Geriatric epilepsy: Research and clinical directions for the future

Epilepsy and Behavior

Volumn 22, Issue 1, 2011, Pages 103-111

  Roberson, Erik D ^a,b   Hope, Omotola A ^c   Martin, Roy C ^a   Schmidt, Dieter ^d  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d Epilepsy Research Group   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CARBAMAZEPINE; ETIRACETAM; GABAPENTIN; GE 2270A; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; TAU PROTEIN; TOPIRAMATE; VALPROIC ACID;

AFRICAN AMERICAN; AGE; AGED; ALZHEIMER DISEASE; ANTICONVULSANT THERAPY; ARTERIAL WALL THICKNESS; ATAXIA; ATHEROSCLEROSIS; BRAIN TUMOR; CAROTID ARTERY; CEREBROVASCULAR DISEASE; COGNITION; COGNITIVE DEFECT; DEMENTIA; DISEASE ASSOCIATION; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG WITHDRAWAL; EPILEPSY; EPILEPTIC DISCHARGE; FALLING; GENDER; HISPANIC; HUMAN; LIFESTYLE; LOW DRUG DOSE; MAINTENANCE DRUG DOSE; MARRIAGE; MEDICAL RESEARCH; MIGRAINE; NEUROPATHIC PAIN; NONHUMAN; OSTEOLYSIS; PROTEIN FUNCTION; RACE; REVIEW; SEIZURE; SIDE EFFECT; SUSTAINED RELEASE FORMULATION; TREATMENT WITHDRAWAL; VASCULAR DISEASE;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; COGNITION DISORDERS; EPILEPSY; GERIATRICS; HUMANS; TAU PROTEINS;

EID: 80052505890     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2011.04.005     Document Type: Review

References (117)

1. Brodie M.J., Elder A.T., Kwan P. Epilepsy in later life. Lancet Neurol 2009, 8:1019-1030.
2. Werthan K.J. Epilepsy in the elderly. Dtsch Arztebl Int 2009, 106:135-142.
3. Baker G.A., Jacoby A., Buck D., et al. The quality of life of older people with epilepsy: findings from a UK community study. Seizure 2001, 10:92-99.
4. McLaughlin D.P., Pachana N.A., McFarland K. Stigma, seizure frequency and quality of life: the impact of epilepsy in late adulthood. Seizure 2008, 17:281-287.
5. Loiseau J., Loiseau P., Guyot M., et al. Survey of seizure disorders in the French southwest. Epilepsia 1990, 31:391-396.
6. Hauser W.A., Annegers J.F., Kurtland L.T. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993, 34:453-468.
7. Stegmayr B., Asplund K., Wester P.O. Trends in incidence, case-fatality rate, and severity of stroke in northern Sweden, 1985-1991. Stroke 1994, 25:1738-1745.
8. Forsgren L., Bucht G., Eriksson S., Bergmark L. Incidence and clinical characterization of unprovoked seizures in adults: a prospective population-based study. Epilepsia 1996, 37:224-229.
9. Annegers J.F., Hauser W., Coan S.P., Rocca W.A. A population-based study of seizures after traumatic brain injury. N Engl J Med 1998, 338:20-24.
10. Hesdorffer D.C., Hauser W., Annegers J.F., et al. Dementia and adult-onset unprovoked seizures. Neurology 1996, 46:727-730.
11. Rowan A.J., Ramsay R., Collins J.F., et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005, 64:1868-1873.
12. Sillanpaa M., Shinnar S. Long term mortality in childhood-onset epilepsy. N Engl J Med 2010, 363:2522-2529.
13. Rowan A.J. What we owe our seniors with epilepsy: thoughts on quality of life. Epilepsy Res 2000, 1:215-216.
14. Hermann B., Seidenberg M., Sager M., et al. Growing old with epilepsy: the neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsy. Epilepsia 2008, 49:731-740.
15. Martin R.C., Griffith H.R., Faught E., et al. Cognitive functioning in community dwelling older adults with chronic partial epilepsy. Epilepsia 2005, 46:298-303.
16. Griffith H.R., Martin R.C., Bambara J.K., et al. Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairment. Epilepsy Behav 2006, 8:161-168.
17. Piazzini A., Canevini P., Turner K., et al. Elderly people and epilepsy: cognitive function. Epilepsia 2006, 47(Suppl. 5):S82-S84.
18. Hermann B., Seidenberg M., Dow C., et al. Cognitive prognosis in chronic temporal lobe epilepsy. Ann Neurol 2006, 60:80-87.
19. Cordonnier C., Henon H., Derambure P., et al. Early epileptic seizures after stroke are associated with increased risk of new onset dementia. J Neurol Neurosurg Psychiatry 2007, 78:514-516.
20. De Reuck J., Nagy E., Van Maele G. Seizures and epilepsy in patients with lacunar strokes. J Neurol Sci 2007, 263:75-78.
21. Hommet C., Mondon K., Camus V., et al. Epilepsy and dementia in the elderly. Dementia Geriatr Cogn Disord 2008, 25:293-300.
22. Jacoby A. Epilepsy and stigma: an update and critical review. Curr Neurol Neurosci Rep 2008, 8:339-344.
23. Elliott J.O., Lu B., Moore J.L., et al. Exercise, diet, health behaviors and risk factors among persons with epilepsy based on the California Health Interview Schedule. Epilepsy Behav 2008, 13:307-315.
24. Lempert T., Bauer M., Schmidt D. Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. Ann Neurol 1994, 36:233-237.
25. Ramsay R., Rowan A.J., Pryor F.M. Special considerations in treating the elderly patient with epilepsy. Neurology 2004, 62:S24-S29.
26. Kellinghaus C., Loddenkemper T., Dinner D.S., et al. Seizure semiology in the elderly: a video analysis. Epilepsia 2004, 45:263-267.
27. Wolkove N., Elkholy O., Baltzan M., Palayen M. Sleep and aging: 1. Sleep disorders commonly found in older people. Can Med Assoc J 2007, 176:1299-1304.
28. Derry C.P., Duncan J.S., Berkovic S.F. Paroxysmal motor disorders of sleep: the clinical spectrum and differentiation from epilepsy. Epilepsia 2006, 47:1775-1791.
29. Elger C.E., Schmidt D. Modern management of epilepsy: a practical approach. Epilepsy Behav 2008, 12:501-539.
30. Saetre E., Perucca E., Isojarvi J., et al. An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy. Epilepsia 2007, 48:1292-1302.
31. Brodie M.J., Overstall P.W., Giorgi L. Multicentre, double-blind randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. Epilepsy Res 1999, 37:81-87. for the TULES Group.
32. Giorgi L., Gomez G., O'Neill F., et al. The tolerability of lamotrigine in elderly patients with epilepsy. Drugs Aging 2001, 18:621-630.
33. Kutluay E., McCague K., D'Souza J., Beydoun A. Safety and tolerability of oxcarbazepine in elderly patients with epilepsy. Epilepsy Behav 2003, 4:175-189.
34. Ferrendelli J.A., French J., Leppik I.E., et al. Use of levetiracetam in a population of patients aged 65years and older: a subset analysis of the KEEPER trial. Epilepsy Behav 2003, 4:702-709.
35. Alsaadi T.M., Koopmans S., Apperson M., Farias S. Levetiracetam monotherapy for elderly patients with epilepsy. Seizure 2004, 13:58-60.
36. Garcia-Escriva A., Lopez-Hernandez N. The use of levetiracetam in monotherapy in post stroke seizures in the elderly population. Rev Neurol 2007, 45:523-525.
37. Belcastro V., Costa C., Galletti F., et al. Levetiracetam in newly diagnosed late-onset post-stroke seizures: a prospective observational study. Epilepsy Res 2008, 83:223-226.
38. Ramsay R., Uthman B., Pryor F.M., et al. Topiramate in older patients with partial-onset seizures: a pilot double-blind, dose-comparison study. Epilepsia 2008, 49:1180-1185.
39. Groselj J., Guerrini R., van Oene J., et al. Experience with topiramate in elderly patients with recent onset epilepsy. Acta Neurol Scand 2005, 112:144-150.
40. Pugh M.J., van Cott A.C., Knofel J.E., et al. Trends in antiepileptic drug prescribing for older patients with new-onset epilepsy. Neurology 2008, 70:2171-2178.
41. Mattson R., Cramer J.A., Collins J.F., et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985, 313:145-151.
42. Smith D.B., Mattson R., Cramer J.A., et al. Results of a Nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, and primidone. Epilepsia 1987, 28:S50-S58.
43. Ramsay R., Rowan A.J., Slater J.D. Effect of age on epilepsy and its treatment: results from the VA Cooperative Study. Epilepsia 1994, 35:91A.
44. Cloyd J., Lackner T.E., Leppik I.E. Antiepileptics in the elderly: pharmacoepidemiology and pharmacokinetics. Arch Fam Med 1994, 3:589-598.
45. Petty S.J., O'Brien T.J., Wark J.D. Anti-epileptic medication and bone health. Osteoporosis Int 2007, 18:129-142.
46. Ensrud K.E., Blackwell T.L., Mangione C.M., et al. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 2002, 50:1629-1637.
47. Bohannon A.D., Hanlon J.T., Landerman R., Gold D.T. Association of race and other potential risk factors with nonvertebral fractures in community-dwelling elderly women. Am J Epidemiol 1999, 149:1002-1009.
48. Birnbaum A., Hardie N.A., Leppik I.E., et al. Variability of total phenytoin serum concentrations within elderly nursing home residents. Neurology 2003, 60:555-559.
49. Pugh M.J., VanCott A.C., Steinman M.A., et al. Choice of initial antiepileptic drug for older veterans: possible pharmacokinetic drug interactions with existing medications. J Am Geriatr Soc 2010, 58:465-471.
50. Murphy M., Smith P.D., Wood M., et al. Surgery for temporal lobe epilepsy associated with mesial temporal sclerosis in the older patient: a long-term follow-up. Epilepsia 2010, 51:1024-1029.
51. Grivas A., Schramm J., Kral T., et al. Surgical treatment for refractory temporal lobe epilepsy in the elderly: seizure outcome and neuropsychological sequelae compared with a younger cohort. Epilepsia 2006, 47:1364-1372.
52. Boling W, Andermann F, Reutens D, Dubeau F, Caporicci L, Olivier A Surgery for temporal lobe epilepsy in older patients. J Neurosurg 2001, 95:242-248.
53. Rausch R., Kraemer S., Pietras C.J., et al. Early and late cognitive changes following temporal lobe surgery for epilepsy. Neurology 2003, 60:951-959.
54. Seidenberg M., Pulsipher D.T., Hermann B. Cognitive progression in epilepsy. Neuropsychol Rev 2007, 17:445-454.
55. Pugh M.J., Knoefel J.E., Mortensen E.M., et al. New-onset epilepsy risk factors in older veterans. J Am Geriatr Soc 2009, 57:237-242.
56. Gaitatzis A., Carroll K., Majeed A., Sander J.W. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia 2004, 45:1613-1622.
57. Téllez-Zenteno J.F., Matijevic S., Wiebe S. Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia 2005, 46:1955-1962.
58. Gouras G.K., Relkin N.R., Sweeney D., et al. Increased apolipoprotein E å4 in epilepsy with senile plaques. Ann Neurol 1997, 41:402-404.
59. Mackenzie I.R., Miller L.A. Senile plaques in temporal lobe epilepsy. Acta Neuropathol 1994, 87:504-510.
60. Griffith H.R., Martin R.C., Bambara J.K., et al. Cognitive functioning over 3years in community dwelling older adults with chronic partial epilepsy. Epilepsy Res 2007, 74:91-96.
61. Palop J.J., Mucke L. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 2009, 66:435-440.
62. Larner A.J., Doran M. Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene. J Neurol 2006, 253:139-158.
63. Amatniek J.C., Hauser W.A., DelCastillo-Castaneda C., et al. Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia 2006, 47:867-872.
64. Romanelli M.F., Morris J.C., Ashkin K., Coben L.A. Advanced Alzheimer's disease is a risk factor for late-onset seizures. Arch Neurol 1990, 47:847-850.
65. Hauser W.A., Morris M.L., Heston L.L., Anderson V.E. Seizures and myoclonus in patients with Alzheimer's disease. Neurology 1986, 36:1226-1230.
66. Palop J.J., Mucke L. Amyloid-β-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nature Neurosci 2010, 13:812-818.
67. Puzzo D., Privitera L., Leznik E., et al. Picomolar amyloid-β positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 2008, 28:14537-14545.
68. Abramov E., Dolev I., Fogel H., et al. Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses. Nature Neurosci 2009, 12:1567-1576.
69. Hsieh H., Boehm J., Sato C., et al. AMPAR removal underlies AB-induced synaptic depression and dendritic spine loss. Neuron 2006, 52:831-843.
70. Kamenetz F., Tomita T., Hsieh H., et al. APP processing and synaptic function. Neuron 2003, 37:925-937.
71. Shankar G.M., Bloodgood B.L., Townsend M., et al. Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 2007, 27:2866-2875.
72. Cirrito J.R., Yamada K.A., Finn M.B., et al. Synaptic activity regulates interstitial fluid amyloid-β levels in vivo. Neuron 2005, 48:913-922.
73. Cirrito J.R., Kang J.E., Lee J., et al. Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo. Neuron 2008, 58:42-51.
74. Hsiao K.K., Borchelt D.R., Olson K., et al. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 1995, 15:1203-1218.
75. LaFerla F.M., Tinkle B.T., Bieberich C.J., et al. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nature Genet 1995, 9:21-30.
76. Moechars D., Dewachter I., Lorent K., et al. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 1999, 274:6483-6492.
77. Kumar-Singh S., Dewachter I., Moechars D., et al. Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation. Neurobiol Dis 2000, 7:9-22.
78. Lalonde R., Dumont M., Staufenbiel M., Strazielle C. Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen. Behav Brain Res 2005, 157:91-98.
79. Minkeviciene R., Rheims S., Dobszay M.B., et al. Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci 2009, 29:3453-3462.
80. Cheng I., Scearce-Levie K., Legleiter J., et al. Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem 2007, 282:23818-23828.
81. Palop J., Jones B., Kekonius L., et al. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci USA 2003, 100:9572-9577.
82. Palop J.J., Chin J., Roberson E.D., et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007, 55:697-711.
83. Palop J.J., Chin J., Bien-Ly N., et al. Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice. J Neurosci 2005, 25:9686-9693.
84. Chin J., Palop J.J., Puoliväli J., et al. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci 2005, 25:9694-9703.
85. Roberson E.D., Scearce-Levie K., Palop J.J., et al. Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 2007, 316:750-754.
86. Ittner L.M., Ke Y.D., Delerue F., et al. Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell 2010, 142:387-397.
87. Roberson E.D., Halabisky B., Yoo J.W., et al. Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci 2011, 31:700-711.
88. Gómez de Barreda E., Pérez M., Gómez Ramos P., et al. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis 2010, 37:622-629.
89. Oddo S., Billings L., Kesslak J.P., et al. Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 2004, 43:321-332.
90. Lewis J., Dickson D.W., Lin W.L., et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 2001, 293:1487-1491.
91. Meilandt W.J., Yu G.Q., Chin J., et al. Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci 2008, 28:5007-5017.
92. Pacheco C.D., Elrick M.J., Lieberman A.P. Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Hum Mol Genet 2009, 18:956-965.
93. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 2002, 298:789-791.
94. Busche M.A., Eichhoff G., Adelsberger H., et al. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science 2008, 321:1686-1689.
95. Andrews-Zwilling Y., Bien-Ly N., Xu Q., et al. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci 2010, 30:13707-13717.
96. de Waal H., Stam C.J., Blankenstein M.A., et al. EEG abnormalities in early and late onset Alzheimer's disease: understanding heterogeneity. Neurol Neurosurg Psychiatry 2011, 82:67-71.
97. Palop J.J., Mucke L., Roberson E.D. Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling. Methods Mol Biol 2011, 670:245-262.
98. Committee on the Quality of Health Care in America Crossing the quality chasm: a new health system for the 21st century March 21, 2001, Institute of Medicine of the National Academies.
99. Leppik I.E. Introduction to the International Geriatric Epilepsy Symposium (IGES). Epilepsy Res 2006, 68:S1-S4.
100. Stephen L.J., Brodie M.J. Epilepsy in elderly people. Lancet 2000, 355:1441-1446.
101. Pugh M.J., Cramer J.A., Knoefel J.E., et al. Potentially inappropriate antiepileptic drugs for elderly patients with epilepsy. J Am Geriatr Soc 2004, 52:417-422.
102. Pugh M.J., Foreman P.J., Berlowitz D.R. Prescibing antiepileptics for the elderly: differences between guideline recommendations and clinical practice. Drugs Aging 2006, 23:861-875.
103. Bokhour B.G., Pugh M.J., Rao J.K., et al. Improving methods for measuring quality of care: a patient-centered approach in chronic disease. Med Care Res Rev 2009, 66:147-166.
104. Hope O.A., Zeber J.E., Kressin N.R., et al. New-onset geriatric epilepsy care: race, setting of diagnosis, and choice of antiepileptic drug. Epilepsia 2009, 50:1085-1093.
105. Hauser W.A. Epidemiology of seizures and epilepsy in the elderly 1997, Butterworth-Heinemann, Newton, MA.
106. Sillanpaa M., Kalviainen R., Kalaukka T., et al. Temporal changes in the incidence of epilepsy in Finland: nationwide study. Epilepsy Res 2006, 71:206-215.
107. Rowan A.J. Epilepsy in older adults: common morbidities influence development, treatment strategies, and expected outcomes. Geriatrics 2005, 60:30.
108. Morley J.E. A fall is a major event in the life of an older person. J Gerontol Biol Sci Med Sci 2002, 57:M492-M495.
109. Löscher W., Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011, 52:657-678.
110. Hussain S.A., Haut S.R., Lipton R.B., et al. Incidence of epilepsy in a racially diverse, community-dwelling, elderly cohort: results from the Einstein aging study. Epilepsy Res 2006, 71:195-205.
111. Karceski S., Morrell M.J., Carpenter D. Treatment of epilepsy in adults: expert opinion. Epilepsy Behav 2005, 7:S1-S64.
112. Semah F., Picot M.-C., Derambure P., et al. The choice of antiepileptic drugs in newly diagnosed epilepsy: a national French survey. Epileptic Disord 2004, 6:255-264.
113. Ensrud K.E., Walczak T., Blackwell T.L., et al. Antiepileptic drug use increases rates of bone loss in older women. Neurology 2004, 62:2051-2057.
114. Lackner T.E., Cloyd J., Thomas L.W., Leppik I.E. Antiepileptic drug use in nursing home residents: effect of age, gender, and comedication on pattern use. Epilepsia 1998, 39:1083-1087.
115. Pugh M., Berlowitz D.R., Montouris G., et al. What constitutes high quality of care for adults with epilepsy?. Neurology 2007, 69:2020-2027.
116. Fountain N.B., Van Ness P.C., Swain-Eng R., et al. Quality improvement in neurology: AAN epilepsy quality measures. Report of the Quality Measurement and Reporting Subcommittee of the American Academy of Neurology. Neurology 2011, 76:94-99.
117. Fattouch J., Di Bonaventura C., Casciato S., et al. Intravenous levetiracetam as first-line treatment of status epilepticus in the elderly. Acta Neurol Scand 2010, 121:418-421.