Synthesis of some new pyrimido[2′,1′:2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1976-1981

  Abu Hashem, A A ^a   Gouda, M A ^b   Badria, F A ^c  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b Mansoura University   (Egypt)

^c MANSOURA UNIVERSITY   (Egypt)

Author keywords

2,3 Dichloroquinoxaline; 6 Amino 2 mercaptopyrimidin 4(3H) one; Analgesic activities; Anti inflammatory activities; Pyrimido 2 ,1 :2,3 thiazolo 4,5 b quinoxaline

Indexed keywords

2 [ 4 (PYRIDINYLMETHYLENE)IMINO] 2 AMINOPYRIMIDO[ 20,10:2,3 ] THIAZOLO[ 4,5 B]QUINOXALINE 4 ONE; 2 AMINOPYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE 4 ONE; 3 ( 4 CHLOROBENZYLIDENE) 7 ( 4 CHLOROPHENYL) 3,4,5,6 TETRAHYDROQUINOLINO[ 200,300:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5B]QUINOXALINE 8 ONE; 3 ( 4 METHOXYBENZYLIDENE) 7 ( 4 METHOXYPHENYL) 3,4,5,6 TETRAHYDROQUINOLINO[ 200,300:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE 8 ONE; 3 BENZYLIDENE 7 PHENYL 3,4,5,6 TETRAHYDROQUINOLINO[ 200,300:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE 8 ONE; 3,4,5,6 TETRAHYDROQUINOLINO[ 200,300:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5-B]QUINOXALINE 8 ONE; 4 CHLORO QUINOLINO[ 200,300:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5B]QUINOXALINE 7( 2H) 8 DIONE; 5 METHYL 3 PHENYL 3H PYRAZOLO[ 30,40:200,300 ]PYRIDO[ 500,600:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE 7 ONE; 6 AMINO 2 ( 3 CHLOROQUINOXALIN 2 YLTHIO)PYRIMIDIN 4 (3H)ONE; 7 AMINO 4,6 DIMETHYL 1,8 NAPHTHYRIDINO[ 200,300:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE 8 ONE; DICLOFENAC; PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE; PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE 8 ONE; QUINOLINO[ 200,300:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE 7 ( 2H) 8 DIONE; QUINOLINO[ 200,300:40,50 ]PYRIMIDO[ 20,10:2,3 ]THIAZOLO[ 4,5 B]QUINOXALINE 8 ONE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; HOT PLATE TEST; INFRARED RADIATION; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PAIN; PAW EDEMA; RAT;

ACETIC ACID; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DRUG EVALUATION, PRECLINICAL; EDEMA; FEMALE; MALE; MICE; MOLECULAR STRUCTURE; PAIN; PAIN MEASUREMENT; PYRIMIDINES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; THIAZOLES;

EID: 77949485942     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.042     Document Type: Article

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