A new modification of anti-tubercular active molecules

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 7, 2007, Pages 2551-2559

  Imramovský, Aleš ^a,b   Polanc, Slovenko ^b   Vinšová, Jarmila ^a   Kočevar, Marijan ^b   Jampílek, Josef ^c   Rečková, Zuzana ^c   Kaustová, Jarmila ^d  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c Zentiva Prague   (Czech Republic)

^d Regional Institute of Hygiene   (Czech Republic)

Author keywords

In vitro antituberculosis activity; Isoniazid; Lipophilicity determination; Pyrazinamide

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 4 OXO 7 [[4 (PYRAZIN 2 YL CARBONYL)IMINOMETHYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 4 OXO 7 [[4 (PYRAZIN 2 YLCARBONYL)IMINOMETHYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 7 [4 [(ISONICOTINOYLHYDRAZONO)METHYL]PIPERAZIN 1 YL] 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1,3 BIS(1 HYDROXYBUTAN 2 YL)IMIDAZOLIDIN 2 YL 4 METHYLBENZENE SULFONATE; 2 HYDROXY 4 [[(ISONICOTINOYLHYDRAZONO)METHYL]AMINO]BENZOIC ACID; 4 (2 PYRAZINECARBONYLIMINOMETHYL)AMINOSALICYLIC ACID; AMINOSALICYLIC ACID; AMINOSALICYLIC ACID DERIVATIVE; CIPROFLOXACIN; CIPROFLOXACIN DERIVATIVE; ETHAMBUTOL DERIVATIVE; ISONIAZID; ISONIAZID DERIVATIVE; N (DIMETHYLAMINOMETHYLENE)PYRAZINE 2 CARBOXAMIDE; N [(2 ISONICOTINOYLHYDRAZINO)METHYLIDENE] 2 PYRAZINE CARBOXAMIDE; N BENZYL N' ISONICOTINOYLHYDRAZONOFORMAMIDE; N ISONICOTINOYL N (PYRIDIN 2 YLMETHYL)HYDRAZONOFORMAMIDE; N' (MORPHOLIN 4 YLMETHYLENE)ISONICOTINOHYDRAZIDE; N' ISONICOTINOYL N,N DIMETHYLHYDRAZONOFORMAMIDE; N',N'' DIISONICOTINOYLHYDRAZONOFORMIC HYDRAZIDE; PYRAZINAMIDE; PYRAZINAMIDE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG HYDROLYSIS; DRUG STABILITY; DRUG SYNTHESIS; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTITUBERCULAR AGENTS; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HALF-LIFE; ISONIAZID; KINETICS; LIPIDS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; PYRAZINAMIDE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847664296     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.051     Document Type: Article

References (25)

1. http://www.who.int/mediacentre/events/2006/world.tb.day/en/index.html (May 2006).
2. Duncan K. Curr. Opin. Microbiol. 7 (2004) 460
3. Nayyar A., and Jain R. Curr. Med. Chem. 12 (2005) 1873
4. Zhang Y., Post-Martens K., and Denkin S. Drug Discovery Today 11 (2006) 21
5. Zhang Y., and Amzel L.M. Curr. Drug Targets 3 (2002) 131
6. Sriram D., Yogeeswari P., and Reddy S.P. Bioorg. Med. Chem. Lett. 16 (2006) 2113
7. Sriram D., Yogeeswari P., and Madhu K. Bioorg. Med. Chem. Lett. 15 (2005) 4502
8. Glushkov R.G., Modnikova G.A., Lvov A.I., Krylova L.Yu., Pushkina T.V., Gus'kova T.A., and Soloveva N.P. Khim.-Farm. Zh. 38 (2004) 420
9. Sinha N., Jain S., Tilekar A., Upadhayaya R.S., Kishore N., Jana G.H., and Arora S.K. Bioorg. Med. Chem. Lett. 15 (2005) 1573
10. Marrakchi H., Laneelle G., and Quemard A. Microbiology 146 (2000) 296
11. Zhang Y., Wade M.M., Scorpio A., Zhang H., and Sun Z.H. J. Antimicrob. Chemother. 52 (2003) 790
12. DeLogu A., Onnis V., Saddi B., Congiu C., Schivo M.L., and Cocco M.T. J. Antimicrob. Chemother. 49 (2002) 275
13. Košmrlj B., Koklič B., and Polanc S. Acta Chim. Slov. 43 (1996) 153
14. Kočevar M., Mihorko P., and Polanc S. Synlett (1995) 241
15. Kočevar M., Mihorko P., and Polanc S. Synthesis (1993) 773
16. Doležal M., Palek L., Vinšová J., Buchta V., Jampílek J., and Králová K. Molecules 11 (2006) 242
17. Teng X.W., Cutler D.C., and Davies N.M. Int. J. Pharm. 259 (2003) 129
18. van Dijk-Wolthuis W.N.E., van Steenbergen M.J., Underberg W.J.M., and Hennink W.E. J. Pharm. Sci. 86 (1997) 413
19. Archontaki H.A., Panderi I.E., Gikas E.E., and Parissi-Poulou M. J. Pharm. Biomed. Anal. 17 (1998) 739
20. Yeh M.K. Drug Dev. Ind. Pharm. 26 (2000) 1221
21. Liang J., Bruell C.J., Marley M.C., and Sperry K.L. Soil Sediment Contam. 12 (2003) 207
22. Fedorova, N. D.; Dolgorev, A. V.; Onorina, I. A. SU Patent 1226202, 1986; Chem. Abstr. 1986, 105, 71795.
23. Fr Patent 1412506, 1967; Chem. Abstr. 1967, 67, 62998.
24. Runti C., Sindellari L., and Nisi C. Ann. Chim. (Rome) 49 (1959) 1649
25. Collins L.A., and Franzblau S.G. Antimicrob. Agents Chemother. 41 (1997) 1004