. Cytogenet. 2000, 116, 133-141.
    • (2000) Cancer Genet. Cytogenet , vol.116 , pp. 133-141
    • Armengol, G.1    Knuutila, S.2    Lluis, F.3    Capella, G.4    Miro, R.5    Caballin, M.R.6
  • 25
    • 0035857042 scopus 로고    scopus 로고
    • Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2
    • Nair, P.N.; De Armond, D.T.; Adamo, M.L.; Strodel, W.E.; Freeman, J.W. Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2. Oncogene 2001, 20, 8203-8214.
    • (2001) Oncogene , vol.20 , pp. 8203-8214
    • Nair, P.N.1    de Armond, D.T.2    Adamo, M.L.3    Strodel, W.E.4    Freeman, J.W.5
  • 26
    • 0347626094 scopus 로고    scopus 로고
    • Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: Therapeutic prospects
    • Benini, S.; Manara, M.C.; Cerisano, V.; Perdichizzi, S.; Strammiello, R.; Serra, M.; Picci, P.; Scotlandi, K. Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects. Int. J. Cancer 2004, 108, 358-366.
    • (2004) Int. J. Cancer , vol.108 , pp. 358-366
    • Benini, S.1    Manara, M.C.2    Cerisano, V.3    Perdichizzi, S.4    Strammiello, R.5    Serra, M.6    Picci, P.7    Scotlandi, K.8
  • 27
    • 35148837581 scopus 로고    scopus 로고
    • Mechanisms of disease: Signaling of the insulin-like growth factor 1 receptor pathway--therapeutic perspectives in cancer
    • Tao, Y.; Pinzi, V.; Bourhis, J.; Deutsch, E. Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway--therapeutic perspectives in cancer. Nat. Clin. Pract. Oncol. 2007, 4, 591-602.
    • (2007) Nat. Clin. Pract. Oncol , vol.4 , pp. 591-602
    • Tao, Y.1    Pinzi, V.2    Bourhis, J.3    Deutsch, E.4
  • 28
    • 34548427415 scopus 로고    scopus 로고
    • The biology behind mTOR inhibition in sarcoma
    • Wan, X.; Helman, L.J. The biology behind mTOR inhibition in sarcoma. Oncologist 2007, 12, 1007-1018.
    • (2007) Oncologist , vol.12 , pp. 1007-1018
    • Wan, X.1    Helman, L.J.2
  • 29
    • 54949144410 scopus 로고    scopus 로고
    • Mtor inhibitors in the treatment of cancer
    • Fasolo, A.; Sessa, C. mTOR inhibitors in the treatment of cancer. Expert. Opin. Investig. Drugs 2008, 17, 1717-1734.
    • (2008) Expert. Opin. Investig. Drugs , vol.17 , pp. 1717-1734
    • Fasolo, A.1    Sessa, C.2
  • 30
    • 0036828097 scopus 로고    scopus 로고
    • Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: Therapeutic implications
    • Chang, Q.; Li, Y.; White, M.F.; Fletcher, J.A.; Xiao, S. Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: Therapeutic implications. Cancer Res. 2002, 62, 6035-6038.
    • (2002) Cancer Res , vol.62 , pp. 6035-6038
    • Chang, Q.1    Li, Y.2    White, M.F.3    Fletcher, J.A.4    Xiao, S.5
  • 31
    • 77949904455 scopus 로고    scopus 로고
    • Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death
    • Alberobello, A.T.; D'Esposito, V.; Marasco, D.; Doti, N.; Ruvo, M.; Bianco, R.; Tortora, G.; Esposito, I.; Fiory, F.; Miele, C.; Beguinot, F.; Formisano, P. Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death. J. Biol. Chem. 2010, 285, 6563-6572.
    • (2010) J. Biol. Chem , vol.285 , pp. 6563-6572
    • Alberobello, A.T.1    D'esposito, V.2    Marasco, D.3    Doti, N.4    Ruvo, M.5    Bianco, R.6    Tortora, G.7    Esposito, I.8    Fiory, F.9    Miele, C.10    Beguinot, F.11    Formisano, P.12
  • 32
    • 0028363159 scopus 로고
    • Diverse roles of insulin-like growth factors in pediatric solid tumors
    • Hirschfeld, S.; Helman, L. Diverse roles of insulin-like growth factors in pediatric solid tumors. In Vivo 1994, 8, 81-90.
    • (1994) In Vivo , vol.8 , pp. 81-90
    • Hirschfeld, S.1    Helman, L.2
  • 33
    • 69149097240 scopus 로고    scopus 로고
    • Targeting IGF-1R in the treatment of sarcomas: Past, present and future
    • Kim, S.Y.; Wan, X.; Helman, L.J. Targeting IGF-1R in the treatment of sarcomas: Past, present and future. Bull. Cancer 2009, 96, E52-60.
    • (2009) Bull. Cancer , vol.96
    • Kim, S.Y.1    Wan, X.2    Helman, L.J.3
  • 34
    • 0033012406 scopus 로고    scopus 로고
    • Expression of the insulin-like growth factor 1 receptor (IGF-1R) in breast cancer cells: Evidence for a regulatory role of dolichyl phosphate in the transition from an intracellular to an extracellular IGF-1 pathway
    • Dricu, A.; Kanter, L.; Wang, M.; Nilsson, G.; Hjertman, M.; Wejde, J.; Larsson, O. Expression of the insulin-like growth factor 1 receptor (IGF-1R) in breast cancer cells: evidence for a regulatory role of dolichyl phosphate in the transition from an intracellular to an extracellular IGF-1 pathway. Glycobiology 1999, 9, 571-579.
    • (1999) Glycobiology , vol.9 , pp. 571-579
    • Dricu, A.1    Kanter, L.2    Wang, M.3    Nilsson, G.4    Hjertman, M.5    Wejde, J.6    Larsson, O.7
  • 35
    • 0033113448 scopus 로고    scopus 로고
    • Insulin-like growth factors and cancer
    • Yu, H.; Berkel, H. Insulin-like growth factors and cancer. J. La. State. Med. Soc. 1999, 151, 218-223.
    • (1999) J. La. State. Med. Soc , vol.151 , pp. 218-223
    • Yu, H.1    Berkel, H.2
  • 36
    • 0344406727 scopus 로고    scopus 로고
    • Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells
    • Moore, M.G.; Wetterau, L.A.; Francis, M.J.; Peehl, D.M.; Cohen, P. Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells. Int. J. Cancer. 2003, 105, 14-19.
    • (2003) Int. J. Cancer , vol.105 , pp. 14-19
    • Moore, M.G.1    Wetterau, L.A.2    Francis, M.J.3    Peehl, D.M.4    Cohen, P.5
  • 37
    • 38049110518 scopus 로고    scopus 로고
    • Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells
    • Ma, Z.; Dong, A.; Kong, M.; Qian, J. Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells. Cell Mol. Biol. Lett. 2007, 12, 556-572.
    • (2007) Cell Mol. Biol. Lett , vol.12 , pp. 556-572
    • Ma, Z.1    Dong, A.2    Kong, M.3    Qian, J.4
  • 38
    • 33847198926 scopus 로고    scopus 로고
    • Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report
    • Shevah, O.; Laron, Z. Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report. Growth Horm. IGF Res. 2007, 17, 54-57.
    • (2007) Growth Horm. IGF Res , vol.17 , pp. 54-57
    • Shevah, O.1    Laron, Z.2
  • 39
    • 79953221503 scopus 로고    scopus 로고
    • Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies
    • Steuerman, R.; Shevah, O.; Laron, Z. Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. Eur. J. Endocrinol. 2011, 164, 485-489.
    • (2011) Eur. J. Endocrinol , vol.164 , pp. 485-489
    • Steuerman, R.1    Shevah, O.2    Laron, Z.3
  • 40
    • 69049108757 scopus 로고    scopus 로고
    • Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach
    • Li, R.; Pourpak, A.; Morris, S.W. Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J. Med. Chem. 2009, 52, 4981-5004.
    • (2009) J. Med. Chem , vol.52 , pp. 4981-5004
    • Li, R.1    Pourpak, A.2    Morris, S.W.3
  • 41
    • 0842303519 scopus 로고    scopus 로고
    • Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells
    • Frasca, F.; Pandini, G.; Vigneri, R.; Goldfine, I.D. Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells. Breast Dis. 2003, 17, 73-89.
    • (2003) Breast Dis , vol.17 , pp. 73-89
    • Frasca, F.1    Pandini, G.2    Vigneri, R.3    Goldfine, I.D.4
  • 44
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu, Y.; Zi, X.; Zhao, Y.; Mascarenhas, D.; Pollak, M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J. Natl. Cancer Inst. 2001, 93, 1852-1857.
    • (2001) J. Natl. Cancer Inst , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3    Mascarenhas, D.4    Pollak, M.5
  • 45
    • 28244432561 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    • Nahta, R.; Yuan, L.X.; Zhang, B.; Kobayashi, R.; Esteva, F.J. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res. 2005, 65, 11118-11128.
    • (2005) Cancer Res , vol.65 , pp. 11118-11128
    • Nahta, R.1    Yuan, L.X.2    Zhang, B.3    Kobayashi, R.4    Esteva, F.J.5
  • 46
    • 40449120461 scopus 로고    scopus 로고
    • Co-targeting insulin-like growth factor I receptor and HER2: Dramatic effects of HER2 inhibitors on nonoverexpressing breast cancer
    • Chakraborty, A.K.; Liang, K.; DiGiovanna, M.P. Co-targeting insulin-like growth factor I receptor and HER2: Dramatic effects of HER2 inhibitors on nonoverexpressing breast cancer. Cancer Res. 2008, 68, 1538-1545.
    • (2008) Cancer Res , vol.68 , pp. 1538-1545
    • Chakraborty, A.K.1    Liang, K.2    Digiovanna, M.P.3
  • 47
    • 78650372147 scopus 로고    scopus 로고
    • Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells
    • Browne, B.C.; Crown, J.; Venkatesan, N.; Duffy, M.J.; Clynes, M.; Slamon, D.; O'Donovan, N. Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells. Ann. Oncol. 2011, 22, 68-73.
    • (2011) Ann. Oncol , vol.22 , pp. 68-73
    • Browne, B.C.1    Crown, J.2    Venkatesan, N.3    Duffy, M.J.4    Clynes, M.5    Slamon, D.6    O'Donovan, N.7
  • 48
    • 70349148288 scopus 로고    scopus 로고
    • Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: Implications for cancer therapy
    • van der Veeken, J.; Oliveira, S.; Schiffelers, R.M.; Storm, G.; van Bergen En Henegouwen, P.M.; Roovers, R.C. Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: implications for cancer therapy. Curr. Cancer Drug Targets 2009, 9, 748-760.
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 748-760
    • van der Veeken, J.1    Oliveira, S.2    Schiffelers, R.M.3    Storm, G.4    van Bergen, E.H.P.M.5    Roovers, R.C.6
  • 50
    • 17144416483 scopus 로고    scopus 로고
    • Vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgendependent and androgen-independent xenograft human prostate tumors
    • Wu, J.D.; Odman, A.; Higgins, L.M.; Haugk, K.; Vessella, R.; Ludwig, D.L.; Plymate, S.R. In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgendependent and androgen-independent xenograft human prostate tumors. Clin. Cancer Res. 2005, 11, 3065-3074.
    • (2005) Clin. Cancer Res , vol.11 , pp. 3065-3074
    • Wu, J.D.1    Odman, A.2    Higgins, L.M.3    Haugk, K.4    Vessella, R.5    Ludwig, D.L.6    Plymate, S.R.7
  • 51
    • 0035878820 scopus 로고    scopus 로고
    • Androgen blocks apoptosis of hormonedependent prostate cancer cells
    • Kimura, K.; Markowski, M.; Bowen, C.; Gelmann, E.P. Androgen blocks apoptosis of hormonedependent prostate cancer cells. Cancer Res. 2001, 61, 5611-5618.
    • (2001) Cancer Res , vol.61 , pp. 5611-5618
    • Kimura, K.1    Markowski, M.2    Bowen, C.3    Gelmann, E.P.4
  • 52
    • 33750571170 scopus 로고    scopus 로고
    • Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
    • Morgillo, F.; Woo, J.K.; Kim, E.S.; Hong, W.K.; Lee, H.Y. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res. 2006, 66, 10100-10111.
    • (2006) Cancer Res , vol.66 , pp. 10100-10111
    • Morgillo, F.1    Woo, J.K.2    Kim, E.S.3    Hong, W.K.4    Lee, H.Y.5
  • 53
    • 10344247119 scopus 로고    scopus 로고
    • A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts
    • Goetsch, L.; Gonzalez, A.; Leger, O.; Beck, A.; Pauwels, P.J.; Haeuw, J.F.; Corvaia, N. A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int. J. Cancer 2005, 113, 316-328.
    • (2005) Int. J. Cancer , vol.113 , pp. 316-328
    • Goetsch, L.1    Gonzalez, A.2    Leger, O.3    Beck, A.4    Pauwels, P.J.5    Haeuw, J.F.6    Corvaia, N.7
  • 56
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • Bardelli, A.; Siena, S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J. Clin. Oncol. 2010, 28, 1254-1261.
    • (2010) J. Clin. Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 58
    • 33750139113 scopus 로고    scopus 로고
    • Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer
    • Hopfner, M.; Sutter, A.P.; Huether, A.; Baradari, V.; Scherubl, H. Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. World J. Gastroenterol. 2006, 12, 5635-5643.
    • (2006) World J. Gastroenterol , vol.12 , pp. 5635-5643
    • Hopfner, M.1    Sutter, A.P.2    Huether, A.3    Baradari, V.4    Scherubl, H.5
  • 59
    • 41249093600 scopus 로고    scopus 로고
    • Role of insulin-like growth factor-1R system in colorectal carcinogenesis
    • Donovan, E.A.; Kummar, S. Role of insulin-like growth factor-1R system in colorectal carcinogenesis. Crit. Rev. Oncol. Hematol. 2008, 66, 91-98.
    • (2008) Crit. Rev. Oncol. Hematol , vol.66 , pp. 91-98
    • Donovan, E.A.1    Kummar, S.2
  • 60
    • 0033531765 scopus 로고    scopus 로고
    • Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    • Ma, J.; Pollak, M.N.; Giovannucci, E.; Chan, J.M.; Tao, Y.; Hennekens, C.H.; Stampfer, M.J. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J. Natl. Cancer Inst. 1999, 91, 620-625.
    • (1999) J. Natl. Cancer Inst , vol.91 , pp. 620-625
    • Ma, J.1    Pollak, M.N.2    Giovannucci, E.3    Chan, J.M.4    Tao, Y.5    Hennekens, C.H.6    Stampfer, M.J.7
  • 61
    • 0003256124 scopus 로고    scopus 로고
    • RESPONSE: More about: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF- binding protein-3
    • Ma, J.; Stampfer, M.; Pollak, M. RESPONSE: More about: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF- binding protein-3. J. Natl. Cancer Inst. 2000, 92, 1949.
    • (2000) J. Natl. Cancer Inst , vol.92 , pp. 1949
    • Ma, J.1    Stampfer, M.2    Pollak, M.3
  • 63
    • 0037092971 scopus 로고    scopus 로고
    • Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
    • Hellawell, G.O.; Turner, G.D.; Davies, D.R.; Poulsom, R.; Brewster, S.F.; Macaulay, V.M. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res. 2002, 62, 2942-2950.
    • (2002) Cancer Res , vol.62 , pp. 2942-2950
    • Hellawell, G.O.1    Turner, G.D.2    Davies, D.R.3    Poulsom, R.4    Brewster, S.F.5    Macaulay, V.M.6
  • 64
    • 0242403449 scopus 로고    scopus 로고
    • Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma
    • Hakam, A.; Fang, Q.; Karl, R.; Coppola, D. Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Dig. Dis. Sci. 2003, 48, 1972-1978.
    • (2003) Dig. Dis. Sci , vol.48 , pp. 1972-1978
    • Hakam, A.1    Fang, Q.2    Karl, R.3    Coppola, D.4
  • 65
    • 0028793568 scopus 로고
    • Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor
    • Freeman, J.W.; Mattingly, C.A.; Strodel, W.E. Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor. J. Cell. Physiol. 1995, 165, 155-163.
    • (1995) J. Cell. Physiol , vol.165 , pp. 155-163
    • Freeman, J.W.1    Mattingly, C.A.2    Strodel, W.E.3
  • 66
    • 78651355589 scopus 로고    scopus 로고
    • The complexities of obesity and diabetes with the development and progression of pancreatic cancer
    • Bao, B.; Wang, Z.; Li, Y.; Kong, D.; Ali, S.; Banerjee, S.; Ahmad, A.; Sarkar, F.H. The complexities of obesity and diabetes with the development and progression of pancreatic cancer. Biochim. Biophys. Acta 2011, 1815, 135-146.
    • (2011) Biochim. Biophys. Acta , vol.1815 , pp. 135-146
    • Bao, B.1    Wang, Z.2    Li, Y.3    Kong, D.4    Ali, S.5    Banerjee, S.6    Ahmad, A.7    Sarkar, F.H.8
  • 68
    • 0028997487 scopus 로고
    • Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
    • Bergmann, U.; Funatomi, H.; Yokoyama, M.; Beger, H.G.; Korc, M. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res. 1995, 55, 2007-2011.
    • (1995) Cancer Res , vol.55 , pp. 2007-2011
    • Bergmann, U.1    Funatomi, H.2    Yokoyama, M.3    Beger, H.G.4    Korc, M.5
  • 69
    • 0042926509 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer
    • Stoeltzing, O.; Liu, W.; Reinmuth, N.; Fan, F.; Parikh, A.A.; Bucana, C.D.; Evans, D.B.; Semenza, G.L.; Ellis, L.M. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am. J. Pathol. 2003, 163, 1001-1011.
    • (2003) Am. J. Pathol , vol.163 , pp. 1001-1011
    • Stoeltzing, O.1    Liu, W.2    Reinmuth, N.3    Fan, F.4    Parikh, A.A.5    Bucana, C.D.6    Evans, D.B.7    Semenza, G.L.8    Ellis, L.M.9
  • 72
    • 58149107984 scopus 로고    scopus 로고
    • The insulin-like growth factor pathway in lung cancer
    • Dziadziuszko, R.; Camidge, D.R.; Hirsch, F.R. The insulin-like growth factor pathway in lung cancer. J. Thorac. Oncol. 2008, 3, 815-818.
    • (2008) J. Thorac. Oncol , vol.3 , pp. 815-818
    • Dziadziuszko, R.1    Camidge, D.R.2    Hirsch, F.R.3
  • 73
    • 0033585421 scopus 로고    scopus 로고
    • Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis
    • Yu, H.; Spitz, M.R.; Mistry, J.; Gu, J.; Hong, W.K.; Wu, X. Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis. J. Natl. Cancer Inst. 1999, 91, 151-156.
    • (1999) J. Natl. Cancer Inst , vol.91 , pp. 151-156
    • Yu, H.1    Spitz, M.R.2    Mistry, J.3    Gu, J.4    Hong, W.K.5    Wu, X.6
  • 74
    • 0037094239 scopus 로고    scopus 로고
    • Insulinlike growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China
    • London, S.J.; Yuan, J.M.; Travlos, G.S.; Gao, Y.T.; Wilson, R.E.; Ross, R.K.; Yu, M.C. Insulinlike growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China. J. Natl. Cancer Inst. 2002, 94, 749-754.
    • (2002) J. Natl. Cancer Inst , vol.94 , pp. 749-754
    • London, S.J.1    Yuan, J.M.2    Travlos, G.S.3    Gao, Y.T.4    Wilson, R.E.5    Ross, R.K.6    Yu, M.C.7
  • 75
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and metaregression analysis
    • Renehan, A.G.; Zwahlen, M.; Minder, C.; O'Dwyer, S.T.; Shalet, S.M.; Egger, M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and metaregression analysis. Lancet 2004, 363, 1346-1353.
    • (2004) Lancet , vol.363 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3    O'Dwyer, S.T.4    Shalet, S.M.5    Egger, M.6
  • 76
    • 70349443573 scopus 로고    scopus 로고
    • Development of the monoclonal antibody figitumumab, targeting the insulin-like growth factor-1 receptor, for the treatment of patients with non-small-cell lung cancer
    • Gualberto, A.; Karp, D.D. Development of the monoclonal antibody figitumumab, targeting the insulin-like growth factor-1 receptor, for the treatment of patients with non-small-cell lung cancer. Clin. Lung Cancer 2009, 10, 273-280.
    • (2009) Clin. Lung Cancer , vol.10 , pp. 273-280
    • Gualberto, A.1    Karp, D.D.2
  • 77
    • 66349091290 scopus 로고    scopus 로고
    • Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
    • Karp, D.D.; Paz-Ares, L.G.; Novello, S.; Haluska, P.; Garland, L.; Cardenal, F.; Blakely, L.J.; Eisenberg, P.D.; Langer, C.J.; Blumenschein, G., Jr.; Johnson, F.M.; Green, S.; Gualberto, A. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J. Clin. Oncol. 2009, 27, 2516-2522.
    • (2009) J. Clin. Oncol , vol.27 , pp. 2516-2522
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3    Haluska, P.4    Garland, L.5    Cardenal, F.6    Blakely, L.J.7    Eisenberg, P.D.8    Langer, C.J.9    Blumenschein Jr., G.10    Johnson, F.M.11    Green, S.12    Gualberto, A.13
  • 78
    • 80052437059 scopus 로고    scopus 로고
    • New molecular targeted therapies for advanced nonsmall-cell lung cancer
    • Méndez, M.; Custodio, A.; Provencio, M. New molecular targeted therapies for advanced nonsmall-cell lung cancer. J. Thoracic Dis. 2011, 3, 30-56.
    • (2011) J. Thoracic Dis , vol.3 , pp. 30-56
    • Méndez, M.1    Custodio, A.2    Provencio, M.3
  • 80
    • 0030695913 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
    • Toretsky, J.A.; Kalebic, T.; Blakesley, V.; LeRoith, D.; Helman, L.J. The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts. J. Biol. Chem. 1997, 272, 30822-30827.
    • (1997) J. Biol. Chem , vol.272 , pp. 30822-30827
    • Toretsky, J.A.1    Kalebic, T.2    Blakesley, V.3    Leroith, D.4    Helman, L.J.5
  • 82
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur, A.; Tirode, F.; Cohen, P.; Delattre, O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol. Cell Biol. 2004, 24, 7275-7283.
    • (2004) Mol. Cell Biol , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 85
    • 43349088787 scopus 로고    scopus 로고
    • Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer
    • Yuen, J.S.; Macaulay, V.M. Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer. Expert. Opin. Ther. Targets 2008, 12, 589-603.
    • (2008) Expert. Opin. Ther. Targets , vol.12 , pp. 589-603
    • Yuen, J.S.1    Macaulay, V.M.2
  • 86
    • 78049495856 scopus 로고    scopus 로고
    • Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification
    • Janeway, K.A.; Zhu, M.J.; Barretina, J.; Perez-Atayde, A.; Demetri, G.D.; Fletcher, J.A. Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification. Int. J. Cancer 2010, 127, 2718-2722.
    • (2010) Int. J. Cancer , vol.127 , pp. 2718-2722
    • Janeway, K.A.1    Zhu, M.J.2    Barretina, J.3    Perez-Atayde, A.4    Demetri, G.D.5    Fletcher, J.A.6
  • 87
    • 34248170187 scopus 로고    scopus 로고
    • Functional responses and in vivo anti-tumour activity of h7C10: A humanised monoclonal antibody with neutralizing activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors
    • Pandini, G.; Wurch, T.; Akla, B.; Corvaia, N.; Belfiore, A.; Goetsch, L. Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralizing activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur. J. Cancer 2007, 43, 1318-1327.
    • (2007) Eur. J. Cancer , vol.43 , pp. 1318-1327
    • Pandini, G.1    Wurch, T.2    Akla, B.3    Corvaia, N.4    Belfiore, A.5    Goetsch, L.6
  • 88
    • 79953647468 scopus 로고    scopus 로고
    • Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer
    • Buck, E.; Mulvihill, M. Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert. Opin. Investig. Drugs 2011, 20, 605-621.
    • (2011) Expert. Opin. Investig. Drugs , vol.20 , pp. 605-621
    • Buck, E.1    Mulvihill, M.2
  • 90
    • 34548018304 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor in cancer: Old focus, new future
    • Hartog, H.; Wesseling, J.; Boezen, H.M.; van der Graaf, W.T. The insulin-like growth factor 1 receptor in cancer: Old focus, new future. Eur. J. Cancer 2007, 43, 1895-1904.
    • (2007) Eur. J. Cancer , vol.43 , pp. 1895-1904
    • Hartog, H.1    Wesseling, J.2    Boezen, H.M.3    van der Graaf, W.T.4
  • 91
    • 79959265311 scopus 로고    scopus 로고
    • Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations
    • 2011
    • Olmos, D.; Martins, A.S.; Jones, R.L.; Alam, S.; Scurr, M.; Judson, I.R. Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations. Sarcoma 2011, 2011, 402508.
    • (2011) Sarcoma , pp. 402508
    • Olmos, D.1    Martins, A.S.2    Jones, R.L.3    Alam, S.4    Scurr, M.5    Judson, I.R.6
  • 93
    • 0037146220 scopus 로고    scopus 로고
    • Potential use of imatinib in Ewing's Sarcoma: Evidence for in vitro and in vivo activity
    • Merchant, M.S.; Woo, C.W.; Mackall, C.L.; Thiele, C.J. Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity. J. Natl. Cancer Inst. 2002, 94, 1673-1679.
    • (2002) J. Natl. Cancer Inst , vol.94 , pp. 1673-1679
    • Merchant, M.S.1    Woo, C.W.2    Mackall, C.L.3    Thiele, C.J.4
  • 97
    • 38749092531 scopus 로고    scopus 로고
    • In vitro antiproliferative and antimigratory activity of dasatinib in neuroblastoma and Ewing sarcoma cell lines
    • Timeus, F.; Crescenzio, N.; Fandi, A.; Doria, A.; Foglia, L.; Cordero di Montezemolo, L. In vitro antiproliferative and antimigratory activity of dasatinib in neuroblastoma and Ewing sarcoma cell lines. Oncol. Rep. 2008, 19, 353-359.
    • (2008) Oncol. Rep , vol.19 , pp. 353-359
    • Timeus, F.1    Crescenzio, N.2    Fandi, A.3    Doria, A.4    Foglia, L.5    di Montezemolo, C.L.6
  • 98
    • 33745212417 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor
    • Martins, A.S.; Mackintosh, C.; Martin, D.H.; Campos, M.; Hernandez, T.; Ordonez, J.L.; de Alava, E. Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor. Clin. Cancer Res. 2006, 12, 3532-3540.
    • (2006) Clin. Cancer Res , vol.12 , pp. 3532-3540
    • Martins, A.S.1    Mackintosh, C.2    Martin, D.H.3    Campos, M.4    Hernandez, T.5    Ordonez, J.L.6    de Alava, E.7
  • 99
    • 39049101435 scopus 로고    scopus 로고
    • Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib
    • Andersson, M.K.; Aman, P. Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib. Cancer Cell. Int. 2008, 8, 1.
    • (2008) Cancer Cell. Int , vol.8 , pp. 1
    • Andersson, M.K.1    Aman, P.2
  • 102
    • 0037816235 scopus 로고    scopus 로고
    • Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
    • Girnita, L.; Girnita, A.; Larsson, O. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc. Natl. Acad. Sci. USA 2003, 100, 8247-8252.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8247-8252
    • Girnita, L.1    Girnita, A.2    Larsson, O.3
  • 103
    • 53649093334 scopus 로고    scopus 로고
    • Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival
    • Froment, P.; Dupont, J.; Christophe-Marine, J. Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival. Cell Cycle 2008, 7, 3098-3103.
    • (2008) Cell Cycle , vol.7 , pp. 3098-3103
    • Froment, P.1    Dupont, J.2    Christophe-Marine, J.3
  • 104
    • 0027281872 scopus 로고
    • Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours
    • Kovar, H.; Auinger, A.; Jug, G.; Aryee, D.; Zoubek, A.; Salzer-Kuntschik, M.; Gadner, H. Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours. Oncogene 1993, 8, 2683-2690.
    • (1993) Oncogene , vol.8 , pp. 2683-2690
    • Kovar, H.1    Auinger, A.2    Jug, G.3    Aryee, D.4    Zoubek, A.5    Salzer-Kuntschik, M.6    Gadner, H.7
  • 105
    • 54249157471 scopus 로고    scopus 로고
    • Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
    • Cao, L.; Yu, Y.; Darko, I.; Currier, D.; Mayeenuddin, L.H.; Wan, X.; Khanna, C.; Helman, L.J. Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody. Cancer Res. 2008, 68, 8039-8048.
    • (2008) Cancer Res , vol.68 , pp. 8039-8048
    • Cao, L.1    Yu, Y.2    Darko, I.3    Currier, D.4    Mayeenuddin, L.H.5    Wan, X.6    Khanna, C.7    Helman, L.J.8
  • 106
    • 28544446695 scopus 로고    scopus 로고
    • Biomarkers in cancer staging, prognosis and treatment selection
    • Ludwig, J.A.; Weinstein, J.N. Biomarkers in cancer staging, prognosis and treatment selection. Nat. Rev. Cancer 2005, 5, 845-856.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 845-856
    • Ludwig, J.A.1    Weinstein, J.N.2
  • 110
    • 79955991871 scopus 로고    scopus 로고
    • 18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer
    • McKinley, E.T.; Bugaj, J.E.; Zhao, P.; Guleryuz, S.; Mantis, C.; Gokhale, P.C.; Wild, R.; Manning, H.C. 18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer. Clin. Cancer Res. 2011, 17, 3332-3340.
    • (2011) Clin. Cancer Res , vol.17 , pp. 3332-3340
    • McKinley, E.T.1    Bugaj, J.E.2    Zhao, P.3    Guleryuz, S.4    Mantis, C.5    Gokhale, P.C.6    Wild, R.7    Manning, H.C.8
  • 114
    • 2642518825 scopus 로고    scopus 로고
    • Co-targeting IGF-1R and c-kit: Synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells
    • Camirand, A.; Pollak, M. Co-targeting IGF-1R and c-kit: Synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells. Br. J. Cancer 2004, 90, 1825-1829.
    • (2004) Br. J. Cancer , vol.90 , pp. 1825-1829
    • Camirand, A.1    Pollak, M.2
  • 119
    • 70349464846 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway
    • Nguyen, K.S.; Kobayashi, S.; Costa, D.B. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin. Lung Cancer 2009, 10, 281-289.
    • (2009) Clin. Lung Cancer , vol.10 , pp. 281-289
    • Nguyen, K.S.1    Kobayashi, S.2    Costa, D.B.3
  • 124
    • 33748927940 scopus 로고    scopus 로고
    • Interaction of IGF signaling and the androgen receptor in prostate cancer progression
    • Wu, J.D.; Haugk, K.; Woodke, L.; Nelson, P.; Coleman, I.; Plymate, S.R. Interaction of IGF signaling and the androgen receptor in prostate cancer progression. J. Cell. Biochem. 2006, 99, 392-401.
    • (2006) J. Cell. Biochem , vol.99 , pp. 392-401
    • Wu, J.D.1    Haugk, K.2    Woodke, L.3    Nelson, P.4    Coleman, I.5    Plymate, S.R.6
  • 125
    • 79851471665 scopus 로고    scopus 로고
    • Measuring IGF-1, ER-alpha and EGFR expression can predict tamoxifen-resistance in ER-positive breast cancer
    • Chong, K.; Subramanian, A.; Sharma, A.; Mokbel, K. Measuring IGF-1, ER-alpha and EGFR expression can predict tamoxifen-resistance in ER-positive breast cancer. Anticancer Res. 2011, 31, 23-32.
    • (2011) Anticancer Res , vol.31 , pp. 23-32
    • Chong, K.1    Subramanian, A.2    Sharma, A.3    Mokbel, K.4
  • 126
    • 80051551846 scopus 로고    scopus 로고
    • The prognostic significance of the insulin-like growth factor-1 ligand and receptor expression in breast cancer tissue
    • 10.1002/jso.21916
    • Chong, K.Y.; Subramanian, A.; Mokbel, K.; Sharma, A.K. The prognostic significance of the insulin-like growth factor-1 ligand and receptor expression in breast cancer tissue. J. Surg. Oncol. 2011, 10.1002/jso.21916.
    • (2011) J. Surg. Oncol
    • Chong, K.Y.1    Subramanian, A.2    Mokbel, K.3    Sharma, A.K.4
  • 127
    • 1242341918 scopus 로고    scopus 로고
    • The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane
    • Song, R.X.; Barnes, C.J.; Zhang, Z.; Bao, Y.; Kumar, R.; Santen, R.J. The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane. Proc. Natl. Acad. Sci. USA 2004, 101, 2076-2081.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2076-2081
    • Song, R.X.1    Barnes, C.J.2    Zhang, Z.3    Bao, Y.4    Kumar, R.5    Santen, R.J.6
  • 128
    • 0036137605 scopus 로고    scopus 로고
    • Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation
    • Song, R.X.; McPherson, R.A.; Adam, L.; Bao, Y.; Shupnik, M.; Kumar, R.; Santen, R.J. Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation. Mol. Endocrinol. 2002, 16, 116-127.
    • (2002) Mol. Endocrinol , vol.16 , pp. 116-127
    • Song, R.X.1    McPherson, R.A.2    Adam, L.3    Bao, Y.4    Shupnik, M.5    Kumar, R.6    Santen, R.J.7
  • 130
    • 70350214534 scopus 로고    scopus 로고
    • Kaufmann, S.H. Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: Effect of the dual-receptor inhibitor BMS-536924 in vitro
    • Wahner Hendrickson, A.E.; Haluska, P.; Schneider, P.A.; Loegering, D.A.; Peterson, K.L.; Attar, R.; Smith, B.D.; Erlichman, C.; Gottardis, M.; Karp, J.E.; Carboni, J.M.; Kaufmann, S.H. Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: Effect of the dual-receptor inhibitor BMS-536924 in vitro. Cancer Res. 2009, 69, 7635-7643.
    • (2009) Cancer Res , vol.69 , pp. 7635-7643
    • Wahner Hendrickson, A.E.1    Haluska, P.2    Schneider, P.A.3    Loegering, D.A.4    Peterson, K.L.5    Attar, R.6    Smith, B.D.7    Erlichman, C.8    Gottardis, M.9    Karp, J.E.10    Carboni, J.M.11
  • 133
    • 77953973648 scopus 로고    scopus 로고
    • Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
    • Ulanet, D.B.; Ludwig, D.L.; Kahn, C.R.; Hanahan, D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc. Natl. Acad. Sci. USA 2010, 107, 10791-10798.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 10791-10798
    • Ulanet, D.B.1    Ludwig, D.L.2    Kahn, C.R.3    Hanahan, D.4
  • 134
    • 33746867442 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo
    • Jerome, L.; Alami, N.; Belanger, S.; Page, V.; Yu, Q.; Paterson, J.; Shiry, L.; Pegram, M.; Leyland-Jones, B. Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo. Cancer Res. 2006, 66, 7245-7252.
    • (2006) Cancer Res , vol.66 , pp. 7245-7252
    • Jerome, L.1    Alami, N.2    Belanger, S.3    Page, V.4    Yu, Q.5    Paterson, J.6    Shiry, L.7    Pegram, M.8    Leyland-Jones, B.9
  • 135
    • 53249138207 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models
    • Alami, N.; Page, V.; Yu, Q.; Jerome, L.; Paterson, J.; Shiry, L.; Leyland-Jones, B. Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models. Growth Horm. IGF Res. 2008, 18, 487-496.
    • (2008) Growth Horm. IGF Res , vol.18 , pp. 487-496
    • Alami, N.1    Page, V.2    Yu, Q.3    Jerome, L.4    Paterson, J.5    Shiry, L.6    Leyland-Jones, B.7
  • 136
    • 0036963448 scopus 로고    scopus 로고
    • Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells
    • Camirand, A.; Lu, Y.; Pollak, M. Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells. Med. Sci. Monit. 2002, 8, BR521-526.
    • (2002) Med. Sci. Monit , vol.8
    • Camirand, A.1    Lu, Y.2    Pollak, M.3
  • 138
    • 33646227448 scopus 로고    scopus 로고
    • Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy
    • Tonra, J.R.; Deevi, D.S.; Corcoran, E.; Li, H.; Wang, S.; Carrick, F.E.; Hicklin, D.J. Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy. Clin. Cancer Res. 2006, 12, 2197-2207.
    • (2006) Clin. Cancer Res , vol.12 , pp. 2197-2207
    • Tonra, J.R.1    Deevi, D.S.2    Corcoran, E.3    Li, H.4    Wang, S.5    Carrick, F.E.6    Hicklin, D.J.7
  • 139
    • 0035804218 scopus 로고    scopus 로고
    • Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells
    • Balana, M.E.; Labriola, L.; Salatino, M.; Movsichoff, F.; Peters, G.; Charreau, E.H.; Elizalde, P.V. Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells. Oncogene 2001, 20, 34-47.
    • (2001) Oncogene , vol.20 , pp. 34-47
    • Balana, M.E.1    Labriola, L.2    Salatino, M.3    Movsichoff, F.4    Peters, G.5    Charreau, E.H.6    Elizalde, P.V.7
  • 141
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • LeRoith, D.; Roberts, C.T., Jr. The insulin-like growth factor system and cancer. Cancer Lett. 2003, 195, 127-137.
    • (2003) Cancer Lett , vol.195 , pp. 127-137
    • Leroith, D.1    Roberts Jr., C.T.2
  • 142
    • 35948977339 scopus 로고    scopus 로고
    • Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signaltransducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth
    • Lang, S.A.; Moser, C.; Gaumann, A.; Klein, D.; Glockzin, G.; Popp, F.C.; Dahlke, M.H.; Piso, P.; Schlitt, H.J.; Geissler, E.K.; Stoeltzing, O. Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signaltransducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth. Clin. Cancer Res. 2007, 13, 6459-6468.
    • (2007) Clin. Cancer Res , vol.13 , pp. 6459-6468
    • Lang, S.A.1    Moser, C.2    Gaumann, A.3    Klein, D.4    Glockzin, G.5    Popp, F.C.6    Dahlke, M.H.7    Piso, P.8    Schlitt, H.J.9    Geissler, E.K.10    Stoeltzing, O.11
  • 143
    • 62749203737 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 receptor targeted therapeutics: Novel compounds and novel treatment strategies for cancer medicine
    • Hewish, M.; Chau, I.; Cunningham, D. Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. Recent Pat. Anticancer Drug Discov. 2009, 4, 54-72.
    • (2009) Recent Pat. Anticancer Drug Discov , vol.4 , pp. 54-72
    • Hewish, M.1    Chau, I.2    Cunningham, D.3
  • 144
    • 79954614279 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor network in cancer therapy
    • Heidegger, I.; Pircher, A.; Klocker, H.; Massoner, P. Targeting the insulin-like growth factor network in cancer therapy. Cancer Biol. Ther. 2011, 11, 701-707.
    • (2011) Cancer Biol. Ther , vol.11 , pp. 701-707
    • Heidegger, I.1    Pircher, A.2    Klocker, H.3    Massoner, P.4
  • 145
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • Haruta, T.; Uno, T.; Kawahara, J.; Takano, A.; Egawa, K.; Sharma, P.M.; Olefsky, J.M.; Kobayashi, M. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol. Endocrinol. 2000, 14, 783-794.
    • (2000) Mol. Endocrinol , vol.14 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3    Takano, A.4    Egawa, K.5    Sharma, P.M.6    Olefsky, J.M.7    Kobayashi, M.8
  • 146
    • 34248136479 scopus 로고    scopus 로고
    • Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
    • Liu, T.J.; LaFortune, T.; Honda, T.; Ohmori, O.; Hatakeyama, S.; Meyer, T.; Jackson, D.; de Groot, J.; Yung, W.K. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol. Cancer Ther. 2007, 6, 1357-1367.
    • (2007) Mol. Cancer Ther , vol.6 , pp. 1357-1367
    • Liu, T.J.1    Lafortune, T.2    Honda, T.3    Ohmori, O.4    Hatakeyama, S.5    Meyer, T.6    Jackson, D.7    de Groot, J.8    Yung, W.K.9
  • 147
    • 46949105858 scopus 로고    scopus 로고
    • FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells
    • Liu, W.; Bloom, D.A.; Cance, W.G.; Kurenova, E.V.; Golubovskaya, V.M.; Hochwald, S.N. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 2008, 29, 1096-1107.
    • (2008) Carcinogenesis , vol.29 , pp. 1096-1107
    • Liu, W.1    Bloom, D.A.2    Cance, W.G.3    Kurenova, E.V.4    Golubovskaya, V.M.5    Hochwald, S.N.6
  • 150
    • 0025066358 scopus 로고
    • Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer
    • Bonneterre, J.; Peyrat, J.P.; Beuscart, R.; Demaille, A. Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer. Cancer Res. 1990, 50, 6931-6935.
    • (1990) Cancer Res , vol.50 , pp. 6931-6935
    • Bonneterre, J.1    Peyrat, J.P.2    Beuscart, R.3    Demaille, A.4
  • 153
    • 57149142362 scopus 로고    scopus 로고
    • Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer
    • Jin, Q.; Esteva, F.J. Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer. J. Mammary Gland Biol. Neoplasia 2008, 13, 485-498.
    • (2008) J. Mammary Gland Biol. Neoplasia , vol.13 , pp. 485-498
    • Jin, Q.1    Esteva, F.J.2
  • 154
    • 33745924420 scopus 로고    scopus 로고
    • Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells
    • Jones, H.E.; Gee, J.M.; Barrow, D.; Tonge, D.; Holloway, B.; Nicholson, R.I. Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells. Br. J. Cancer 2006, 95, 172-180.
    • (2006) Br. J. Cancer , vol.95 , pp. 172-180
    • Jones, H.E.1    Gee, J.M.2    Barrow, D.3    Tonge, D.4    Holloway, B.5    Nicholson, R.I.6
  • 155
    • 33750211376 scopus 로고    scopus 로고
    • Predicted mechanisms of resistance to mTOR inhibitors
    • Kurmasheva, R.T.; Huang, S.; Houghton, P.J. Predicted mechanisms of resistance to mTOR inhibitors. Br. J. Cancer 2006, 95, 955-960.
    • (2006) Br. J. Cancer , vol.95 , pp. 955-960
    • Kurmasheva, R.T.1    Huang, S.2    Houghton, P.J.3
  • 156
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • Wan, X.; Harkavy, B.; Shen, N.; Grohar, P.; Helman, L.J. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007, 26, 1932-1940.
    • (2007) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 157
    • 34247370642 scopus 로고    scopus 로고
    • Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer
    • Masiello, D.; Mohi, M.G.; McKnight, N.C.; Smith, B.; Neel, B.G.; Balk, S.P.; Bubley, G.J. Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer. Cancer Biol. Ther. 2007, 6, 195-201.
    • (2007) Cancer Biol. Ther , vol.6 , pp. 195-201
    • Masiello, D.1    Mohi, M.G.2    McKnight, N.C.3    Smith, B.4    Neel, B.G.5    Balk, S.P.6    Bubley, G.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.