Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice

Toxicology and Applied Pharmacology

Volumn 256, Issue 2, 2011, Pages 154-167

  Kopec, Anna K ^a,b   D'Souza, Michelle L ^a,b   Mets, Bryan D ^a   Burgoon, Lyle D ^a,b   Reese, Sarah E ^c   Archer, Kellie J ^c   Potter, Dave ^d   Tashiro, Colleen ^d   Sharratt, Bonnie ^d   Harkema, Jack R ^b   Zacharewski, Timothy R ^a,b  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d Canada N1G 3M5   (Canada)

Author keywords

Dose response; Gene expression; Liver; Mixture; Non additive interaction; PCB153; TCDD

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; LIPID; MONOUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; SESAME SEED OIL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; DOSE RESPONSE; DYSF GENE; FEEDING; FEMALE; GENE; GENE EXPRESSION; HEPATITIS; HISTOPATHOLOGY; LIPID ANALYSIS; LIVER; LIVER HYPERPLASIA; LIVER HYPERTROPHY; LIVER LEVEL; LIVER NECROSIS; LIVER WEIGHT; MOUSE; NONHUMAN; NQO1 GENE; PLA2G12A GENE; REAL TIME POLYMERASE CHAIN REACTION; SERPINB6A GENE; SRXN1 GENE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; FURANS; GENE EXPRESSION; LIVER; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYCHLORINATED BIPHENYLS; TETRACHLORODIBENZODIOXIN; THIOPHENES; TIME FACTORS; TRIGLYCERIDES;

ANIMALIA; MUS; SESAMUM INDICUM;

EID: 80053130505     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.08.002     Document Type: Article

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