New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1- acylhydrazone derivatives

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 12, 2004, Pages 3149-3158

  Silva, Gildásio A ^a   Costa, Luciana M M ^a   Brito, Fernanda C F ^a   Miranda, Ana L P ^a   Barreiro, Eliezer J ^a   Fraga, Carlos A M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

10H phenothiazine; Acylhydrazone derivatives; Analgesic activity; Antiplatelet drugs; Molecular hybridization

Indexed keywords

(3',5' DI TERT BUTYL 4' HYDROXYBENZYLIDENE) 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; (4' BROMOBENZYLIDENE) 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; (4' CARBOXYBENZYLIDENE) 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; (4' DIMETHYLAMINOBENZYLIDENE) 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; (4' METHOXYBENZYLIDENE) 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; (4' NITROBENZYLIDENE) 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; (FURFURYLIDENE) 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; (THIENYLIDENE) 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; BENZYLIDENE 10H PHENOTHIAZINE 1 CARBOHYDRAZIDE; BROMINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CHLORPROMAZINE; DIPHENYLAMINE; DIPYRONE; HETEROCYCLIC COMPOUND; HYDRAZONE DERIVATIVE; INDOMETACIN; PHENOTHIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; FEMALE; HUMAN; MALE; MOLECULAR HYBRIDIZATION; MOUSE; NONHUMAN; THROMBOCYTE AGGREGATION INHIBITION;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DRUG DESIGN; HUMANS; HYDRAZONES; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS; RATS; THIAZINES;

EID: 2542432180     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.009     Document Type: Article

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