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Volumn 61, Issue 5, 1998, Pages 557-568

The Ah receptor: A regulator of the biochemical and toxicological actions of structurally diverse chemicals

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CHOLINERGIC RECEPTOR; HALOGENATED HYDROCARBON; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN;

EID: 0032406634     PISSN: 00074861     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00002973     Document Type: Review
Times cited : (210)

References (45)
  • 2
    • 0026731745 scopus 로고
    • Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer
    • Bank PA, Yao EF, Phelps CL, Harper PA and Denison MS (1992) Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer. Eur J Pharm 258: 85-94.
    • (1992) Eur J Pharm , vol.258 , pp. 85-94
    • Bank, P.A.1    Yao, E.F.2    Phelps, C.L.3    Harper, P.A.4    Denison, M.S.5
  • 3
  • 4
    • 0026046412 scopus 로고
    • Aromatic hydrocarbon responsiveness-receptor agonists generated from indole3-carbinol in vitro and in vivo: Comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Bjeldanes LF, Kim J-L, Grose KR, Bartholomew JC and Bradfield CA (1991) Aromatic hydrocarbon responsiveness-receptor agonists generated from indole3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci 88: 9543-9547.
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 9543-9547
    • Bjeldanes, L.F.1    Kim, J.-L.2    Grose, K.R.3    Bartholomew, J.C.4    Bradfield, C.A.5
  • 6
    • 0030201065 scopus 로고    scopus 로고
    • Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: Implications for their carcinogenicity
    • Cheung Y-L, Snelling J, Mohammed NND, Gray TJB and Ioannides C (1996) Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity. Toxicol Appl Pharm 139: 203-211.
    • (1996) Toxicol Appl Pharm , vol.139 , pp. 203-211
    • Cheung, Y.-L.1    Snelling, J.2    Mohammed, N.N.D.3    Gray, T.J.B.4    Ioannides, C.5
  • 7
    • 0004058830 scopus 로고
    • Species variation in Ah receptor transformation and DNA binding
    • Gallo, MA, Scheuplein, RJ and Van Der Heijden, KA (eds) Banbury Report No. 35. Cold Spring Harbor Laboratory, Cold Spring Harbor Press, New York
    • Denison, MS, Phelps CL, DeHoog J, Kim HJ. Bank PA, Harper PA and Yao EF (1991) Species variation in Ah receptor transformation and DNA binding. In: Gallo, MA, Scheuplein, RJ and Van Der Heijden, KA (eds) Biological Basis of Risk Assessment of Dioxins and Related Compounds, Banbury Report No. 35. Cold Spring Harbor Laboratory, Cold Spring Harbor Press, New York, p 337.
    • (1991) Biological Basis of Risk Assessment of Dioxins and Related Compounds , pp. 337
    • Denison, M.S.1    DeHoog J, P.C.L.2    Kim, H.J.3    Bank, P.A.4    Harper, P.A.5    Yao, E.F.6
  • 8
    • 26444594002 scopus 로고    scopus 로고
    • Tryptamine and indole acetic acid are endogenous water soluble metabolites of tryptamine that are weak AhR ligands
    • Denison MS, Tullis K, Rogers WJ and Heath-Pagliuso S (1997) Tryptamine and indole acetic acid are endogenous water soluble metabolites of tryptamine that are weak AhR ligands. The Toxicologist, 6, 128.
    • (1997) The Toxicologist , vol.6 , pp. 128
    • Denison, M.S.1    Tullis, K.2    Rogers, W.J.3    Heath-Pagliuso, S.4
  • 9
    • 0023033162 scopus 로고
    • Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Species differences in molecular properties of the receptor from mouse and rat hepatic cytosol
    • Denison MS, Vella LM and Okey AB (1986) Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: species differences in molecular properties of the receptor from mouse and rat hepatic cytosol. J Biol Chem 261: 3987-3995.
    • (1986) J Biol Chem , vol.261 , pp. 3987-3995
    • Denison, M.S.1    Vella, L.M.2    Okey, A.B.3
  • 10
    • 0029118476 scopus 로고
    • Xenobiotic-inducible transcription of cytochrome P450 genes
    • Denison MS and Whitlock JP, Jr (1995) Xenobiotic-inducible transcription of cytochrome P450 genes. J Biol Chem 270: 18175-18178.
    • (1995) J Biol Chem , vol.270 , pp. 18175-18178
    • Denison, M.S.1    Whitlock Jr., J.P.2
  • 11
    • 0002094410 scopus 로고
    • Toxicology of dioxins and related chemicals
    • A. Schecter, (ed) Plenum Press, New York
    • Devito MJ and Birnbaum LS (1994) Toxicology of dioxins and related chemicals. In: A. Schecter, (ed) Dioxins and Health, Plenum Press, New York p 139.
    • (1994) Dioxins and Health , pp. 139
    • Devito, M.J.1    Birnbaum, L.S.2
  • 12
    • 0030245635 scopus 로고    scopus 로고
    • Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity
    • Fernandez-Salguero P, Hilbert D, Rudikoff S, Ward J and Gonzalez F (1996) Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol Appl Pharm 140: 173-179.
    • (1996) Toxicol Appl Pharm , vol.140 , pp. 173-179
    • Fernandez-Salguero, P.1    Hilbert, D.2    Rudikoff, S.3    Ward, J.4    Gonzalez, F.5
  • 14
    • 0030582844 scopus 로고    scopus 로고
    • Analysis of structural requirements for Ah receptor antagonist activity: Ellipticines, flavones, and related compounds
    • Gasiewicz TA. Kende AS, Rucci G, Whitney B and Willey JJ (1996) Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds. Biochem Pharm 52: 1787-1803.
    • (1996) Biochem Pharm , vol.52 , pp. 1787-1803
    • Gasiewicz, T.A.1    Kende, A.S.2    Rucci, G.3    Whitney, B.4    Willey, J.J.5
  • 15
    • 0002477760 scopus 로고
    • Dioxins, dibenzofurans, PCBs and wildlife
    • A. Schecter (ed) Plenum Press, New York
    • Giesy JP, Ludwig JP and Tillitt DE (1994) Dioxins, dibenzofurans, PCBs and wildlife. In: A. Schecter (ed) Dioxins and Health, Plenum Press, New York p 249.
    • (1994) Dioxins and Health , pp. 249
    • Giesy, J.P.1    Ludwig, J.P.2    Tillitt, D.E.3
  • 16
    • 0027295906 scopus 로고
    • Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver
    • Gillner M, Bergman J, Cambillau C, Alexandersson M, Fernstrom B and Gustafsson J-A (1993) Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Molec Pharm 44: 336-345.
    • (1993) Molec Pharm , vol.44 , pp. 336-345
    • Gillner, M.1    Bergman, J.2    Cambillau, C.3    Alexandersson, M.4    Fernstrom, B.5    Gustafsson, J.-A.6
  • 17
    • 0030005152 scopus 로고    scopus 로고
    • Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat
    • Gradelet S, Astorg P, Leclerc J, Chevalier J, Vemevaut, M-F and Siess M-H (1996) Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat. Xenobiotics 6: 49-63.
    • (1996) Xenobiotics , vol.6 , pp. 49-63
    • Gradelet, S.1    Astorg, P.2    Leclerc, J.3    Chevalier, J.4    Vemevaut, M.-F.5    Siess, M.-H.6
  • 18
    • 84950433390 scopus 로고
    • Morphological deformities in brown bullheads administered dietary β-naphthoflavone
    • Grady AW, Fabacher DL, Frame G and Steadman BL (1992) Morphological deformities in brown bullheads administered dietary β-naphthoflavone. J Aquat Animal Health 4: 7-16
    • (1992) J Aquat Animal Health , vol.4 , pp. 7-16
    • Grady, A.W.1    Fabacher, D.L.2    Frame, G.3    Steadman, B.L.4
  • 19
    • 0028334079 scopus 로고
    • Photoaffinity labeling of the Ah receptor: Phylogenetic survey of diverse vertebrate and invertebrate species
    • Hahn ME, Poland A, Glover E and Stegeman JJ (1994) Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species. Arch Biochem Biophys 310: 218-228.
    • (1994) Arch Biochem Biophys , vol.310 , pp. 218-228
    • Hahn, M.E.1    Poland, A.2    Glover, E.3    Stegeman, J.J.4
  • 20
    • 0028987872 scopus 로고
    • The aryl hydrocarbon receptor complex
    • Hankinson O (1995) The aryl hydrocarbon receptor complex. Ann Rev Pharm Toxicol 35: 307-340.
    • (1995) Ann Rev Pharm Toxicol , vol.35 , pp. 307-340
    • Hankinson, O.1
  • 22
    • 0025836981 scopus 로고
    • Photooxidized products of tryptophan can act as dioxin agonists
    • Helferich W and Denison MS (1991) Photooxidized products of tryptophan can act as dioxin agonists. Molec Pharm 40: 674-678.
    • (1991) Molec Pharm , vol.40 , pp. 674-678
    • Helferich, W.1    Denison, M.S.2
  • 23
    • 0027299699 scopus 로고
    • Relationship between aryl hydrocarbon receptor binding, induction of aryl hydrocarbon hydroxylase and 7-ethyoxyresorufin o-deethylase enzymes and toxic activities of aromatic xenobiotics in animals. a new model
    • Kafafi SA, Afeefy HY, Said HK and Kafafi AG (1993) Relationship between aryl hydrocarbon receptor binding, induction of aryl hydrocarbon hydroxylase and 7-ethyoxyresorufin o-deethylase enzymes and toxic activities of aromatic xenobiotics in animals. A new model. Chem Res Toxicol 6: 328-334.
    • (1993) Chem Res Toxicol , vol.6 , pp. 328-334
    • Kafafi, S.A.1    Afeefy, H.Y.2    Said, H.K.3    Kafafi, A.G.4
  • 24
    • 0024560836 scopus 로고
    • 2-(4′-Chlorophenyl) benzothiazole is a potent inducer of cytochrome P4501A1 in a human and a mouse cell line
    • Karenlampi SO, Tuome K, Korkalainen M and Raunio H (1989) 2-(4′-Chlorophenyl) benzothiazole is a potent inducer of cytochrome P4501A1 in a human and a mouse cell line. J Biochem 181: 143-148.
    • (1989) J Biochem , vol.181 , pp. 143-148
    • Karenlampi, S.O.1    Tuome, K.2    Korkalainen, M.3    Raunio, H.4
  • 25
    • 0030588279 scopus 로고    scopus 로고
    • Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: Evidences of a human-specific signal transduction pathway for CYP1A1 induction
    • Kikuchi H, Kato H, Mizuno M, Hossain A, Ikawa S, Miyazaki J. and Watanabe M (1996) Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: evidences of a human-specific signal transduction pathway for CYP1A1 induction. Arch Biochem Biophys 334: 235-240.
    • (1996) Arch Biochem Biophys , vol.334 , pp. 235-240
    • Kikuchi, H.1    Kato, H.2    Mizuno, M.3    Hossain, A.4    Ikawa, S.5    Miyazaki, J.6    Watanabe, M.7
  • 26
    • 0026693657 scopus 로고
    • In vitro activation of the dioxin receptor to a DNA-binding form by food-borne heterocyclic amines
    • Kleman MI, Overvik E, Mason GGF and Gustafsson J-A (1992) In vitro activation of the dioxin receptor to a DNA-binding form by food-borne heterocyclic amines. Carcin. 13: 1619-1624.
    • (1992) Carcin. , vol.13 , pp. 1619-1624
    • Kleman, M.I.1    Overvik, E.2    Mason, G.G.F.3    Gustafsson, J.-A.4
  • 27
    • 0027451607 scopus 로고
    • Stuctural requirements of the induction of hepatic microsomal cytochrome P450 by imidazole- And pyridine-containing compounds in rats
    • Kobayashi Y, Matsuura Y, Kotani E, Fukuda T, Aoyagi T, Tobinaga S, Yoshida T and Kuroiwa Y (1993) Stuctural requirements of the induction of hepatic microsomal cytochrome P450 by imidazole- and pyridine-containing compounds in rats. J Biochem 114: 697-701.
    • (1993) J Biochem , vol.114 , pp. 697-701
    • Kobayashi, Y.1    Matsuura, Y.2    Kotani, E.3    Fukuda, T.4    Aoyagi, T.5    Tobinaga, S.6    Yoshida, T.7    Kuroiwa, Y.8
  • 31
    • 0029963257 scopus 로고    scopus 로고
    • The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin
    • Ma Q and Whitlock JP Jr. (1996) The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Molec Cell Biol 16: 2144-2150.
    • (1996) Molec Cell Biol , vol.16 , pp. 2144-2150
    • Ma, Q.1    Whitlock Jr., J.P.2
  • 32
    • 0031002895 scopus 로고    scopus 로고
    • A Novel Cytoplasmic Protein That Interacts with the Ah Receptor, Contains Tetratricopeptide Repeat Motifs, and Augments the Transcriptional Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
    • Ma Q and Whitlock JP Jr. (1997) A Novel Cytoplasmic Protein That Interacts with the Ah Receptor, Contains Tetratricopeptide Repeat Motifs, and Augments the Transcriptional Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. J Biol Chem 14: 8878-8884.
    • (1997) J Biol Chem , vol.14 , pp. 8878-8884
    • Ma, Q.1    Whitlock Jr., J.P.2
  • 34
    • 0026355818 scopus 로고
    • Production of Ah receptor ligands in rat fecal suspensions containing tryptophan or indole-3-carbinol
    • Perdew GH and Babbs CF (1991) Production of Ah receptor ligands in rat fecal suspensions containing tryptophan or indole-3-carbinol. Nutr Cancer 16: 209-218.
    • (1991) Nutr Cancer , vol.16 , pp. 209-218
    • Perdew, G.H.1    Babbs, C.F.2
  • 35
    • 0027533906 scopus 로고
    • Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: Transcriptional activation of the human CYP1A1 gene
    • Quattrochi LC and Tukey RH (1993) Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. Molec Pharm 43: 504-508.
    • (1993) Molec Pharm , vol.43 , pp. 504-508
    • Quattrochi, L.C.1    Tukey, R.H.2
  • 36
    • 0029418619 scopus 로고
    • Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands
    • Rannug U, Rannug A, Sjoberg U, Li H, Westerhold R and Bergman A (1995) Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Curr Biol 2: 841-845.
    • (1995) Curr Biol , vol.2 , pp. 841-845
    • Rannug, U.1    Rannug, A.2    Sjoberg, U.3    Li, H.4    Westerhold, R.5    Bergman, A.6
  • 37
    • 0028116593 scopus 로고
    • Suspension-mediated induction of hepa1c1c7 CYP1a-1 expression is dependent on the Ah receptor signal transduction pathway
    • Sadek CM and Allen-Hoffman BL (1994) Suspension-mediated induction of hepa1c1c7 CYP1a-1 expression is dependent on the Ah receptor signal transduction pathway. J Biol Chem 269: 31505-31509.
    • (1994) J Biol Chem , vol.269 , pp. 31505-31509
    • Sadek, C.M.1    Allen-Hoffman, B.L.2
  • 38
    • 0024997614 scopus 로고
    • Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs)
    • Safe S (1990) Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 21: 51-88.
    • (1990) Crit Rev Toxicol , vol.21 , pp. 51-88
    • Safe, S.1
  • 39
    • 0029118684 scopus 로고
    • Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds
    • Safe S (1995) Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharm Therap 67: 247-281.
    • (1995) Pharm Therap , vol.67 , pp. 247-281
    • Safe, S.1
  • 40
    • 0030015421 scopus 로고    scopus 로고
    • Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development
    • Schmidt J, Su G, Reddy J, Simon, M. and Bradfield, C. (1996) Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci 93: 6731-6736.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 6731-6736
    • Schmidt, J.1    Su, G.2    Reddy, J.3    Simon, M.4    Bradfield, C.5
  • 41
    • 0022918456 scopus 로고
    • The interaction of 1,3-diaryltriazenes with the Ah receptor
    • Sweatlock JA and Gasiewicz TA (1986) The interaction of 1,3-diaryltriazenes with the Ah receptor. Chemosphere 15: 1687-1690.
    • (1986) Chemosphere , vol.15 , pp. 1687-1690
    • Sweatlock, J.A.1    Gasiewicz, T.A.2
  • 42
    • 0028978788 scopus 로고
    • Three-dimensional quantitative structure-activity relationships of dioxins and dioxin-like compounds: Model validation and Ah receptor characterization
    • Waller CL and McKinney JD (1995) Three-dimensional quantitative structure-activity relationships of dioxins and dioxin-like compounds: model validation and Ah receptor characterization. Chem Res Toxicol 8: 847-858.
    • (1995) Chem Res Toxicol , vol.8 , pp. 847-858
    • Waller, C.L.1    McKinney, J.D.2
  • 44
    • 0001459262 scopus 로고    scopus 로고
    • Complementation of Ah receptor deficiency in hepatoma cells: Negative feedback regulation and cell cycle control by the Ah receptor
    • Weiss C, Kolluri SK, Kiefer F and Gottlicher M (1996) Complementation of Ah receptor deficiency in hepatoma cells: negative feedback regulation and cell cycle control by the Ah receptor. Exper Cell Res 226: 154-163.
    • (1996) Exper Cell Res , vol.226 , pp. 154-163
    • Weiss, C.1    Kolluri, S.K.2    Kiefer, F.3    Gottlicher, M.4


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