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Volumn 366, Issue 1580, 2011, Pages 2918-2928

Crystal structure of an RNA polymerase ribozyme in complex with an antibody fragment

Author keywords

Antibody; Ligase ribozyme; RNA world

Indexed keywords

ANTIBODY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVITY; POLYMERIZATION; PROTEIN; THREE-DIMENSIONAL MODELING;

EID: 80052946333     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2011.0144     Document Type: Review
Times cited : (9)

References (52)
  • 1
    • 0003604405 scopus 로고    scopus 로고
    • (eds), Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Joyce, G. F. & Orgel, L. E. (eds) 1999 The RNA world. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
    • (1999) The RNA World
    • Joyce, G.F.1    Orgel, L.E.2
  • 2
    • 0035906978 scopus 로고    scopus 로고
    • RNA-catalyzed RNA polymerization: Accurate and general RNA-templated primer extension
    • (doi:10.1126/science.1060786)
    • Johnston, W. K., Unrau, P. J., Lawrence, M. S., Glasner, M. E. & Bartel, D. P. 2001 RNA-catalyzed RNA polymerization: accurate and general RNA-templated primer extension. Science 292, 1319-1325. (doi:10.1126/science.1060786)
    • (2001) Science , vol.292 , pp. 1319-1325
    • Johnston, W.K.1    Unrau, P.J.2    Lawrence, M.S.3    Glasner, M.E.4    Bartel, D.P.5
  • 3
    • 23644440503 scopus 로고    scopus 로고
    • New ligase-derived RNA polymerase ribozymes
    • (doi:10.1261/rna.2110905)
    • Lawrence, M. S. & Bartel, D. P. 2005 New ligase-derived RNA polymerase ribozymes. RNA 11, 1173-1180. (doi:10.1261/rna.2110905)
    • (2005) RNA , vol.11 , pp. 1173-1180
    • Lawrence, M.S.1    Bartel, D.P.2
  • 4
    • 34250860849 scopus 로고    scopus 로고
    • Selection of an improved RNA polymerase ribozyme with superior extension and fidelity
    • (doi:10.1261/rna.548807)
    • Zaher, H. S. & Unrau, P. J. 2007 Selection of an improved RNA polymerase ribozyme with superior extension and fidelity. RNA 13, 1017-1026. (doi:10.1261/rna.548807)
    • (2007) RNA , vol.13 , pp. 1017-1026
    • Zaher, H.S.1    Unrau, P.J.2
  • 5
    • 0027488624 scopus 로고
    • Isolation of new ribozymes from a large pool of random sequences (see comment)
    • (doi:10.1126/science.7690155)
    • Bartel, D. P. & Szostak, J. W. 1993 Isolation of new ribozymes from a large pool of random sequences (see comment). Science 261, 1411-1418. (doi:10.1126/ science.7690155)
    • (1993) Science , vol.261 , pp. 1411-1418
    • Bartel, D.P.1    Szostak, J.W.2
  • 6
    • 0029147392 scopus 로고
    • Structurally complex and highly active RNA ligases derived from random RNA sequences
    • (doi:10.1126/science.7618102)
    • Ekland, E. H., Szostak, J. W. & Bartel, D. P. 1995 Structurally complex and highly active RNA ligases derived from random RNA sequences. Science 269, 364-370. (doi:10.1126/science.7618102)
    • (1995) Science , vol.269 , pp. 364-370
    • Ekland, E.H.1    Szostak, J.W.2    Bartel, D.P.3
  • 7
    • 78650986853 scopus 로고    scopus 로고
    • A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination
    • (doi:10.1038/nsmb.1945)
    • Koldobskaya, Y. et al. 2011 A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat. Struct. Mol. Biol. 18, 100-106. (doi:10.1038/nsmb.1945)
    • (2011) Nat. Struct. Mol. Biol , vol.18 , pp. 100-106
    • Koldobskaya, Y.1
  • 8
    • 0030901131 scopus 로고    scopus 로고
    • Continuous in vitro evolution of catalytic function
    • (doi:10.1126/science.276.5312.614)
    • Wright, M. C. & Joyce, G. F. 1997 Continuous in vitro evolution of catalytic function. Science 276, 614-617. (doi:10.1126/science.276.5312.614)
    • (1997) Science , vol.276 , pp. 614-617
    • Wright, M.C.1    Joyce, G.F.2
  • 9
    • 3042732096 scopus 로고    scopus 로고
    • Directed evolution of nucleic acid enzymes
    • (doi:10.1146/annurev.biochem.73.011303.073717)
    • Joyce, G. F. 2004 Directed evolution of nucleic acid enzymes. Annu. Rev. Biochem. 73, 791-836. (doi:10.1146/annurev.biochem.73.011303.073717)
    • (2004) Annu. Rev. Biochem , vol.73 , pp. 791-836
    • Joyce, G.F.1
  • 10
    • 0030927266 scopus 로고    scopus 로고
    • RNA structure: Crystal clear?
    • (doi:10.1016/S0959-440X(97)80045-0)
    • Doudna, J. A. & Cate, J. H. 1997 RNA structure: crystal clear? Curr. Opin. Struct. Biol. 7, 310-316. (doi:10.1016/ S0959-440X(97)80045-0)
    • (1997) Curr. Opin. Struct. Biol , vol.7 , pp. 310-316
    • Doudna, J.A.1    Cate, J.H.2
  • 11
    • 0037394662 scopus 로고    scopus 로고
    • 2003RNAcrystallization
    • (doi:10.1016/S1047-8477(03)00042-X)
    • Golden, B. L. & Kundrot, C. E. 2003RNAcrystallization. J. Struct. Biol. 142, 98. (doi:10.1016/S1047-8477(03)00042-X)
    • J. Struct. Biol , vol.142 , pp. 98
    • Golden, B.L.1    Kundrot, C.E.2
  • 12
    • 80052942773 scopus 로고    scopus 로고
    • Determining structures of RNA aptamers and riboswitches by X-ray crystallography
    • (doi:10.1007/978-1-59745-557-2_9)
    • Edwards, A. L., Garst, A. D. & Batey, R. T. 2009 Determining structures of RNA aptamers and riboswitches by X-ray crystallography. Nucleic Acid Pept. Aptamers 535, 1-29. (doi:10.1007/978-1-59745-557-2_9)
    • (2009) Nucleic Acid Pept. Aptamers , vol.535 , pp. 1-29
    • Edwards, A.L.1    Garst, A.D.2    Batey, R.T.3
  • 13
    • 4344596976 scopus 로고    scopus 로고
    • Crystallization of RNA and RNA-protein complexes
    • (doi:10.1016/j.ymeth.2004.03.027)
    • Ke, A. & Doudna, J. A. 2004 Crystallization of RNA and RNA-protein complexes. Methods 34, 408-414. (doi:10.1016/j.ymeth.2004.03.027)
    • (2004) Methods , vol.34 , pp. 408-414
    • Ke, A.1    Doudna, J.A.2
  • 14
    • 0032511181 scopus 로고    scopus 로고
    • A general module for RNA crystallization
    • (doi:10.1006/jmbi.1998.1789)
    • Ferre-D'Amare, A. R., Zhou, K. & Doudna, J. A. 1998 A general module for RNA crystallization. J. Mol. Biol. 279, 621-631. (doi:10.1006/jmbi.1998.1789)
    • (1998) J. Mol. Biol , vol.279 , pp. 621-631
    • Ferre-D'Amare, A.R.1    Zhou, K.2    Doudna, J.A.3
  • 15
    • 69449089715 scopus 로고    scopus 로고
    • Determining structures of RNA aptamers and riboswitches by X-ray crystallography
    • Edwards, A. L., Garst, A. D. & Batey, R. T. 2009 Determining structures of RNA aptamers and riboswitches by X-ray crystallography. Methods Mol. Biol. 535, 135-163.
    • (2009) Methods Mol. Biol , vol.535 , pp. 135-163
    • Edwards, A.L.1    Garst, A.D.2    Batey, R.T.3
  • 16
    • 3042538806 scopus 로고    scopus 로고
    • Selenium derivatization and crystallization of DNA and RNA oligonucleotides for X-ray crystallography using multiple anomalous dispersion
    • (doi:10.1093/nar/gkh325)
    • Carrasco, N., Buzin, Y., Tyson, E., Halpert, E. & Huang, Z. 2004 Selenium derivatization and crystallization of DNA and RNA oligonucleotides for X-ray crystallography using multiple anomalous dispersion. Nucl. Acids Res. 32, 1638-1646. (doi:10.1093/nar/gkh325)
    • (2004) Nucl. Acids Res , vol.32 , pp. 1638-1646
    • Carrasco, N.1    Buzin, Y.2    Tyson, E.3    Halpert, E.4    Huang, Z.5
  • 17
    • 24144485941 scopus 로고    scopus 로고
    • Syntheses of RNAs with up to 100 nucleotides containing site-specific 20-methylseleno labels for use in X-ray crystallography
    • (doi:10.1021/ja051694k)
    • Hobartner, C., Rieder, R., Kreutz, C., Puffer, B., Lang, K., Polonskaia, A., Serganov, A. & Micura, R. 2005 Syntheses of RNAs with up to 100 nucleotides containing site-specific 20-methylseleno labels for use in X-ray crystallography. J. Am. Chem. Soc. 127, 12 035-12 045. (doi:10.1021/ja051694k)
    • (2005) J. Am. Chem. Soc , vol.127
    • Hobartner, C.1    Rieder, R.2    Kreutz, C.3    Puffer, B.4    Lang, K.5    Polonskaia, A.6    Serganov, A.7    Micura, R.8
  • 18
    • 34447260753 scopus 로고    scopus 로고
    • A general strategy to solve the phase problem in RNA crystallography
    • (doi:10.1016/j.str.2007.06.003)
    • Keel, A. Y., Rambo, R. P., Batey, R. T. & Kieft, J. S. 2007 A general strategy to solve the phase problem in RNA crystallography. Structure 15, 761-772. (doi:10.1016/j.str.2007.06.003)
    • (2007) Structure , vol.15 , pp. 761-772
    • Keel, A.Y.1    Rambo, R.P.2    Batey, R.T.3    Kieft, J.S.4
  • 19
    • 45749105933 scopus 로고    scopus 로고
    • A general method for phasing novel complexRNA crystal structures without heavy-atom derivatives
    • (doi:10.1107/S0907444908011578)
    • Robertson, M. P. & Scott, W. G. 2008 A general method for phasing novel complexRNA crystal structures without heavy-atom derivatives. Acta Crystallogr. D Biol. Crystallogr. D64, 738-744. (doi:10.1107/S0907444908011578)
    • (2008) Acta Crystallogr. D Biol. Crystallogr , vol.D64 , pp. 738-744
    • Robertson, M.P.1    Scott, W.G.2
  • 20
    • 0034695419 scopus 로고    scopus 로고
    • Crystallization and structure determination of a hepatitis delta virus ribozyme: Use of the RNA-binding protein U1A as a crystallization module
    • (doi:10.1006/jmbi.1999.3398)
    • Ferre-D'Amare, A. R. & Doudna, J. A. 2000 Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module. J. Mol. Biol. 295, 541-556. (doi:10.1006/jmbi.1999.3398)
    • (2000) J. Mol. Biol , vol.295 , pp. 541-556
    • Ferre-D'Amare, A.R.1    Doudna, J.A.2
  • 21
    • 0032497521 scopus 로고    scopus 로고
    • Crystal structure of a hepatitis delta virus ribozyme
    • (doi:10.1038/26912)
    • Ferré-D'Amaré, A. R., Zhou, K. & Doudna, J. A. 1998 Crystal structure of a hepatitis delta virus ribozyme. Nature 395, 567-574. (doi:10.1038/26912)
    • (1998) Nature , vol.395 , pp. 567-574
    • Ferré-D'Amaré, A.R.1    Zhou, K.2    Doudna, J.A.3
  • 22
    • 69249107262 scopus 로고    scopus 로고
    • Engineering of recombinant crystallization chaperones
    • (doi:10.1016/j.sbi.2009.04.008)
    • Koide, S. 2009 Engineering of recombinant crystallization chaperones. Curr. Opin. Struct. Biol. 19, 449-457. (doi:10.1016/j.sbi.2009.04.008)
    • (2009) Curr. Opin. Struct. Biol , vol.19 , pp. 449-457
    • Koide, S.1
  • 23
    • 0037122805 scopus 로고    scopus 로고
    • X-ray structure of a ClC chloride channel at 3.0Å reveals the molecular basis of anion selectivity
    • (doi:10.1038/415287a)
    • Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T. & MacKinnon, R. 2002 X-ray structure of a ClC chloride channel at 3.0Å reveals the molecular basis of anion selectivity. Nature 415, 287-294. (doi:10.1038/415287a)
    • (2002) Nature , vol.415 , pp. 287-294
    • Dutzler, R.1    Campbell, E.B.2    Cadene, M.3    Chait, B.T.4    Mackinnon, R.5
  • 24
    • 46449122768 scopus 로고    scopus 로고
    • Toward chaperone-assisted crystallography: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold
    • (doi:10.1110/ps.034892.108)
    • Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S. & Kossiakoff, A. A. 2008 Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Protein Sci. 17, 1175-1187. (doi:10.1110/ps.034892.108)
    • (2008) Protein Sci , vol.17 , pp. 1175-1187
    • Tereshko, V.1    Uysal, S.2    Koide, A.3    Margalef, K.4    Koide, S.5    Kossiakoff, A.A.6
  • 25
    • 0028890031 scopus 로고
    • Structure at 2.8Å resolution of cytochrome c oxidase from Paracoccus denitrificans
    • (doi:10.1038/376660a0)
    • Iwata, S., Ostermeier, C., Ludwig, B. & Michel, H. 1995 Structure at 2.8Å resolution of cytochrome c oxidase from Paracoccus denitrificans. Nature 376, 660-669. (doi:10.1038/376660a0)
    • (1995) Nature , vol.376 , pp. 660-669
    • Iwata, S.1    Ostermeier, C.2    Ludwig, B.3    Michel, H.4
  • 26
    • 69249107262 scopus 로고    scopus 로고
    • Engineering of recombinant crystallization chaperones
    • (doi:10.1016/j.sbi.2009.04.008)
    • Koide, S. 2009 Engineering of recombinant crystallization chaperones. Curr. Opin. Struct. Biol. 19, 449-457. (doi:10.1016/j.sbi.2009.04.008)
    • (2009) Curr. Opin. Struct. Biol , vol.19 , pp. 449-457
    • Koide, S.1
  • 27
    • 33646352962 scopus 로고    scopus 로고
    • Potent antibody therapeutics by design
    • (doi:10.1038/nri1837)
    • Carter, P. J. 2006 Potent antibody therapeutics by design. Nat. Rev. Immunol. 6, 343-357. (doi:10.1038/nri1837)
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 343-357
    • Carter, P.J.1
  • 28
    • 33645056478 scopus 로고    scopus 로고
    • Antibody targeted drugs as cancer therapeutics
    • (doi:10.1038/nrd1957)
    • Schrama, D., Reisfeld, R. A. & Becker, J. C. 2006 Antibody targeted drugs as cancer therapeutics. Nat. Rev. Drug Discov. 5, 147-159. (doi:10.1038/nrd1957)
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 147-159
    • Schrama, D.1    Reisfeld, R.A.2    Becker, J.C.3
  • 29
    • 0025666859 scopus 로고
    • Anti-(U1) small nuclear RNA antibodies in anti-small nuclear ribonucleoprotein sera from patients with connective tissue diseases
    • (doi:10.1172/JCI114954)
    • van Venrooij, W. J., Hoet, R., Castrop, J., Hageman, B., Mattaj, I. W. & van de Putte, L. B. 1990 Anti-(U1) small nuclear RNA antibodies in anti-small nuclear ribonucleoprotein sera from patients with connective tissue diseases. J. Clin. Invest. 86, 2154-2160. (doi:10.1172/JCI114954)
    • (1990) J. Clin. Invest , vol.86 , pp. 2154-2160
    • van Venrooij, W.J.1    Hoet, R.2    Castrop, J.3    Hageman, B.4    Mattaj, I.W.5    van de Putte, L.B.6
  • 30
    • 0027255253 scopus 로고
    • Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs
    • (doi:10.1073/pnas.90.14.6781)
    • Gilliam, A. C. & Steitz, J. A. 1993 Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs. Proc. Natl Acad. Sci. USA 90, 6781-6785. (doi:10.1073/pnas.90.14.6781)
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6781-6785
    • Gilliam, A.C.1    Steitz, J.A.2
  • 31
    • 0019404351 scopus 로고
    • Antibodies against double-stranded RNA in patients with rheumatoid arthritis, osteoarthrosis and Paget's disease of bone
    • (doi:10.1111/j.1445-5994.1981.tb04227.x)
    • Kalmakoff, J., Maskill, W. J., Thongkrajai, P. & Palmer, D. G. 1981 Antibodies against double-stranded RNA in patients with rheumatoid arthritis, osteoarthrosis and Paget's disease of bone. Aust. N. Z. J. Med. 11, 173-178. (doi:10.1111/j.1445-5994.1981.tb04227.x)
    • (1981) Aust. N. Z. J. Med , vol.11 , pp. 173-178
    • Kalmakoff, J.1    Maskill, W.J.2    Thongkrajai, P.3    Palmer, D.G.4
  • 32
    • 0031747470 scopus 로고    scopus 로고
    • Anti-transfer RNA antibodies in two patients with pulmonary fibrosis, Raynaud's phenomenon and polyarthritis
    • (doi:10.1007/BF01452262)
    • Ohosone, Y., Matsumura, M., Chiba, J., Nagaoka, S., Matsuoka, Y., Irimajiri, S. & Mimori, T. 1998 Anti-transfer RNA antibodies in two patients with pulmonary fibrosis, Raynaud's phenomenon and polyarthritis. Clin. Rheumatol. 17, 144-147. (doi:10.1007/BF01452262)
    • (1998) Clin. Rheumatol , vol.17 , pp. 144-147
    • Ohosone, Y.1    Matsumura, M.2    Chiba, J.3    Nagaoka, S.4    Matsuoka, Y.5    Irimajiri, S.6    Mimori, T.7
  • 33
    • 0024853122 scopus 로고
    • Immunoprecipitation of ribonucleoproteins using autoantibodies
    • [32] (doi:10.1016/0076-6879(89)80118-1)
    • Steitz, J. A. 1989 [32] Immunoprecipitation of ribonucleoproteins using autoantibodies. Methods Enzymol. 180, 468-481. (doi:10.1016/0076-6879(89)80118-1)
    • (1989) Methods Enzymol , vol.180 , pp. 468-481
    • Steitz, J.A.1
  • 34
    • 34848848421 scopus 로고    scopus 로고
    • High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries
    • (doi:10.1016/j.jmb.2007.08.005)
    • Fellouse, F. A. et al. 2007 High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. J. Mol. Biol. 373, 924-940. (doi:10.1016/j.jmb.2007.08.005)
    • (2007) J. Mol. Biol , vol.373 , pp. 924-940
    • Fellouse, F.A.1
  • 35
    • 34249852867 scopus 로고    scopus 로고
    • High-affinity single-domain binding proteins with a binary-code interface
    • (doi:10.1073/pnas.0700149104)
    • Koide, A., Gilbreth, R. N., Esaki, K., Tereshko, V. & Koide, S. 2007 High-affinity single-domain binding proteins with a binary-code interface. Proc. Natl Acad. Sci. USA 104, 6632-6637. (doi:10.1073/pnas.0700149104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6632-6637
    • Koide, A.1    Gilbreth, R.N.2    Esaki, K.3    Tereshko, V.4    Koide, S.5
  • 37
    • 43749108590 scopus 로고    scopus 로고
    • Submitting antibodies to binding arbitration
    • (doi:10.1038/nchembio0608-326)
    • Michnick, S. W. & Sidhu, S. S. 2008 Submitting antibodies to binding arbitration. Nat. Chem. Biol. 4, 326-329. (doi:10.1038/nchembio0608-326)
    • (2008) Nat. Chem. Biol , vol.4 , pp. 326-329
    • Michnick, S.W.1    Sidhu, S.S.2
  • 39
    • 4344714933 scopus 로고    scopus 로고
    • Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
    • (doi:10.1073/pnas.0401786101)
    • Fellouse, F. A., Wiesmann, C. & Sidhu, S. S. 2004 Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition. Proc. Natl Acad. Sci. USA 101, 12 467-12 472. (doi:10.1073/pnas.0401786101)
    • (2004) Proc. Natl Acad. Sci. USA , vol.101
    • Fellouse, F.A.1    Wiesmann, C.2    Sidhu, S.S.3
  • 40
    • 0015247402 scopus 로고
    • Attempts to locate complementarity- determining residues in the variable positions of light and heavy chains
    • (doi:10.1111/j.1749-6632.1971.tb13550.x)
    • Kabat, E. A. & Wu, T. T. 1971 Attempts to locate complementarity- determining residues in the variable positions of light and heavy chains. Ann. N. Y. Acad. Sci. 190, 382-393. (doi:10.1111/j.1749-6632.1971.tb13550.x)
    • (1971) Ann. N. Y. Acad. Sci , vol.190 , pp. 382-393
    • Kabat, E.A.1    Wu, T.T.2
  • 41
    • 65749099472 scopus 로고    scopus 로고
    • The importance of being tyrosine: Lessons in molecular recognition from minimalist synthetic binding proteins
    • (doi:10.1021/cb800314v)
    • Koide, S. & Sidhu, S. S. 2009 The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins. ACS Chem. Biol. 4, 325-334. (doi:10.1021/cb800314v)
    • (2009) ACS Chem. Biol , vol.4 , pp. 325-334
    • Koide, S.1    Sidhu, S.S.2
  • 42
    • 0027173193 scopus 로고
    • An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme
    • (doi:10.1021/bi00071a003)
    • Murphy, F. L. & Cech, T. R. 1993 An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme. Biochemistry 32, 5291-5300. (doi:10.1021/bi00071a003)
    • (1993) Biochemistry , vol.32 , pp. 5291-5300
    • Murphy, F.L.1    Cech, T.R.2
  • 43
    • 0029820625 scopus 로고    scopus 로고
    • Crystal structure of a group I ribozyme domain: Principles of RNA packing
    • (doi:10.1126/science.273.5282.1678)
    • Cate, J. H., Gooding, A. R., Podell, E., Zhou, K., Golden, B. L., Kundrot, C. E., Cech, T. R. & Doudna, J. A. 1996 Crystal structure of a group I ribozyme domain: principles of RNA packing. Science 273, 1678-1685. (doi:10.1126/science.273.5282.1678)
    • (1996) Science , vol.273 , pp. 1678-1685
    • Cate, J.H.1    Gooding, A.R.2    Podell, E.3    Zhou, K.4    Golden, B.L.5    Kundrot, C.E.6    Cech, T.R.7    Doudna, J.A.8
  • 44
    • 0035085466 scopus 로고    scopus 로고
    • Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA- solvent interactions
    • (doi:10.1016/S0969-2126(01)00579-2)
    • Juneau, K., Podell, E., Harrington, D. J. & Cech, T. R. 2001 Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA- solvent interactions. Structure 9, 221-231. (doi:10.1016/S0969-2126(01)00579-2)
    • (2001) Structure , vol.9 , pp. 221-231
    • Juneau, K.1    Podell, E.2    Harrington, D.J.3    Cech, T.R.4
  • 45
    • 70849121359 scopus 로고    scopus 로고
    • Crystal structure of the catalytic core of an RNA-polymerase ribozyme
    • (doi:10.1126/science.1174676)
    • Shechner, D.M., Grant, R. A., Bagby, S.C., Koldobskaya, Y., Piccirilli, J. A. & Bartel, D. P. 2009 Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science 326, 1271-1275. (doi:10.1126/science.1174676)
    • (2009) Science , vol.326 , pp. 1271-1275
    • Shechner, D.M.1    Grant, R.A.2    Bagby, S.C.3    Koldobskaya, Y.4    Piccirilli, J.A.5    Bartel, D.P.6
  • 46
    • 73349118813 scopus 로고    scopus 로고
    • + dependence: Selection, sequence analysis, and identification of functional tertiary interactions
    • (doi:10.1261/rna.1912509)
    • + dependence: selection, sequence analysis, and identification of functional tertiary interactions. RNA 15, 2129-2146. (doi:10.1261/rna.1912509)
    • (2009) RNA , vol.15 , pp. 2129-2146
    • Bagby, S.C.1    Bergman, N.H.2    Shechner, D.M.3    Yen, C.4    Bartel, D.P.5
  • 48
    • 0029837557 scopus 로고    scopus 로고
    • Two-metal ion catalysis in enzymatic acyl- and phosphoryl-transfer reactions
    • (doi:10.1002/anie.199620241)
    • Sträter, N., Lipscomb, W. N., Klabunde, T. & Krebs, B. 1996 Two-metal ion catalysis in enzymatic acyl- and phosphoryl-transfer reactions. Angew. Chem. Int. Ed. Engl. 35, 2024-2055. (doi:10.1002/anie.199620241)
    • (1996) Angew. Chem. Int. Ed. Engl , vol.35 , pp. 2024-2055
    • Sträter, N.1    Lipscomb, W.N.2    Klabunde, T.3    Krebs, B.4
  • 49
    • 67749098066 scopus 로고    scopus 로고
    • Protein-free small nuclear RNAs catalyze a twostep splicing reaction
    • (doi:10.1073/pnas.0902020106)
    • Valadkhan, S., Mohammadi, A., Jaladat, Y. & Geisler, S. 2009 Protein-free small nuclear RNAs catalyze a twostep splicing reaction. Proc. Natl Acad. Sci. USA 106, 11 901-11 906. (doi:10.1073/pnas.0902020106)
    • (2009) Proc. Natl Acad. Sci. USA , vol.106
    • Valadkhan, S.1    Mohammadi, A.2    Jaladat, Y.3    Geisler, S.4
  • 50
    • 0035909314 scopus 로고    scopus 로고
    • Splicing-related catalysis by protein-free snRNAs
    • (doi:10.1038/35099500)
    • Valadkhan, S. & Manley, J. L. 2001 Splicing-related catalysis by protein-free snRNAs. Nature 413, 701-707. (doi:10.1038/35099500)
    • (2001) Nature , vol.413 , pp. 701-707
    • Valadkhan, S.1    Manley, J.L.2
  • 51
    • 34249098371 scopus 로고    scopus 로고
    • A guanine nucleobase important for catalysis by the VS ribozyme
    • (doi:10.1038/sj.emboj.7601698)
    • Wilson, T. J., McLeod, A. C. & Lilley, D. M. 2007 A guanine nucleobase important for catalysis by the VS ribozyme. EMBO J. 26, 2489-2500. (doi:10.1038/sj.emboj.7601698)
    • (2007) EMBO J , vol.26 , pp. 2489-2500
    • Wilson, T.J.1    McLeod, A.C.2    Lilley, D.M.3
  • 52
    • 78751487465 scopus 로고    scopus 로고
    • Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental data
    • (doi:10.1261/rna.2473711)
    • Wilson, T. J. & Lilley, D. M. 2011 Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental data. RNA 17, 213-221. (doi:10.1261/rna.2473711)
    • (2011) RNA , vol.17 , pp. 213-221
    • Wilson, T.J.1    Lilley, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.