메뉴 건너뛰기




Volumn 141, Issue 1, 2011, Pages 15-30

HIV controllers: A multifactorial phenotype of spontaneous viral suppression

Author keywords

CD4 T cell; Controllers; HIV; Long term non progressors; Pathogenesis; Protective immunity

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

EID: 80053132664     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2011.07.007     Document Type: Review
Times cited : (41)

References (133)
  • 1
    • 34548689151 scopus 로고    scopus 로고
    • Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy
    • Deeks S.G., Walker B.D. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity 2007, 27:406-416.
    • (2007) Immunity , vol.27 , pp. 406-416
    • Deeks, S.G.1    Walker, B.D.2
  • 27
  • 34
    • 79955479979 scopus 로고    scopus 로고
    • Natural killer cells in spontaneous control of HIV infection
    • Berger C.T., Alter G. Natural killer cells in spontaneous control of HIV infection. Curr. Opin. HIV AIDS 2011, 6:208-213.
    • (2011) Curr. Opin. HIV AIDS , vol.6 , pp. 208-213
    • Berger, C.T.1    Alter, G.2
  • 37
    • 77950210095 scopus 로고    scopus 로고
    • Specific phenotypic and functional features of natural killer cells from HIV-infected long-term nonprogressors and HIV controllers
    • Vieillard V., Fausther-Bovendo H., Samri A., Debre P. Specific phenotypic and functional features of natural killer cells from HIV-infected long-term nonprogressors and HIV controllers. J. Acquir. Immune Defic. Syndr. 2010, 53:564-573.
    • (2010) J. Acquir. Immune Defic. Syndr. , vol.53 , pp. 564-573
    • Vieillard, V.1    Fausther-Bovendo, H.2    Samri, A.3    Debre, P.4
  • 39
    • 30944452875 scopus 로고    scopus 로고
    • Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapy
    • Schmidt B., Fujimura S.H., Martin J.N., Levy J.A. Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapy. J. Clin. Immunol. 2006, 26:55-64.
    • (2006) J. Clin. Immunol. , vol.26 , pp. 55-64
    • Schmidt, B.1    Fujimura, S.H.2    Martin, J.N.3    Levy, J.A.4
  • 41
    • 77956033397 scopus 로고    scopus 로고
    • Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers
    • Huang J., Burke P.S., Cung T.D., Pereyra F., Toth I., Walker B.D., Borges L., Lichterfeld M., Yu X.G. Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J. Virol. 2010, 84:9463-9471.
    • (2010) J. Virol. , vol.84 , pp. 9463-9471
    • Huang, J.1    Burke, P.S.2    Cung, T.D.3    Pereyra, F.4    Toth, I.5    Walker, B.D.6    Borges, L.7    Lichterfeld, M.8    Yu, X.G.9
  • 42
    • 67649660551 scopus 로고    scopus 로고
    • Redefining chronic viral infection
    • Virgin H.W., Wherry E.J., Ahmed R. Redefining chronic viral infection. Cell 2009, 138:30-50.
    • (2009) Cell , vol.138 , pp. 30-50
    • Virgin, H.W.1    Wherry, E.J.2    Ahmed, R.3
  • 43
    • 70849099812 scopus 로고    scopus 로고
    • CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help
    • Nakanishi Y., Lu B., Gerard C., Iwasaki A. CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature 2009, 462:510-513.
    • (2009) Nature , vol.462 , pp. 510-513
    • Nakanishi, Y.1    Lu, B.2    Gerard, C.3    Iwasaki, A.4
  • 45
    • 41549131849 scopus 로고    scopus 로고
    • T follicular helper (TFH) cells in normal and dysregulated immune responses
    • King C., Tangye S.G., Mackay C.R. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 2008, 26:741-766.
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 741-766
    • King, C.1    Tangye, S.G.2    Mackay, C.R.3
  • 46
    • 0035912232 scopus 로고    scopus 로고
    • The dynamics of CD4+ T-cell depletion in HIV disease
    • McCune J.M. The dynamics of CD4+ T-cell depletion in HIV disease. Nature 2001, 410:974-979.
    • (2001) Nature , vol.410 , pp. 974-979
    • McCune, J.M.1
  • 48
    • 0347911962 scopus 로고    scopus 로고
    • HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity
    • Younes S.A., Yassine-Diab B., Dumont A.R., Boulassel M.R., Grossman Z., Routy J.P., Sekaly R.P. HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J. Exp. Med. 2003, 198:1909-1922.
    • (2003) J. Exp. Med. , vol.198 , pp. 1909-1922
    • Younes, S.A.1    Yassine-Diab, B.2    Dumont, A.R.3    Boulassel, M.R.4    Grossman, Z.5    Routy, J.P.6    Sekaly, R.P.7
  • 49
    • 27644489746 scopus 로고    scopus 로고
    • Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
    • Emu B., Sinclair E., Favre D., Moretto W.J., Hsue P., Hoh R., Martin J.N., Nixon D.F., McCune J.M., Deeks S.G. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J. Virol. 2005, 79:14169-14178.
    • (2005) J. Virol. , vol.79 , pp. 14169-14178
    • Emu, B.1    Sinclair, E.2    Favre, D.3    Moretto, W.J.4    Hsue, P.5    Hoh, R.6    Martin, J.N.7    Nixon, D.F.8    McCune, J.M.9    Deeks, S.G.10
  • 52
    • 0037340455 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2-induced Jak/STAT signalling in human CD4 T lymphocytes
    • Kryworuchko M., Pasquier V., Theze J. Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2-induced Jak/STAT signalling in human CD4 T lymphocytes. Clin. Exp. Immunol. 2003, 131:422-427.
    • (2003) Clin. Exp. Immunol. , vol.131 , pp. 422-427
    • Kryworuchko, M.1    Pasquier, V.2    Theze, J.3
  • 56
    • 72849135730 scopus 로고    scopus 로고
    • Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway
    • Juffroy O., Bugault F., Lambotte O., Landires I., Viard J.P., Niel L., Fontanet A., Delfraissy J.F., Theze J., Chakrabarti L.A. Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. J. Virol. 2010, 84:96-108.
    • (2010) J. Virol. , vol.84 , pp. 96-108
    • Juffroy, O.1    Bugault, F.2    Lambotte, O.3    Landires, I.4    Viard, J.P.5    Niel, L.6    Fontanet, A.7    Delfraissy, J.F.8    Theze, J.9    Chakrabarti, L.A.10
  • 57
    • 77957374578 scopus 로고    scopus 로고
    • Interleukin-7 in HIV pathogenesis and therapy
    • Chahroudi A., Silvestri G. Interleukin-7 in HIV pathogenesis and therapy. Eur. Cytokine Netw. 2010, 21:202-207.
    • (2010) Eur. Cytokine Netw. , vol.21 , pp. 202-207
    • Chahroudi, A.1    Silvestri, G.2
  • 63
    • 79955476141 scopus 로고    scopus 로고
    • HIV-specific CD4 T cells and immune control of viral replication
    • Porichis F., Kaufmann D.E. HIV-specific CD4 T cells and immune control of viral replication. Curr. Opin. HIV AIDS 2011, 6:174-180.
    • (2011) Curr. Opin. HIV AIDS , vol.6 , pp. 174-180
    • Porichis, F.1    Kaufmann, D.E.2
  • 64
    • 0035198096 scopus 로고    scopus 로고
    • Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection
    • Betts M.R., Ambrozak D.R., Douek D.C., Bonhoeffer S., Brenchley J.M., Casazza J.P., Koup R.A., Picker L.J. Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection. J. Virol. 2001, 75:11983-11991.
    • (2001) J. Virol. , vol.75 , pp. 11983-11991
    • Betts, M.R.1    Ambrozak, D.R.2    Douek, D.C.3    Bonhoeffer, S.4    Brenchley, J.M.5    Casazza, J.P.6    Koup, R.A.7    Picker, L.J.8
  • 65
    • 1642500367 scopus 로고    scopus 로고
    • Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy
    • Harari A., Petitpierre S., Vallelian F., Pantaleo G. Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy. Blood 2004, 103:966-972.
    • (2004) Blood , vol.103 , pp. 966-972
    • Harari, A.1    Petitpierre, S.2    Vallelian, F.3    Pantaleo, G.4
  • 66
    • 78649881447 scopus 로고    scopus 로고
    • Interleukin-21: a multifunctional regulator of immunity to infections
    • Yi J.S., Cox M.A., Zajac A.J. Interleukin-21: a multifunctional regulator of immunity to infections. Microbes Infect. 2010, 12:1111-1119.
    • (2010) Microbes Infect. , vol.12 , pp. 1111-1119
    • Yi, J.S.1    Cox, M.A.2    Zajac, A.J.3
  • 67
    • 51849116934 scopus 로고    scopus 로고
    • Decreased levels of circulating IL-21 in HIV-infected AIDS patients: correlation with CD4+ T-cell counts
    • Iannello A., Tremblay C., Routy J.P., Boulassel M.R., Toma E., Ahmad A. Decreased levels of circulating IL-21 in HIV-infected AIDS patients: correlation with CD4+ T-cell counts. Viral Immunol. 2008, 21:385-388.
    • (2008) Viral Immunol. , vol.21 , pp. 385-388
    • Iannello, A.1    Tremblay, C.2    Routy, J.P.3    Boulassel, M.R.4    Toma, E.5    Ahmad, A.6
  • 68
    • 73949110184 scopus 로고    scopus 로고
    • Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study
    • Iannello A., Boulassel M.R., Samarani S., Debbeche O., Tremblay C., Toma E., Routy J.P., Ahmad A. Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study. J. Immunol. 2010, 184:114-126.
    • (2010) J. Immunol. , vol.184 , pp. 114-126
    • Iannello, A.1    Boulassel, M.R.2    Samarani, S.3    Debbeche, O.4    Tremblay, C.5    Toma, E.6    Routy, J.P.7    Ahmad, A.8
  • 75
    • 34548637484 scopus 로고    scopus 로고
    • Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction
    • D'Souza M., Fontenot A.P., Mack D.G., Lozupone C., Dillon S., Meditz A., Wilson C.C., Connick E., Palmer B.E. Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction. J. Immunol. 2007, 179:1979-1987.
    • (2007) J. Immunol. , vol.179 , pp. 1979-1987
    • D'Souza, M.1    Fontenot, A.P.2    Mack, D.G.3    Lozupone, C.4    Dillon, S.5    Meditz, A.6    Wilson, C.C.7    Connick, E.8    Palmer, B.E.9
  • 78
    • 70350743827 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention
    • Kaufmann D.E., Walker B.D. PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention. J. Immunol. 2009, 182:5891-5897.
    • (2009) J. Immunol. , vol.182 , pp. 5891-5897
    • Kaufmann, D.E.1    Walker, B.D.2
  • 79
    • 77957369615 scopus 로고    scopus 로고
    • Protective and detrimental roles of IL-10 in HIV pathogenesis
    • Kwon D.S., Kaufmann D.E. Protective and detrimental roles of IL-10 in HIV pathogenesis. Eur. Cytokine Netw. 2010, 21:208-214.
    • (2010) Eur. Cytokine Netw. , vol.21 , pp. 208-214
    • Kwon, D.S.1    Kaufmann, D.E.2
  • 83
    • 77954015445 scopus 로고    scopus 로고
    • Duality in the Th17-Treg developmental decision
    • (F1000)
    • Hatton R.D., Weaver C.T. Duality in the Th17-Treg developmental decision. Biol. Reprod. 2009, 1. (F1000).
    • (2009) Biol. Reprod. , vol.1
    • Hatton, R.D.1    Weaver, C.T.2
  • 90
    • 79957940672 scopus 로고    scopus 로고
    • Low level of regulatory T-cells and maintenance of balance between regulatory T-cells and TH17 cells in HIV-1-infected elite controllers
    • Brandt L., Benfield T., Mens H., Clausen L.N., Katzenstein T.L., Fomsgaard A., Karlsson I. Low level of regulatory T-cells and maintenance of balance between regulatory T-cells and TH17 cells in HIV-1-infected elite controllers. J. Acquir. Immune Defic. Syndr. 2011, 57:101-108.
    • (2011) J. Acquir. Immune Defic. Syndr. , vol.57 , pp. 101-108
    • Brandt, L.1    Benfield, T.2    Mens, H.3    Clausen, L.N.4    Katzenstein, T.L.5    Fomsgaard, A.6    Karlsson, I.7
  • 96
    • 63149122367 scopus 로고    scopus 로고
    • Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure
    • Harari A., Enders F.B., Cellerai C., Bart P.A., Pantaleo G. Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure. J. Virol. 2009, 83:2862-2871.
    • (2009) J. Virol. , vol.83 , pp. 2862-2871
    • Harari, A.1    Enders, F.B.2    Cellerai, C.3    Bart, P.A.4    Pantaleo, G.5
  • 104
    • 78349304870 scopus 로고    scopus 로고
    • Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes
    • Bennett M.S., Joseph A., Ng H.L., Goldstein H., Yang O.O. Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes. AIDS 2010, 24:2619-2628.
    • (2010) AIDS , vol.24 , pp. 2619-2628
    • Bennett, M.S.1    Joseph, A.2    Ng, H.L.3    Goldstein, H.4    Yang, O.O.5
  • 109
    • 33646453478 scopus 로고    scopus 로고
    • Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy
    • Bailey J.R., Lassen K.G., Yang H.C., Quinn T.C., Ray S.C., Blankson J.N., Siliciano R.F. Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy. J. Virol. 2006, 80:4758-4770.
    • (2006) J. Virol. , vol.80 , pp. 4758-4770
    • Bailey, J.R.1    Lassen, K.G.2    Yang, H.C.3    Quinn, T.C.4    Ray, S.C.5    Blankson, J.N.6    Siliciano, R.F.7
  • 113
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    • Mattapallil J.J., Douek D.C., Hill B., Nishimura Y., Martin M., Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 2005, 434:1093-1097.
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3    Nishimura, Y.4    Martin, M.5    Roederer, M.6
  • 115
    • 4644289983 scopus 로고    scopus 로고
    • Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    • Mehandru S., Poles M.A., Tenner-Racz K., Horowitz A., Hurley A., Hogan C., Boden D., Racz P., Markowitz M. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J. Exp. Med. 2004, 200:761-770.
    • (2004) J. Exp. Med. , vol.200 , pp. 761-770
    • Mehandru, S.1    Poles, M.A.2    Tenner-Racz, K.3    Horowitz, A.4    Hurley, A.5    Hogan, C.6    Boden, D.7    Racz, P.8    Markowitz, M.9
  • 117
    • 22244451393 scopus 로고    scopus 로고
    • Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors
    • Sankaran S., Guadalupe M., Reay E., George M.D., Flamm J., Prindiville T., Dandekar S. Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors. Proc. Natl. Acad. Sci. USA 2005, 102:9860-9865.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 9860-9865
    • Sankaran, S.1    Guadalupe, M.2    Reay, E.3    George, M.D.4    Flamm, J.5    Prindiville, T.6    Dandekar, S.7
  • 118
    • 77956793480 scopus 로고    scopus 로고
    • Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers
    • Ferre A.L., Lemongello D., Hunt P.W., Morris M.M., Garcia J.C., Pollard R.B., Yee H.F., Martin J.N., Deeks S.G., Shacklett B.L. Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers. J. Virol. 2010, 84:10354-10365.
    • (2010) J. Virol. , vol.84 , pp. 10354-10365
    • Ferre, A.L.1    Lemongello, D.2    Hunt, P.W.3    Morris, M.M.4    Garcia, J.C.5    Pollard, R.B.6    Yee, H.F.7    Martin, J.N.8    Deeks, S.G.9    Shacklett, B.L.10
  • 121
    • 67651125105 scopus 로고    scopus 로고
    • Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis
    • Hsue P.Y., Hunt P.W., Schnell A., Kalapus S.C., Hoh R., Ganz P., Martin J.N., Deeks S.G. Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis. AIDS 2009, 23:1059-1067.
    • (2009) AIDS , vol.23 , pp. 1059-1067
    • Hsue, P.Y.1    Hunt, P.W.2    Schnell, A.3    Kalapus, S.C.4    Hoh, R.5    Ganz, P.6    Martin, J.N.7    Deeks, S.G.8
  • 125
    • 77953901782 scopus 로고    scopus 로고
    • Nonprogressive and progressive primate immunodeficiency lentivirus infections
    • Brenchley J.M., Silvestri G., Douek D.C. Nonprogressive and progressive primate immunodeficiency lentivirus infections. Immunity 2010, 32:737-742.
    • (2010) Immunity , vol.32 , pp. 737-742
    • Brenchley, J.M.1    Silvestri, G.2    Douek, D.C.3
  • 126
    • 79955463139 scopus 로고    scopus 로고
    • Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses
    • Mudd P.A., Watkins D.I. Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses. Curr. Opin. HIV AIDS 2011, 6:197-201.
    • (2011) Curr. Opin. HIV AIDS , vol.6 , pp. 197-201
    • Mudd, P.A.1    Watkins, D.I.2
  • 131
    • 78650598765 scopus 로고    scopus 로고
    • The quest for a T cell-based immune correlate of protection against HIV: a story of trials and errors
    • Koup R.A., Graham B.S., Douek D.C. The quest for a T cell-based immune correlate of protection against HIV: a story of trials and errors. Nat. Rev. Immunol. 2011, 11:65-70.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 65-70
    • Koup, R.A.1    Graham, B.S.2    Douek, D.C.3
  • 132
    • 78049423723 scopus 로고    scopus 로고
    • Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations
    • Horton R.E., McLaren P.J., Fowke K., Kimani J., Ball T.B. Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations. J. Infect. Dis. 2010, 202(Suppl. 3):S377-381.
    • (2010) J. Infect. Dis. , vol.202 , Issue.SUPPL. 3
    • Horton, R.E.1    McLaren, P.J.2    Fowke, K.3    Kimani, J.4    Ball, T.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.