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Volumn 3, Issue 1, 2011, Pages 30-56

New molecular targeted therapies for advanced non-small-cell lung cancer

Author keywords

Advanced non small cell lung cancer; Angiogenesis; EML4 ALK fusion oncogene; Epidermal growth factor receptor (EGFR); Histone deacetylase Inhibition; Immunotherapy; Insulin like growth factor 1 receptor (IGF 1R); Proteasome inhibition; Targeted therapies

Indexed keywords


EID: 80052437059     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.3978/j.issn.2072-1439.2010.12.03     Document Type: Review
Times cited : (32)

References (134)
  • 5
    • 11344268358 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor
    • Camp ER, Summy J, Bauer TW, Liu W, Gallick GE, Ellis LM. Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor. Clin Cancer Res 2005;11:397-405.
    • (2005) Clin Cancer Res , vol.11 , pp. 397-405
    • Camp, E.R.1    Summy, J.2    Bauer, T.W.3    Liu, W.4    Gallick, G.E.5    Ellis, L.M.6
  • 8
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 2007;104:20932-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 10
    • 37549061078 scopus 로고    scopus 로고
    • PF00299804, an irreversible par-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
    • Engelman JA, Zejnullahu K, Gale CM, Lifshits E, Gonzales AJ, Shimamura T, et al. PF00299804, an irreversible par-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res 2007;67:11924-32.
    • (2007) Cancer Res , vol.67 , pp. 11924-11932
    • Engelman, J.A.1    Zejnullahu, K.2    Gale, C.M.3    Lifshits, E.4    Gonzales, A.J.5    Shimamura, T.6
  • 11
    • 56349167837 scopus 로고    scopus 로고
    • Preliminary activity and safety results from a phase I clinical trial of PF-00299804, an irreversible pan-HER inhibitor, in patients (pts) with NSCLC [abstract]
    • Janne PA, Schellens JH, Engelman JA, Eckhardt SG, Millham R, Denis LJ, et al. Preliminary activity and safety results from a phase I clinical trial of PF-00299804, an irreversible pan-HER inhibitor, in patients (pts) with NSCLC [abstract]. J Clin Oncol 2008;s26:8027.
    • (2008) J Clin Oncol , vol.s26 , pp. 8027
    • Janne, P.A.1    Schellens, J.H.2    Engelman, J.A.3    Eckhardt, S.G.4    Millham F, R.5    Denis, L.J.6
  • 12
    • 79952535822 scopus 로고    scopus 로고
    • PF-00299804 (PF299) in Asian patients (pts) with non-small cell lung cancer (NSCLC) refractory to chemotherapy (CT) and erlotinib (E) or gefitinib (G): A phase (P) I/II trial [abstract]
    • Park K, Heo DS, Cho B, Kim D, Ahn M, Lee S, et al. PF-00299804 (PF299) in Asian patients (pts) with non-small cell lung cancer (NSCLC) refractory to chemotherapy (CT) and erlotinib (E) or gefitinib (G): A phase (P) I/II trial [abstract]. J Clin Oncol 2010;s28:7599.
    • (2010) J Clin Oncol , vol.s28 , pp. 7599
    • Park, K.1    Heo, D.S.2    Cho, B.3    Kim, D.4    Ahn, M.5    Lee, S.6
  • 13
    • 78649505590 scopus 로고    scopus 로고
    • PF-00299804 (PF299) patients (pt)-reported outcomes (PROs) and efficacy in adenocarcinoma (adeno) and nonadeno non-small cell lung cancer (NSCLC): A phase (P) II trial in advanced NSCLC after failure of chemotherapy (CT) and erlotinib (E) [abstract]
    • Campbell A, Reckamp KL, Camidge DR, Giaccone G, Gadgeel SM, Khuri FR, et al. PF-00299804 (PF299) patients (pt)-reported outcomes (PROs) and efficacy in adenocarcinoma (adeno) and nonadeno non-small cell lung cancer (NSCLC): A phase (P) II trial in advanced NSCLC after failure of chemotherapy (CT) and erlotinib (E) [abstract]. J Clin Oncol 2010;s28:7596.
    • (2010) J Clin Oncol , vol.s28 , pp. 7596
    • Campbell, A.1    Reckamp, K.L.2    Camidge, D.R.3    Giaccone, G.4    Gadgeel, S.M.5    Khuri, F.R.6
  • 14
    • 77958011527 scopus 로고    scopus 로고
    • Efficacy and safety of PF299804 versus erlotinib (E): A global, randomized phase II trial in patients (pts) with advanced nn-small cell lung cancer (NSCLC) after failure of chemotherapy (CT) [abstract]
    • Boyer MJ, Blackhall FH, Park K, Barrios CH, Krzakowski MJ, Taylor I, et al. Efficacy and safety of PF299804 versus erlotinib (E): A global, randomized phase II trial in patients (pts) with advanced nn-small cell lung cancer (NSCLC) after failure of chemotherapy (CT) [abstract]. J Clin Oncol 2010;s28:LBA7523.
    • (2010) J Clin Oncol , vol.s28
    • Boyer, M.J.1    Blackhall, F.H.2    Park, K.3    Barrios, C.H.4    Krzakowski, M.J.5    Taylor, I.6
  • 15
    • 34547749490 scopus 로고    scopus 로고
    • HKI-272 in non small cell lung cancer
    • Wong KK. HKI-272 in non small cell lung cancer. Clin Cancer Res 2007;13:4593-6.
    • (2007) Clin Cancer Res , vol.13 , pp. 4593-4596
    • Wong, K.K.1
  • 16
    • 77954584507 scopus 로고    scopus 로고
    • Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer
    • Sequist LV, Besse B, Lynch TJ, Miller VA, Wong KK, Gitlitz B, et al.Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer. J Clin Oncol 2010;28:3076-83
    • (2010) J Clin Oncol , vol.28 , pp. 3076-3083
    • Sequist, L.V.1    Besse, B.2    Lynch, T.J.3    Miller, V.A.4    Wong, K.K.5    Gitlitz, B.6
  • 17
    • 33847371736 scopus 로고    scopus 로고
    • Allele dependent variation in the relative cellular potency of distint EGFR inhibitors
    • Yuza Y, Glatt KA, Jiang J, Greulich H, Minami Y, Woo MS, et al. Allele dependent variation in the relative cellular potency of distint EGFR inhibitors. Cancer Biol Ther 2007;6:661-7.
    • (2007) Cancer Biol Ther , vol.6 , pp. 661-667
    • Yuza, Y.1    Glatt, K.A.2    Jiang, J.3    Greulich, H.4    Minami, Y.5    Woo, M.S.6
  • 20
    • 59349102359 scopus 로고    scopus 로고
    • A phase I study of XL647, an EGFR, HER2, VEGFR2 inhibitor, administered orally daily to patients (pts) with advanced solid malignancies (ASM) [abstract]
    • Wakelee HA, Fehling JM, Molina JR, Lensing JL, Funke RP, Miles D, et al. A phase I study of XL647, an EGFR, HER2, VEGFR2 inhibitor, administered orally daily to patients (pts) with advanced solid malignancies (ASM) [abstract]. J Clin Oncol 2008;s26:3528.
    • (2008) J Clin Oncol , vol.s26 , pp. 3528
    • Wakelee, H.A.1    Fehling, J.M.2    Molina, J.R.3    Lensing, J.L.4    Funke, R.P.5    Miles, D.6
  • 21
    • 56349165038 scopus 로고    scopus 로고
    • Activity of XL647 in clinically selected NSCLC patients (pts) enriched for the presence of EGFR mutation: Results from Phase 2 [abstract]
    • Rizvi NA, Kris MG, Miller VA, Krug LM, Bekele S, Dowlati A, et al. Activity of XL647 in clinically selected NSCLC patients (pts) enriched for the presence of EGFR mutation: Results from Phase 2 [abstract]. J Clin Oncol 2008;s26:8053.
    • (2008) J Clin Oncol , vol.s26 , pp. 8053
    • Rizvi, N.A.1    Kris, M.G.2    Miller, V.A.3    Krug, L.M.4    Bekele, S.5    Dowlati, A.6
  • 22
    • 56349121456 scopus 로고    scopus 로고
    • Activity and tolerance of XL647 in NSCLC patients with acquired resistance to EGFR-TKIs: Preliminary results of a phase II trial [abstract]
    • Miller VA, Wakelee HA, Lara PN, Cho J, Chowhan NM, Costa D, et al. Activity and tolerance of XL647 in NSCLC patients with acquired resistance to EGFR-TKIs: Preliminary results of a phase II trial [abstract]. J Clin Oncol 2008;s26:8028.
    • (2008) J Clin Oncol , vol.s26 , pp. 8028
    • Miller, V.A.1    Wakelee, H.A.2    Lara, P.N.3    Cho, J.4    Chowhan, N.M.5    Costa, D.6
  • 23
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008;27:4702-11.
    • (2008) Oncogene , vol.27 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3    Kubo, S.4    Takahashi, M.5    Chirieac, L.R.6
  • 24
    • 56349144572 scopus 로고    scopus 로고
    • Use of BIBW 2992, a novel irreversible EGFR/HER2 TKI, to induce regression in patients with adenocarcinoma of the lung and activating EGFR mutations: Preliminary results of a single-arm phase II clinical trial [abstract]
    • Yang C, Shih J, Chao T, Tsai C, Yu C, Yang P, et al. Use of BIBW 2992, a novel irreversible EGFR/HER2 TKI, to induce regression in patients with adenocarcinoma of the lung and activating EGFR mutations: Preliminary results of a single-arm phase II clinical trial [abstract]. J Clin Oncol 2008;s26:8026.
    • (2008) J Clin Oncol , vol.s26 , pp. 8026
    • Yang, C.1    Shih, J.2    Chao, T.3    Tsai, C.4    Yu, C.5    Yang, P.6
  • 25
    • 75449107400 scopus 로고    scopus 로고
    • Phase IIb/III double-blind randomized trial of BIBW 2992, an irreversible, dual inhibitor of EGFR and HER2 plus best supportive care (BSC) versus placebo plus BSC in patients with NSCLC failing 1-2 lines of chemotherapy (CT) and erlotinib or gefitinib (LUX-Lung1): A preliminary report [abstract]
    • Yang C, Hirsh V, Cadranel J, Chen Y, Park K, Kim S, et al. Phase IIb/III double-blind randomized trial of BIBW 2992, an irreversible, dual inhibitor of EGFR and HER2 plus best supportive care (BSC) versus placebo plus BSC in patients with NSCLC failing 1-2 lines of chemotherapy (CT) and erlotinib or gefitinib (LUX-Lung1): A preliminary report [abstract]. J Clin Oncol 2009;s27:8062.
    • (2009) J Clin Oncol , vol.s27 , pp. 8062
    • Yang, C.1    Hirsh, V.2    Cadranel, J.3    Chen, Y.4    Park, K.5    Kim, S.6
  • 26
    • 23844544081 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
    • Holden SN, Eckhardt SG, Basser R, de Boer R, Rischin D, Green M, et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol 2005;16:1391-7.
    • (2005) Ann Oncol , vol.16 , pp. 1391-1397
    • Holden, S.N.1    Eckhardt, S.G.2    Basser, R.3    de Boer, R.4    Rischin, D.5    Green, M.6
  • 27
    • 33846844387 scopus 로고    scopus 로고
    • A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors
    • Tamura T, Minami H, Yamada Y, Yamamoto N, Shimoyama T, Murakami H, et al. A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors. J Thorac Oncol 2006;1:1002-9.
    • (2006) J Thorac Oncol , vol.1 , pp. 1002-1009
    • Tamura, T.1    Minami, H.2    Yamada, Y.3    Yamamoto, N.4    Shimoyama, T.5    Murakami, H.6
  • 28
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results form a two-part, double-blind, randomized phase II study
    • Natale RB, Bodkin D, Govindan R, Sleckman BG, Rizvi NA, Capó A, et al. Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results form a two-part, double-blind, randomized phase II study. J Clin Oncol 2009;27:2523-9.
    • (2009) J Clin Oncol , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3    Sleckman, B.G.4    Rizvi, N.A.5    Capó, A.6
  • 29
    • 56749102822 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • Heymach JV, Paz-Ares L, De Braud F, Sebastian M, Stewart DJ, Eberhardt WE, et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008;26:5407-15.
    • (2008) J Clin Oncol , vol.26 , pp. 5407-5415
    • Heymach, J.V.1    Paz-Ares, L.2    De Braud, F.3    Sebastian, M.4    Stewart, D.J.5    Eberhardt, W.E.6
  • 30
    • 34948838898 scopus 로고    scopus 로고
    • A randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non-small-cell lung cancer
    • Heymach JV, Johnson BE, Prager D, Csada E, Roubec J, Pesek M, et al. A randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non-small-cell lung cancer. J Clin Oncol 2007;25:4270-7.
    • (2007) J Clin Oncol , vol.25 , pp. 4270-4277
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3    Csada, E.4    Roubec, J.5    Pesek, M.6
  • 31
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WE, Germonpré P, Saijo N, Zhou C, et al. Vandetanib plus docetaxel versus docetaxel as second line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 2010;11:619-26.
    • (2010) Lancet Oncol , vol.11 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3    Germonpré, P.4    Saijo, N.5    Zhou, C.6
  • 32
    • 70349474058 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double blind phase III trial (ZEAL) [abstract]
    • De Boer R, Arrieta O, Gottfried M, Blackhall FH, Raats J, Yang CH, et al. Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double blind phase III trial (ZEAL) [abstract]. J Clin Oncol 2009;s27:8010.
    • (2009) J Clin Oncol , vol.s27 , pp. 8010
    • De Boer, R.1    Arrieta, O.2    Gottfried, M.3    Blackhall, F.H.4    Raats, J.5    Yang, C.H.6
  • 33
    • 78049395323 scopus 로고    scopus 로고
    • Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind phase III trial (ZEPHYR) [abstract]
    • Lee J, Hirsch V, Park K, Qin S, Blajman CR, Perng R, et al. Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind phase III trial (ZEPHYR) [abstract]. J Clin Oncol 2010;s28:7525.
    • (2010) J Clin Oncol , vol.s28 , pp. 7525
    • Lee, J.1    Hirsch, V.2    Park, K.3    Qin, S.4    Blajman, C.R.5    Perng, R.6
  • 34
    • 70349476412 scopus 로고    scopus 로고
    • Sunpaweravong P, et al. Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST) [abstract]
    • Natale RB, Thongprasert S, Greco FA, Thomas M, Tsai CM, Sunpaweravong P, et al. Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST) [abstract]. J Clin Oncol 2009;s27:8009.
    • (2009) J Clin Oncol , vol.s27 , pp. 8009
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3    Thomas, M.4    Tsai, C.M.5
  • 35
    • 42949105645 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of daily oral AZD, 2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer: The National Cancer Institute of Canada Clinical Trials Group
    • Laurie SA, Gauthier I, Arnold A, Shepherd FA, Ellis PM, Chen E, et al. Phase I and pharmacokinetic study of daily oral AZD 2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer: The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2008;26:1871-8.
    • (2008) J Clin Oncol , vol.26 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3    Shepherd, F.A.4    Ellis, P.M.5    Chen, E.6
  • 36
    • 61349124193 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: A study of the National Cancer Institute of Canada Clinical Trials Group
    • Goss G, Shepherd FA, Laurie S, Gauthier I, Leighl N, Chen E, et al. A phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: A study of the National Cancer Institute of Canada Clinical Trials Group. Eur J Cancer 2009;45:782-8.
    • (2009) Eur J Cancer , vol.45 , pp. 782-788
    • Goss, G.1    Shepherd, F.A.2    Laurie, S.3    Gauthier, I.4    Leighl, N.5    Chen, E.6
  • 37
    • 73949092851 scopus 로고    scopus 로고
    • Randomized, double blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 Study
    • Goss GD, Arnold A, Shepherd FA, Dediu M, Ciuleanu TE, Fenton D, et al. Randomized, double blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 Study. J Clin Oncol 2009;28:49-55.
    • (2009) J Clin Oncol , vol.28 , pp. 49-55
    • Goss, G.D.1    Arnold, A.2    Shepherd, F.A.3    Dediu, M.4    Ciuleanu, T.E.5    Fenton, D.6
  • 38
    • 78049411804 scopus 로고    scopus 로고
    • A randomized phase II study of gemcitabine (G) and carboplatin (C) with or without cediranib (AZD2171 [CED] as first-line therapy in advanced non-small cell lung cancer (NSCLC) [abstract]
    • Dy GK, Mandrkar SJ, Nelson GD, Ross HJ, Ansari RH, Lyss AP, et al. A randomized phase II study of gemcitabine (G) and carboplatin (C) with or without cediranib (AZD2171 [CED] as first-line therapy in advanced non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2010;s28:7603.
    • (2010) J Clin Oncol , vol.s28 , pp. 7603
    • Dy, G.K.1    Mandrkar, S.J.2    Nelson, G.D.3    Ross, H.J.4    Ansari, R.H.5    Lyss, A.P.6
  • 40
    • 39149120621 scopus 로고    scopus 로고
    • Multicenter, phase II trial of sunitinib in previously treated, advanced non-small cell lung cancer
    • Socinski MA, Novello S, Brahmer JR, Rosell R, Sanchez JM, Belani CP, et al. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small cell lung cancer. J Clin Oncol 2008; 26:650-6.
    • (2008) J Clin Oncol , vol.26 , pp. 650-656
    • Socinski, M.A.1    Novello, S.2    Brahmer, J.R.3    Rosell, R.4    Sanchez, J.M.5    Belani, C.P.6
  • 41
    • 70350655546 scopus 로고    scopus 로고
    • Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer
    • Novello S, Scagliotti GV, Rosell R, Socinski MA, Brahmer J, Atkins J, et al. Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer. Br J Cancer 2009;101:1543-8.
    • (2009) Br J Cancer , vol.101 , pp. 1543-1548
    • Novello, S.1    Scagliotti, G.V.2    Rosell, R.3    Socinski, M.A.4    Brahmer, J.5    Atkins, J.6
  • 42
    • 42949148257 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Burstein HJ, Elias AD, Rugo HS, Cobleigh MA, Wolff AC, Eisenberg PD, et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2008;26:1810-6.
    • (2008) J Clin Oncol , vol.26 , pp. 1810-1816
    • Burstein, H.J.1    Elias, A.D.2    Rugo, H.S.3    Cobleigh, M.A.4    Wolff, A.C.5    Eisenberg, P.D.6
  • 43
    • 84859006683 scopus 로고    scopus 로고
    • Phase II study of sunitinib in patients with advanced non-small cell lung cancer (NSCLC) and irradiated brain metastases: Final efficacy and safety results [abstract]
    • Novello S, Camps C, Grossi F, Mazieres J, Abrey LE, Vernejoux J, et al. Phase II study of sunitinib in patients with advanced non-small cell lung cancer (NSCLC) and irradiated brain metastases: Final efficacy and safety results [abstract]. J Clin Oncol 2010;s28:7581.
    • (2010) J Clin Oncol , vol.s28 , pp. 7581
    • Novello, S.1    Camps, C.2    Grossi, F.3    Mazieres, J.4    Abrey, L.E.5    Vernejoux, J.6
  • 44
    • 33748901860 scopus 로고    scopus 로고
    • Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: A phase I subset analysis [abstract]
    • Schiller JH, Flaherty KT, Redlinger M, Binger K, Eun J, Petrenciuc O, et al. Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: A phase I subset analysis [abstract]. J Clin Oncol 2006;s24:7194.
    • (2006) J Clin Oncol , vol.s24 , pp. 7194
    • Schiller, J.H.1    Flaherty, K.T.2    Redlinger, M.3    Binger, K.4    Eun, J.5    Petrenciuc, O.6
  • 45
    • 35548976756 scopus 로고    scopus 로고
    • A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: A North Central Cancer Treatment Group Study [abstract]
    • Adjei AA. A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: A North Central Cancer Treatment Group Study [abstract]. J Clin Oncol 2007;s5:7547.
    • (2007) J Clin Oncol , vol.s5 , pp. 7547
    • Adjei, A.A.1
  • 46
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small cell lung cancer [abstract]
    • Blumenschein GR Jr, Gatzemeier U, Fossella F, Stewart DJ, Cupit L, Cihon F, et al. Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small cell lung cancer [abstract]. J Clin Oncol 2009;27:4274-80.
    • (2009) J Clin Oncol , vol.27 , pp. 4274-4280
    • Blumenschein Jr., G.R.1    Gatzemeier, U.2    Fossella, F.3    Stewart, D.J.4    Cupit, L.5    Cihon, F.6
  • 47
    • 65349161533 scopus 로고    scopus 로고
    • A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501 [abstract]
    • Schiller J, Lee J, Hanna N, Traynor AM, Carbone DP. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501 [abstract]. J Clin Oncol 2008;s26:8014.
    • (2008) J Clin Oncol , vol.s26 , pp. 8014
    • Schiller, J.1    Lee, J.2    Hanna, N.3    Traynor, A.M.4    Carbone, D.P.5
  • 48
    • 78549289509 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer
    • Okamoto I, Miyazaki M, Morinaga R, Kaneda H, Ueda S, Hasegawa Y, et al. Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Invest New Drugs 2010;28:844-53.
    • (2010) Invest New Drugs , vol.28 , pp. 844-853
    • Okamoto, I.1    Miyazaki, M.2    Morinaga, R.3    Kaneda, H.4    Ueda, S.5    Hasegawa, Y.6
  • 49
    • 33748901860 scopus 로고    scopus 로고
    • Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: A phase I subset analysis [abstract]
    • Schiller JH, Flaherty KT, Redlinger M, Binger K, Eun J, Petrenciuc O, et al. Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: A phase I subset analysis [abstract]. J Clin Oncol 2006;s24:7194.
    • (2006) J Clin Oncol , vol.s24 , pp. 7194
    • Schiller, J.H.1    Flaherty, K.T.2    Redlinger, M.3    Binger, K.4    Eun, J.5    Petrenciuc, O.6
  • 50
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small cell lung cancer
    • Scagliotti G, Novello S, von Pawel J, Reck M, Pereira JR, Thomas M, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small cell lung cancer. J Clin Oncol 2010;28:1835-42.
    • (2010) J Clin Oncol , vol.28 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    von Pawel, J.3    Reck, M.4    Pereira, J.R.5    Thomas, M.6
  • 51
    • 34248140107 scopus 로고    scopus 로고
    • Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small cell lung cancer: The Tarceva Lung Cancer Investigation Trial
    • Gatzemeier U, Pluzanska A, Szczesna A, Kaukel E, Roubec J, De Rosa F, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small cell lung cancer: The Tarceva Lung Cancer Investigation Trial. J Clin Oncol 2007;25:1545-52.
    • (2007) J Clin Oncol , vol.25 , pp. 1545-1552
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3    Kaukel, E.4    Roubec, J.5    De Rosa, F.6
  • 52
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel carboplatin in non-small-cell lung cancer: A phase III trial- INTACT 2
    • Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C, et al. Gefitinib in combination with paclitaxel carboplatin in non-small-cell lung cancer: A phase III trial- INTACT 2. J Clin Oncol 2004;22:785-94.
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3    Natale, R.B.4    Miller, V.5    Manegold, C.6
  • 53
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U, Hogg D, Robert C, Hersey P, et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 2009;27:2823-30.
    • (2009) J Clin Oncol , vol.27 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3    Hogg, D.4    Robert, C.5    Hersey, P.6
  • 54
    • 68949127256 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib in patients with advanced non-small cell lung cancer: results from a phase II study
    • Schiller JH, Larson T, Ou SH, Limentani S, Sandler A, Vokes E, et al. Efficacy and safety of axitinib in patients with advanced non-small cell lung cancer: results from a phase II study. J Clin Oncol 2009;27:3836-31.
    • (2009) J Clin Oncol , vol.27 , pp. 3836-3931
    • Schiller, J.H.1    Larson, T.2    Ou, S.H.3    Limentani, S.4    Sandler, A.5    Vokes, E.6
  • 55
    • 64249099126 scopus 로고    scopus 로고
    • Phase II open-label study to investigate efficacy and safety of PTK787/ZK 222584 (PTK/ZK) orally administered once daily or twice daily at 1250 mg as second-line monotherapy in patients (pts) with stage IIIB/IV non-small cell lung cancer (NSCLC) [abstract]
    • Gauler TC, Besse B, Meric JB, Gounant V, Fischer B, Overbeck T, et al. Phase II open-label study to investigate efficacy and safety of PTK787/ZK 222584 (PTK/ZK) orally administered once daily or twice daily at 1250 mg as second-line monotherapy in patients (pts) with stage IIIB/IV non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2007;s25:7541.
    • (2007) J Clin Oncol , vol.s25 , pp. 7541
    • Gauler, T.C.1    Besse, B.2    Meric, J.B.3    Gounant, V.4    Fischer, B.5    Overbeck, T.6
  • 56
    • 33750940321 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC) [abstract]
    • Blumenschein GJ, Sandler A, O'Rourke T, Eschenberg M, Sun Y, Gladish G, et al. Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2006;s24:7119.
    • (2006) J Clin Oncol , vol.s24 , pp. 7119
    • Blumenschein, G.J.1    Sandler, A.2    O'Rourke, T.3    Eschenberg, M.4    Sun, Y.5    Gladish, G.6
  • 57
    • 78049392715 scopus 로고    scopus 로고
    • Randomized, open-label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC) [abstract]
    • Blumenschein GJ, Kabbinavar FF, Menon H, Mok T, Stephenson J, Beck JT, et al. Randomized, open-label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2010;s28:7528.
    • (2010) J Clin Oncol , vol.s28 , pp. 7528
    • Blumenschein, G.J.1    Kabbinavar, F.F.2    Menon, H.3    Mok, T.4    Stephenson, J.5    Beck, J.T.6
  • 59
    • 77955503066 scopus 로고    scopus 로고
    • Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage I/II resectable non-small cell lung cancer
    • Altorki N, Lane ME, Bauer T, Lee PC, Guarino MJ, Pass H, et al. Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage I/II resectable non-small cell lung cancer. J Clin Oncol 2010;28:3131-7.
    • (2010) J Clin Oncol , vol.28 , pp. 3131-3137
    • Altorki, N.1    Lane, M.E.2    Bauer, T.3    Lee, P.C.4    Guarino, M.J.5    Pass, H.6
  • 60
    • 74949090791 scopus 로고    scopus 로고
    • Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors
    • Mross K, Stefanic M, Gmehling D, Frost A, Baas F, Unger C, et al. Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors. Clin Cancer Res 2010;16:311-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 311-319
    • Mross, K.1    Stefanic, M.2    Gmehling, D.3    Frost, A.4    Baas, F.5    Unger, C.6
  • 62
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: biological actions
    • Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995;16:3-34.
    • (1995) Endocr Rev , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 63
    • 0033585421 scopus 로고    scopus 로고
    • Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis
    • Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X. Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis. J Natl Cancer Inst 1999;91:151-6.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 151-156
    • Yu, H.1    Spitz, M.R.2    Mistry, J.3    Gu, J.4    Hong, W.K.5    Wu, X.6
  • 64
    • 0036894939 scopus 로고    scopus 로고
    • Correlation between insulin-like growth factor-binding protein-3 promoter methylation and prognosis of patients with stage I non-small-cell lung cancer
    • Chang YS, Wang L, Liu D, Mao L, Hong WK, Khuri FR, et al. Correlation between insulin-like growth factor-binding protein-3 promoter methylation and prognosis of patients with stage I non-small-cell lung cancer. Clin Cancer Res 2002;8:3669-75.
    • (2002) Clin Cancer Res , vol.8 , pp. 3669-3675
    • Chang, Y.S.1    Wang, L.2    Liu, D.3    Mao, L.4    Hong, W.K.5    Khuri, F.R.6
  • 65
    • 77956165420 scopus 로고    scopus 로고
    • Safety and tolerability of the anti-IGF-I receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in patients with advanced solid tumors [abstract]
    • Pollak M, Eisenberg P, Karp D, Cohen R, Kreisman H, Adjei A, et al. Safety and tolerability of the anti-IGF-I receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in patients with advanced solid tumors [abstract]. American Association for Cancer Research Annual Meeting 2007:LB-343.
    • (2007) American Association for Cancer Research Annual Meeting
    • Pollak, M.1    Eisenberg, P.2    Karp, D.3    Cohen, R.4    Kreisman, H.5    Adjei, A.6
  • 66
    • 66349091290 scopus 로고    scopus 로고
    • Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced or metastatic non-small-cell lung cancer
    • Karp DD, Paz-Ares LG, Novello S, Haluska P, Garland L, Cardenal F, et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2009;27:2516-22
    • (2009) J Clin Oncol , vol.27 , pp. 2516-2522
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3    Haluska, P.4    Garland, L.5    Cardenal, F.6
  • 67
    • 33751076856 scopus 로고    scopus 로고
    • The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small-cell lung cancer
    • Han JY, Choi BG, Choi JY, Lee SY, Ju SY. The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small-cell lung cancer. Lung Cancer 2006;54:227-34.
    • (2006) Lung Cancer , vol.54 , pp. 227-234
    • Han, J.Y.1    Choi, B.G.2    Choi, J.Y.3    Lee, S.Y.4    Ju, S.Y.5
  • 68
    • 77956227862 scopus 로고    scopus 로고
    • Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small-cell lung cancer (NSCLC) [abstract]
    • Jassem C, Langer CJ, Karp DD, Mok T, Benner RJ, Green SJ, et al. Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small-cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2010;s28:7500.
    • (2010) J Clin Oncol , vol.s28 , pp. 7500
    • Jassem, C.1    Langer, C.J.2    Karp, D.D.3    Mok, T.4    Benner, R.J.5    Green, S.J.6
  • 70
    • 56149086171 scopus 로고    scopus 로고
    • A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors [abstract]
    • Atzori F, Tabernero J, Cervantes A, Botero M, Hsu K, Brown H, et al. A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors [abstract]. J Clin Oncol 2008:s26:3519.
    • (2008) J Clin Oncol , vol.s26 , pp. 3519
    • Atzori, F.1    Tabernero, J.2    Cervantes, A.3    Botero, M.4    Hsu, K.5    Brown, H.6
  • 71
    • 57149124243 scopus 로고    scopus 로고
    • A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF1R) in advanced solid tumor patients in a q2 wk schedule [abstract]
    • Hidalgo M, Tirado Gomez M, Lewis N, Vuky JL, Taylor G, Hayburn JL, et al. A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF1R) in advanced solid tumor patients in a q2 wk schedule [abstract]. J Clin Oncol 2008;s26:3520.
    • (2008) J Clin Oncol , vol.s26 , pp. 3520
    • Hidalgo, M.1    Tirado Gomez, M.2    Lewis, N.3    Vuky, J.L.4    Taylor, G.5    Hayburn, J.L.6
  • 73
    • 63849163410 scopus 로고    scopus 로고
    • Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
    • Cappuzzo F, Marchetti A, Skokan M, Rossi E, Gajapathy S, Felicioni L, et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol 2009;27:1667-74.
    • (2009) J Clin Oncol , vol.27 , pp. 1667-1674
    • Cappuzzo, F.1    Marchetti, A.2    Skokan, M.3    Rossi, E.4    Gajapathy, S.5    Felicioni, L.6
  • 74
    • 38049150665 scopus 로고    scopus 로고
    • MET amplifications occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. MET amplifications occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 2007;104:20932-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 75
    • 77957031745 scopus 로고    scopus 로고
    • Results from ARQ 197-209: A global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) [abstract]
    • Schiller JH, Akerley WL, Brugger W, Ferrari D, Garmey EG, Gerber DE, et al. Results from ARQ 197-209: A global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2010;s28:LBA7502.
    • (2010) J Clin Oncol , vol.s28
    • Schiller, J.H.1    Akerley, W.L.2    Brugger, W.3    Ferrari, D.4    Garmey, E.G.5    Gerber, D.E.6
  • 77
    • 0035064177 scopus 로고    scopus 로고
    • Ras biochemistry and farnesyl tranferase inhibitors: a literature survey
    • Crul M, de Klerk GJ, Beijnen JH, Schellens JH. Ras biochemistry and farnesyl tranferase inhibitors: a literature survey. Anticancer Drugs 2001;12:163-84.
    • (2001) Anticancer Drugs , vol.12 , pp. 163-184
    • Crul, M.1    de Klerk, G.J.2    Beijnen, J.H.3    Schellens, J.H.4
  • 78
    • 0036605562 scopus 로고    scopus 로고
    • Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer
    • Crul M, de Klerk GJ, Swart M, van't Veer LJ, de Jong D, Boerrigter L, et al. Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol 2002;20:2726-35.
    • (2002) J Clin Oncol , vol.20 , pp. 2726-2735
    • Crul, M.1    de Klerk, G.J.2    Swart, M.3    van't Veer, L.J.4    de Jong, D.5    Boerrigter, L.6
  • 79
    • 0035865305 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the oral farnesyl transferase inhibitor SCH 66336 given twice daily to patients with advanced solid tumors
    • Eskens FA, Awada A, Cutler DL, de Jonge MJ, Luyten GP, Faber MN, et al. Phase I and pharmacokinetic study of the oral farnesyl transferase inhibitor SCH 66336 given twice daily to patients with advanced solid tumors. J Clin Oncol 2001;19:1167-75.
    • (2001) J Clin Oncol , vol.19 , pp. 1167-1175
    • Eskens, F.A.1    Awada, A.2    Cutler, D.L.3    de Jonge, M.J.4    Luyten, G.P.5    Faber, M.N.6
  • 80
    • 0038362742 scopus 로고    scopus 로고
    • Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer (NSCLC)
    • Adjei AA, Mauer A, Bruzek L, Marks RS, Hillman S, Geyer S, et al. Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer (NSCLC). J Clin Oncol 2003;21:1760-6.
    • (2003) J Clin Oncol , vol.21 , pp. 1760-1766
    • Adjei, A.A.1    Mauer, A.2    Bruzek, L.3    Marks, R.S.4    Hillman, S.5    Geyer, S.6
  • 81
    • 22544467757 scopus 로고    scopus 로고
    • Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung cancer
    • Kim ES, Kies MS, Fossella FV, Glisson BS, Zaknoen S, Statkevich P, et al. Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung cancer. Cancer 2005;104:561-9.
    • (2005) Cancer , vol.104 , pp. 561-569
    • Kim, E.S.1    Kies, M.S.2    Fossella, F.V.3    Glisson, B.S.4    Zaknoen, S.5    Statkevich, P.6
  • 84
    • 8844222002 scopus 로고    scopus 로고
    • Frequent activation of AKT in non-small-cell lung carcinomas and preneoplastic bronchial lesions
    • Balsara BR, Pei J, Mitsuuchi Y, Page R, Klein-Szanto A, Wang H, et al. Frequent activation of AKT in non-small-cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis 2004;25:2053-9.
    • (2004) Carcinogenesis , vol.25 , pp. 2053-2059
    • Balsara, B.R.1    Pei, J.2    Mitsuuchi, Y.3    Page, R.4    Klein-Szanto, A.5    Wang, H.6
  • 86
    • 31344479312 scopus 로고    scopus 로고
    • Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
    • Tang JM, He QY, Guo RX, Chang XJ. Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer 2006;51:181-91.
    • (2006) Lung Cancer , vol.51 , pp. 181-191
    • Tang, J.M.1    He, Q.Y.2    Guo, R.X.3    Chang, X.J.4
  • 88
    • 58249120506 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the PX-866 whereas oncogenic Ras is a dominant predictor for resistance
    • Ihle NT, Lemos R Jr, Wipf P, Yacoub A, Mitchell C, Siwak D, et al. Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res 2009;69:143-50.
    • (2009) Cancer Res , vol.69 , pp. 143-150
    • Ihle, N.T.1    Lemos Jr., R.2    Wipf, P.3    Yacoub, A.4    Mitchell, C.5    Siwak, D.6
  • 89
    • 20244367301 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
    • Wislez M, Spencer ML, Izzo JG, Juroske DM, Balhara K, Cody DD, et al. Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res 2006;65:3226-35.
    • (2006) Cancer Res , vol.65 , pp. 3226-3235
    • Wislez, M.1    Spencer, M.L.2    Izzo, J.G.3    Juroske, D.M.4    Balhara, K.5    Cody, D.D.6
  • 90
    • 34247869651 scopus 로고    scopus 로고
    • Targeting mTOR signaling for lung cancer therapy
    • Sun SY, FU H Khuri FR. Targeting mTOR signaling for lung cancer therapy. J Thorac Oncol 2006;1:109-11.
    • (2006) J Thorac Oncol , vol.1 , pp. 109-111
    • Sun, S.Y.1    Fu, H.2    Khuri, F.R.3
  • 91
    • 33750321673 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer
    • Hidalgo M, Buckner JC, Erlichman C, Pollack MS, Boni JP, Dukart G, et al. A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer. Clin Cancer Res 2000;12:5755-63.
    • (2000) Clin Cancer Res , vol.12 , pp. 5755-5763
    • Hidalgo, M.1    Buckner, J.C.2    Erlichman, C.3    Pollack, M.S.4    Boni, J.P.5    Dukart, G.6
  • 92
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • Raymond E, Alexandre J, Faivre S, Vera K, Materman E, Boni J, et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004;22:2336-47.
    • (2004) J Clin Oncol , vol.22 , pp. 2336-2347
    • Raymond, E.1    Alexandre, J.2    Faivre, S.3    Vera, K.4    Materman, E.5    Boni, J.6
  • 93
    • 28844431555 scopus 로고    scopus 로고
    • A randomized, phase II ECOG trial of two dose levels of temsirolimus (CI-779) in patients with extensive stage small cell lung cancer in remission after induction chemotherapy. A preliminary report [abstract]
    • Pandya KJ, Levy DE, Hidalgo M, Cohen RB, Lee MW, Schiller JH, et al. A randomized, phase II ECOG trial of two dose levels of temsirolimus (CI-779) in patients with extensive stage small cell lung cancer in remission after induction chemotherapy. A preliminary report [abstract]. J Clin Oncol 2005;s23:7005.
    • (2005) J Clin Oncol , vol.s23 , pp. 7005
    • Pandya, K.J.1    Levy, D.E.2    Hidalgo, M.3    Cohen, R.B.4    Lee, M.W.5    Schiller, J.H.6
  • 94
    • 40349110085 scopus 로고    scopus 로고
    • A phase II NCCTG "window of opportunity front-line" study of the mTOR inhibitor CCI-779 (Temsirolimus) given as a single agent in patients with advanced NSCLC: D7-O7
    • Molina JR, Mandrekar SJ, Rowland K, Reuter NF, Jett JR, Marks R, et al. A phase II NCCTG "window of opportunity front-line" study of the mTOR inhibitor, CCI-779 (Temsirolimus) given as a single agent in patients with advanced NSCLC: D7-O7. J Thorac Oncol 2007;2:s413
    • (2007) J Thorac Oncol , vol.2
    • Molina, J.R.1    Mandrekar, S.J.2    Rowland, K.3    Reuter, N.F.4    Jett, J.R.5    Marks, R.6
  • 95
    • 8344221804 scopus 로고    scopus 로고
    • Results of a phase I clinical trial investigating a combination of the oral mTOR inhibitor everolimus (E, RAD001) and gemcitabine (GEM) in patients (pts) with advanced cancer [abstract]
    • Pacey S, Rea D, Steven N, Brock C, Knowlton N, Shand N, et al. Results of a phase I clinical trial investigating a combination of the oral mTOR inhibitor everolimus (E, RAD001) and gemcitabine (GEM) in patients (pts) with advanced cancer [abstract]. J Clin Oncol 2004;s22:3120.
    • (2004) J Clin Oncol , vol.s22 , pp. 3120
    • Pacey, S.1    Rea, D.2    Steven, N.3    Brock, C.4    Knowlton, N.5    Shand, N.6
  • 96
    • 70349637311 scopus 로고    scopus 로고
    • Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors
    • Soria JC, Shepherd FA, Douillard JY, Wolf J, Giaccone G, Crino L, et al. Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Ann Oncol 2009;20:1674-81.
    • (2009) Ann Oncol , vol.20 , pp. 1674-1681
    • Soria, J.C.1    Shepherd, F.A.2    Douillard, J.Y.3    Wolf, J.4    Giaccone, G.5    Crino, L.6
  • 97
    • 40349107679 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition by RAD001 in patients (pts) with recurrent non-small cell lung cancer (NSCLC): Use of 18F fluorodeoxyglucose positron-emission tomography (FDG-PET) in evaluation of the pharmacodynamic effect
    • Nogova L, Zander T, Gross SH, Pellas T, Hayes W, Thomas R, et al. Mammalian target of rapamycin (mTOR) inhibition by RAD001 in patients (pts) with recurrent non-small cell lung cancer (NSCLC): Use of 18F fluorodeoxyglucose positron-emission tomography (FDG-PET) in evaluation of the pharmacodynamic effect. J Thorac Oncol 2007;2:s583.
    • (2007) J Thorac Oncol , vol.2
    • Nogova, L.1    Zander, T.2    Gross, S.H.3    Pellas, T.4    Hayes, W.5    Thomas, R.6
  • 98
    • 17944368972 scopus 로고    scopus 로고
    • An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten +/- mice
    • Podsypanina K, Lee RT, Politis C, Hennessy I, Crane A, Puc J, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten +/- mice. Proc Natl Acad Sci USA 2001;98:10320-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10320-10325
    • Podsypanina, K.1    Lee, R.T.2    Politis, C.3    Hennessy, I.4    Crane, A.5    Puc, J.6
  • 99
    • 51449100587 scopus 로고    scopus 로고
    • Improved clinical and cell cycle response with an mTOR inhibitor, daily oral RAD001 (everolimus) plus letrozole versus placebo plus letrozole in a randomized phase II neoadjuvant trial in ER + breast cancer [abstract]
    • Baselga J, Van Dam PA, Greil R, Gardner H, Bandaru R, Molloy B, et al. Improved clinical and cell cycle response with an mTOR inhibitor, daily oral RAD001 (everolimus) plus letrozole versus placebo plus letrozole in a randomized phase II neoadjuvant trial in ER + breast cancer [abstract]. J Clin Oncol 2008;s26:530.
    • (2008) J Clin Oncol , vol.s26 , pp. 530
    • Baselga, J.1    Van Dam, P.A.2    Greil, R.3    Gardner, H.4    Bandaru, R.5    Molloy, B.6
  • 101
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • Bader AG, Kang S, Vogt PK. Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci USA 2006;103:1475-9.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 102
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-8.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3    Solit, D.4    Mills, G.B.5    Smith, D.6
  • 103
    • 0035964367 scopus 로고    scopus 로고
    • Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
    • Mills GB, Lu Y, Kohn EC. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci USA 2001;98:10031-3.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10031-10033
    • Mills, G.B.1    Lu, Y.2    Kohn, E.C.3
  • 104
  • 105
    • 77953291664 scopus 로고    scopus 로고
    • The biology and treatment of EML4-ALK non-small cell lung cancer
    • Sasaki T, Rodig SJ, Chirieac LR, Jänne PA. The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer 2010;46:1773-80.
    • (2010) Eur J Cancer , vol.46 , pp. 1773-1780
    • Sasaki, T.1    Rodig, S.J.2    Chirieac, L.R.3    Jänne, P.A.4
  • 106
    • 77954399760 scopus 로고    scopus 로고
    • Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression
    • Zhang X, Zhang S, Yang X, Yang J, Zhou Q, Yin L, et al. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer 2010;9:188.
    • (2010) Mol Cancer , vol.9 , pp. 188
    • Zhang, X.1    Zhang, S.2    Yang, X.3    Yang, J.4    Zhou, Q.5    Yin, L.6
  • 107
    • 70349510460 scopus 로고    scopus 로고
    • Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers
    • Lin E, Li L, Guan Y, Soriano R, Rivers CS, Mohan S, et al. Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. Mol Cancer Res 2009;7:1466-76.
    • (2009) Mol Cancer Res , vol.7 , pp. 1466-1476
    • Lin, E.1    Li, L.2    Guan, Y.3    Soriano, R.4    Rivers, C.S.5    Mohan, S.6
  • 109
    • 67649394729 scopus 로고    scopus 로고
    • Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
    • Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, et al. Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells. Cell Cycle 2009;8:1940-51.
    • (2009) Cell Cycle , vol.8 , pp. 1940-1951
    • Kazi, A.1    Lawrence, H.2    Guida, W.C.3    McLaughlin, M.L.4    Springett, G.M.5    Berndt, N.6
  • 111
    • 34247855046 scopus 로고    scopus 로고
    • Bortezomib (PS-341) in relapsed or refractory extensive stage small cell lung cancer: a Southwest Oncology Group phase II trial (S0327)
    • Lara PN Jr, Chansky K, Davies AM, Franklin WA, Gumerlock PH, Guaglianone PP, et al. Bortezomib (PS-341) in relapsed or refractory extensive stage small cell lung cancer: a Southwest Oncology Group phase II trial (S0327). J Thorac Oncol 2006;1:996-1001.
    • (2006) J Thorac Oncol , vol.1 , pp. 996-1001
    • Lara Jr., P.N.1    Chansky, K.2    Davies, A.M.3    Franklin, W.A.4    Gumerlock, P.H.5    Guaglianone, P.P.6
  • 112
    • 77649180963 scopus 로고    scopus 로고
    • Phase II study of the proteasome inhibitor bortezomib (PS-341 Velcade) in chemotherapy-naïve patients with advanced stage non-small cell lung cancer (NSCLC)
    • Li T, Ho L, Piperdi B, Elrafei T, Camacho FJ, Rigas JR, et al. Phase II study of the proteasome inhibitor bortezomib (PS-341, Velcade) in chemotherapy-naïve patients with advanced stage non-small cell lung cancer (NSCLC). Lung Cancer 2010;68:89-93.
    • (2010) Lung Cancer , vol.68 , pp. 89-93
    • Li, T.1    Ho, L.2    Piperdi, B.3    Elrafei, T.4    Camacho, F.J.5    Rigas, J.R.6
  • 113
    • 33750945704 scopus 로고    scopus 로고
    • Randomized phase II study of bortezomib alone and bortezomib in combination with docetaxel in previously treated advanced non-small-cell lung cancer
    • Fanucchi MP, Fossella FV, Belt R, Natale R, Fidias P, Carbone DP, et al. Randomized phase II study of bortezomib alone and bortezomib in combination with docetaxel in previously treated advanced non-small-cell lung cancer. J Clin Oncol 2006;24:5025-33.
    • (2006) J Clin Oncol , vol.24 , pp. 5025-5033
    • Fanucchi, M.P.1    Fossella, F.V.2    Belt, R.3    Natale, R.4    Fidias, P.5    Carbone, D.P.6
  • 114
    • 77952548567 scopus 로고    scopus 로고
    • A randomized phase II study of bortezomib and pemetrexed, in combination or alone, in patients with previously treated advanced non-small-cell lung cancer
    • Scagliotti GV, Germonpré P, Bosquée L, Vansteenkiste J, Gervais R, Planchard D, et al. A randomized phase II study of bortezomib and pemetrexed, in combination or alone, in patients with previously treated advanced non-small-cell lung cancer. Lung Cancer 2010;68:420-6.
    • (2010) Lung Cancer , vol.68 , pp. 420-426
    • Scagliotti, G.V.1    Germonpré, P.2    Bosquée, L.3    Vansteenkiste, J.4    Gervais, R.5    Planchard, D.6
  • 115
    • 61549138750 scopus 로고    scopus 로고
    • Bortezomib plus gemcitabine/carboplatin as first-line treatment of advanced non-small cell lung cancer: a phase II Southwest Oncology Group Study (S0339)
    • Davies AM, Chansky K, Lara PN Jr, Gumerlock PH, Crowley J, Albain KS, et al. Bortezomib plus gemcitabine/carboplatin as first-line treatment of advanced non-small cell lung cancer: a phase II Southwest Oncology Group Study (S0339). J Thorac Oncol 2009;4:87-92.
    • (2009) J Thorac Oncol , vol.4 , pp. 87-92
    • Davies, A.M.1    Chansky, K.2    Lara Jr., P.N.3    Gumerlock, P.H.4    Crowley, J.5    Albain, K.S.6
  • 116
    • 68349122406 scopus 로고    scopus 로고
    • A randomized phase 2 study of erlotinib alone and in combination with bortezomib in previously treated advanced non-small cell lung cancer
    • Lynch TJ, Fenton D, Hirsh V, Bodkin D, Middleman EL, Chiappori A, et al. A randomized phase 2 study of erlotinib alone and in combination with bortezomib in previously treated advanced non-small cell lung cancer. J Thorac Oncol 2009;4:1002-9.
    • (2009) J Thorac Oncol , vol.4 , pp. 1002-1009
    • Lynch, T.J.1    Fenton, D.2    Hirsh, V.3    Bodkin, D.4    Middleman, E.L.5    Chiappori, A.6
  • 117
    • 50349086621 scopus 로고    scopus 로고
    • The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer
    • Gridelli C, Rossi A, Maione P. The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer. Crit Rev Oncol Hematol 2008;68:29-36.
    • (2008) Crit Rev Oncol Hematol , vol.68 , pp. 29-36
    • Gridelli, C.1    Rossi, A.2    Maione, P.3
  • 118
    • 77956229982 scopus 로고    scopus 로고
    • Exciting new targets in lung cancer therapy: ALK, IGF-1R, HDAC, and Hh
    • Neal JW, Sequist LV. Exciting new targets in lung cancer therapy: ALK, IGF-1R, HDAC, and Hh. Curr Treat Options Oncol 2010;11:36-44.
    • (2010) Curr Treat Options Oncol , vol.11 , pp. 36-44
    • Neal, J.W.1    Sequist, L.V.2
  • 120
    • 16344391638 scopus 로고    scopus 로고
    • In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines
    • Loprevite M, Tiseo M, Grossi F, Scolaro T, Semino C, Pandolfi A, et al. In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines. Oncol Res 2005;15:39-48.
    • (2005) Oncol Res , vol.15 , pp. 39-48
    • Loprevite, M.1    Tiseo, M.2    Grossi, F.3    Scolaro, T.4    Semino, C.5    Pandolfi, A.6
  • 121
    • 67649399669 scopus 로고    scopus 로고
    • Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study
    • Traynor AM, Dubey S, Eickhoff JC, Kolesar JM, Schell K, Huie MS, et al. Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study. J Thorac Oncol 2009;4:522-6.
    • (2009) J Thorac Oncol , vol.4 , pp. 522-526
    • Traynor, A.M.1    Dubey, S.2    Eickhoff, J.C.3    Kolesar, J.M.4    Schell, K.5    Huie, M.S.6
  • 122
    • 34250696097 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies
    • Ramalingam SS, Parise RA, Ramanathan RK, Lagattuta TF, Musguire LA, Stoller RG, et al. Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies. Clin Cancer Res 2007;13:3605-10.
    • (2007) Clin Cancer Res , vol.13 , pp. 3605-3610
    • Ramalingam, S.S.1    Parise, R.A.2    Ramanathan, R.K.3    Lagattuta, T.F.4    Musguire, L.A.5    Stoller, R.G.6
  • 123
    • 73949140461 scopus 로고    scopus 로고
    • Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer
    • Ramalingam SS, Maitland ML, Frankel P, Argiris AE, Koczywas M, Gitlitz B, et al. Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. J Clin Oncol 2010;28:56-62.
    • (2010) J Clin Oncol , vol.28 , pp. 56-62
    • Ramalingam, S.S.1    Maitland, M.L.2    Frankel, P.3    Argiris, A.E.4    Koczywas, M.5    Gitlitz, B.6
  • 125
    • 84856559422 scopus 로고    scopus 로고
    • Phase I study of vorinostat (suberoylanilide hydroxamic acid NSC 701852) in combination with docetaxel in patients with advanced and relapsed solid malignancies
    • [Epub ahead of print] Aug 5
    • Schneider BJ, Kalemkerian GP, Bradley D, Smith DC, Egorin MJ, Daignault S, et al. Phase I study of vorinostat (suberoylanilide hydroxamic acid, NSC 701852) in combination with docetaxel in patients with advanced and relapsed solid malignancies. Invest New Drugs 2010 Aug 5. [Epub ahead of print].
    • (2010) Invest New Drugs
    • Schneider, B.J.1    Kalemkerian, G.P.2    Bradley, D.3    Smith, D.C.4    Egorin, M.J.5    Daignault, S.6
  • 126
    • 77958040418 scopus 로고    scopus 로고
    • Multi-gene expression-based predictors for sensitivity to Vorinostat and Velcade in non-small cell lung cancer
    • [Epub ahead of print] Aug 16
    • Nagji AS, Cho SH, Liu Y, Lee JK, Jones DR. Multi-gene expression-based predictors for sensitivity to Vorinostat and Velcade in non-small cell lung cancer. Mol Cancer Ther 2010 Aug 16. [Epub ahead of print].
    • (2010) Mol Cancer Ther
    • Nagji, A.S.1    Cho, S.H.2    Liu, Y.3    Lee, J.K.4    Jones, D.R.5
  • 127
    • 74749089384 scopus 로고    scopus 로고
    • Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features
    • Lee SM, Lee JY, Choi JE, Lee SY, Park JY, Kim DS. Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features. Cancer Genet Cytogenet 2010;197:39-45.
    • (2010) Cancer Genet Cytogenet , vol.197 , pp. 39-45
    • Lee, S.M.1    Lee, J.Y.2    Choi, J.E.3    Lee, S.Y.4    Park, J.Y.5    Kim, D.S.6
  • 128
    • 62549110421 scopus 로고    scopus 로고
    • Beyond doublet chemotherapy for advanced non-small-cell lung cancer: combination of targeted agents with first-line chemotherapy
    • Herbst RS, Lynch TJ, Sandler AB. Beyond doublet chemotherapy for advanced non-small-cell lung cancer: combination of targeted agents with first-line chemotherapy. Clin Lung Cancer 2009;10:20-7.
    • (2009) Clin Lung Cancer , vol.10 , pp. 20-27
    • Herbst, R.S.1    Lynch, T.J.2    Sandler, A.B.3
  • 130
    • 23844453749 scopus 로고    scopus 로고
    • Bexarotene in combination with chemotherapy fails to prolong survival in patients with advanced non-small-cell lung cancer: Results from the SPIRIT I and II trials
    • Tyagi P. Bexarotene in combination with chemotherapy fails to prolong survival in patients with advanced non-small-cell lung cancer: Results from the SPIRIT I and II trials. Clin Lung Cancer 2005;7:17-9.
    • (2005) Clin Lung Cancer , vol.7 , pp. 17-19
    • Tyagi, P.1
  • 132
    • 77955296228 scopus 로고    scopus 로고
    • Randomized phase II trial of All-trans-retinoic acid with chemotherapy based on paclitaxel and cisplatin as first-line treatment in patients with advanced non-small-cell lung cancer
    • Arrieta O, González-De la Rosa CH, Aréchaga-Ocampo E, Villanueva-Rodríguez G, Cerón-Lizárraga TL, Martínez-Barrera L, et al. Randomized phase II trial of All-trans-retinoic acid with chemotherapy based on paclitaxel and cisplatin as first-line treatment in patients with advanced non-small-cell lung cancer. J Clin Oncol 2010;28:3463-71.
    • (2010) J Clin Oncol , vol.28 , pp. 3463-3471
    • Arrieta, O.1    González-De la Rosa, C.H.2    Aréchaga-Ocampo, E.3    Villanueva-Rodríguez, G.4    Cerón-Lizárraga, T.L.5    Martínez-Barrera, L.6
  • 134
    • 24944448337 scopus 로고    scopus 로고
    • Phase II trial of the novel retinoid, bexarotene, and gemcitabine plus carboplatin in advanced non-small-cell lung cancer
    • Edelman MJ, Smith R, Hausner P, Doyle LA, Kalra K, Kendall J, et al. Phase II trial of the novel retinoid, bexarotene, and gemcitabine plus carboplatin in advanced non-small-cell lung cancer. J Clin Oncol 2005;23:5774-8.
    • (2005) J Clin Oncol , vol.23 , pp. 5774-5778
    • Edelman, M.J.1    Smith, R.2    Hausner, P.3    Doyle, L.A.4    Kalra, K.5    Kendall, J.6


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