Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57bl/6 mice

Toxicological Sciences

Volumn 118, Issue 1, 2010, Pages 286-297

  Kopec, Anna K ^a,b   Burgoon, Lyle D ^a,b   Ibrahim Aibo, Daher ^b   Burg, Ashley R ^a,b   Lee, Andrea W ^a,b   Tashiro, Colleen ^c   Potter, Dave ^c   Sharratt, Bonnie ^c   Harkema, Jack R ^b   Rowlands, J Craig ^d   Budinsky, Robert A ^d   Zacharewski, Timothy R ^a,b  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c Research Division   (Canada)

^d DOW CHEMICAL COMPANY   (United States)

Author keywords

Dose response; Mouse; PCB126; TCDD; TCDF; TEF

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 2,3,7,8 TETRACHLORODIBENZOFURAN; 3,3',4,4',5 PENTACHLOROBIPHENYL; ETHOXYRESORUFIN DEETHYLASE; SESAME SEED OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATION; C57BL 6 MOUSE; COMPARATIVE TOXICOLOGY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; GENOME ANALYSIS; GENOMICS; HISTOCHEMISTRY; HISTOPATHOLOGY; LIVER TOXICITY; MICROARRAY ANALYSIS; MODEL; MOUSE; NONHUMAN; TOXICOGENOMICS;

ANIMALS; BENZOFURANS; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION; LIGANDS; LIVER; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SIZE; OVARIECTOMY; POLYCHLORINATED BIPHENYLS; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TOXICOGENETICS;

MUS; SESAMUM INDICUM;

EID: 77958483338     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq236     Document Type: Article

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