Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 5057-5064

  Khidre, Rizk E ^a,b   Abu Hashem, Ameen A ^a,b   El Shazly, Mohamed ^c  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b JAZAN UNIVERSITY   (Saudi Arabia)

^c African Union Organization St Abbassia   (Egypt)

Author keywords

Anti microbial and antifungal activities; Hydrazide hydrazones; Pyridines; Structure activity relationship (SAR); Urea and thiourea derivatives

Indexed keywords

1 (1, 3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) 4,6 DIMETHYL 2 OXO 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 1 [(2 CHLORO 6 METHYL QUINOLIN 3 YLMETHYLENE) AMINO] 4,6 DIMETHYL 2 OXO 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 1 [(2 CHLORO QUINOLIN 3 YLMETHYLENE) AMINO] 4,6 DIMETHYL 2 OXO 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 1 [(3 BENZOFURAN 2 YL 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE) AMINO] 4,6 DIMETHYL 2 OXO 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 1 [(4 FLUORO BENZYLIDENE) AMINO] 4,6 DIMETHYL 2 OXO 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 1 [(5 CHLORO 3 METHYL 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE) AMINO] 4,6 DIMETHYL 2 OXO 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 1 [2 (3 CYANO 4,6 DIMETHYL 2 OXOPYRIDIN 1(2H) YLAMINO) 1 PHENYLVINYLAMINO] 4,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 1 [3 CYANO 4,6 DIMETHYL 2 OXO PYRIDIN 1(2H) YL] 3 PHENYLTHIOUREA; 1 [3 CYANO 4,6 DIMETHYL 2 OXOPYRIDIN 1(2H) YL] 3 PHENYLUREA; 3 AMINO N [3 CYANO 4,6 DIMETHYL 2 OXOPYRIDIN 1(2H) YL] 4 (4 METHOXYPHENYL) 6 (THIOPHEN 2 YL)THIENO[2,3 B]PYRIDINE 2 CARBOXAMIDE; 4 (BENZOFURAN 2 YL) N (3 CYANO 4,6 DIMETHYL 2 OXOPYRIDIN 1(2H) YL) 2,4 DIOXOBUTANAMIDE; 4,6 DIMETHYL 2 OXO 1 (4,5,6,7 TETRABROMO 1,3 DIOXOISOINDOLIN 2 YL) 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 4,6 DIMETHYL 2 OXO 1 [(1,2,3,4 TETRAZOLO[1,5 A]QUINOLIN 6 YLMETHYLENE) AMINO] 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 4,6 DIMETHYL 2 OXO 1 [(9 METHYL 1,2,3,4 TETRAZOLO[1,5 A]QUINOLIN 6 YLMETHYLENE) AMINO] 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 4,6 DIMETHYL 2 OXO 1 [(THIOPHEN 2 YLMETHYLENE) AMINO] 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; CLOTRIMAZOLE; HYDRAZIDE DERIVATIVE; HYDRAZONE DERIVATIVE; ITRACONAZOLE; PENICILLIN G; PHTHALIMIDE DERIVATIVE; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACILLUS SUBTILIS; BIOLOGICAL ACTIVITY; CANDIDA ALBICANS; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; GALACTOMYCES GEOTRICHUM; INFRARED SPECTROMETRY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; FUNGI; HUMANS; HYDRAZONES; MICROBIAL SENSITIVITY TESTS; MYCOSES; NITRILES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053178686     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.018     Document Type: Article

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