Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapy

Journal of Clinical Immunology

Volumn 26, Issue 1, 2006, Pages 55-64

  Schmidt, Barbara ^a   Fujimura, Sue H ^a   Martin, Jeffrey N ^a   Levy, Jay A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiretroviral therapy; CD4+ cells; HIV infection; Myeloid dendritic cells; Plasmacytoid dendritic cells

Indexed keywords

ANTIVIRUS AGENT;

ADULT; ARTICLE; CELL COUNT; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DENDRITIC CELL; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; VIRUS LOAD;

ADULT; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; COHORT STUDIES; DENDRITIC CELLS; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MYELOID CELLS; PLASMA CELLS; VIRAL LOAD;

EID: 30944452875     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-006-8401-3     Document Type: Article

References (20)

1. Liu YJ: Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106(3):259-262, 2001
2. Siegal FP, Kadowaki N, Shodell M, et al.: The nature of the principal type 1 interferon-producing cells in human blood. Science 284(5421):1835-1837, 1999
3. Fitzgerald-Bocarsly P: Natural interferon-α producing cells: The plasmacytoid dendritic cells. Biotechniques 33:16-29, 2002
4. Levy JA, Scott I, Mackewicz C: Protection for HIV/AIDS: The importance of innate immunity. Clin Immunol 108:167-174, 2003
5. Donaghy H, Stebbing J, Petterson S: Antigen presentation and the role of dendritic cells in HIV. Curr Opin Infect Dis 17(1):1-6, 2004
6. Rissoan MC, Soumelis V, Kadowaki N, et al.: Reciprocal control of T helper cell and dendritic cell differentiation. Science 283(5405):1183-1186, 1999
7. Kadowaki N, Antonenko S, Lau JY, Liu YJ: Natural interferon α/β-producing cells link innate and adaptive immunity. J Exp Med 192(2):219-226, 2000
8. Pacanowski J, Kahi S, Baillet M, et al: Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection. Blood 98(10):3016-3021, 2001
9. Pacanowski J, Develioglu L, Kamga I, et al.: Early plasmacytoid dendritic cell changes predict plasma HIV load rebound during primary infection. J Infect Dis 190(10):1889-1892, 2004
10. Soumelis V, Scott I, Gheyas F, et al.: Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood 98:906-912, 2001
11. Grassi F, Hosmalin A, McIlroy D, Calvez V, Debre P, Autran B: Depletion in blood CD11c-positive dendritic cells from HIV-infected patients. AIDS 13:759-766, 1999
12. Feldman S, Stein D, Amrute S, et al.: Decreased interferon-α production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin Immunol 101(2):201-210, 2001
13. Donaghy H, Pozniak A, Gazzard B, et al.: Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 98(8):2574-2576, 2001
14. Chehimi J, Campbell DE, Azzoni L, et al.: Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J Immunol 168(9):4796-4801, 2002
15. Barron MA, Blyveis N, Palmer BE, MaWhinney S, Wilson CC: Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. J Infect Dis 187:26-37, 2003
16. Almeida M, Cordero M, Almeida J, Orfao A: Different subsets of peripheral blood dendritic cells show distinct phenotypic and functional abnormalities in HIV-1 infection. AIDS 19:261-271, 2005
17. Finke JS, Shodell M, Shah K, Siegal FP, Steinman RM: Dendritic cell numbers in the blood of HIV-1 infected patients before and after changes in antiretroviral therapy. J Clin Immunol 24(6):647-652, 2004
18. Mandy F, Nicholson J, Autran B, Janossy B: T-cell subset counting and the fight against AIDS: Reflections over a 20-year struggle. Cytometiy 50(2):39-45, 2002
19. Gratama JW, Kraan J, Keeney M, Granger V, Barnett D: Reduction of variation in T-cell subset enumeration among 55 laboratories using single-platform, three or four-color flow cytometry based on CD45 and SSC-based gating of lymphocytes. Cytometry 50(2):92-101, 2002
20. Levy JA: The importance of the innate immune system in controlling HIV infection and disease. Trends Immunol 22:312-316, 2001