HIV controllers: A homogeneous group of HIV-1-infected patients with spontaneous control of viral replication

Clinical Infectious Diseases

Volumn 41, Issue 7, 2005, Pages 1053-1056

  Lambotte, Olivier ^a,c   Boufassa, Faroudy ^b   Madec, Yoann ^b   Nguyen, Ahn ^c   Goujard, Cécile ^c   Meyer, Laurence ^b   Rouzioux, Christine ^d   Venet, Alain ^a   Oelfraissy, Jean François ^a,c  

^a INSERM   (France)

^b INSTITUT NATIONAL D'ÉTUDES DÉMOGRAPHIQUES   (France)

^c BICÊTRE HOSPITAL   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; HLA ANTIGEN CLASS 1; VIRUS RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INFECTION CONTROL; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS LOAD; VIRUS REPLICATION;

ADULT; AGED; CD8-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; RNA, VIRAL; TIME FACTORS; VIRAL LOAD; VIRUS REPLICATION;

EID: 25444471257     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/433188     Document Type: Article

References (18)

1. Hogan CM, Hammer SM. Host determinants in HIV infection and disease. Ann Intern Med 2001; 134:761-76.
2. Migueles SA, Sabbaghian MS, Shupert WL, et al. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci U S A 2000; 97:2709-14.
3. Cao Y, Qin L, Zhang L, Safrit J, Ho DD. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med 1995; 332:201-8.
4. Greenough TC, Brettler DB, Kirchhoff F, et al. Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort. J Infect Dis 1999; 180:1790-802.
5. + T cell proliferation is coupled to perform expression and is maintained in nonprogressors. Nat Immunol 2002; 3:1061-8.
6. Lefrere JJ, Morand-Joubert L, Mariotti M, et al. Even individuals considered as long-term nonprogressors show biological signs of progression after 10 years of human immunodeficiency virus infection. Blood 1997; 90:1133-40.
7. Strathdee SA, Veugelers PJ, Page-Shafer KA, et al. Lack of consistency between five definitions of nonprogression in cohorts of HIV-infected seroconverters. AIDS 1996; 10:959-65.
8. Flores-Villanueva PO, Yunis EJ, Delgado JC, et al. Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. Proc Natl Acad Sci U S A 2001; 98:5140-5.
9. Rodes B, Toro C, Paxinos E, et al. Differences in disease progression in a cohort of long-term non-progressors after more than 16 years of HIV-1 infection. AIDS 2004; 18:1109-16.
10. Madec Y, Boufassa F, Rouzioux C, Delfraissy JF, Meyer L. Spontaneously controlled long-term viremia in HIV-1 seroconverters: an uncommon phenomenon? The SEROCO Study Group. Clin Infect Dis 2005; 40: 1350-4.
11. Meyer L, Magierowska M, Hubert JB, et al. Early protective effect of CCR-5 Δ32 heterozygosity on HIV-1 disease progression: relationship with viral load. The SEROCO Study Group. AIDS 1997; 11:F73-8.
12. + cell counts. J Infect Dis 2005; 192:46-55.
13. Lacabaratz-Porret C, Urrutia A, Doisne JM, et al. Impact of antiretroviral therapy and changes in virus load on human immunodeficiency virus (HIV)-specific T cell responses in primary HIV infection. J Infect Dis 2003; 187:748-57.
14. Williams CF, Klinzman D, Yamashita TE, et al. Persistent GB virus C infection and survival in HIV-infected men. N Engl J Med 2004; 350: 981-90.
15. + cell count and HIV-1 DNA level. AIDS 2004; 18:45-9.
16. + responses in HIV type 1-infected patients: comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapy. J Virol 1999; 73:7108-16.
17. + T cell proliferation. Proc Natl Acad Sci U S A 2001; 98:13878-83.
18. Trkola A. HIV-host interactions: vital to the virus and key to its inhibition. Curr Opin Microbiol 2004; 7:407-11.