Antiepileptic drug use increases rates of bone loss in older women: A prospective study

Neurology

Volumn 62, Issue 11, 2004, Pages 2051-2057

  Ensrud, K E ^a,b,f   Walczak, T S ^c   Blackwell, T ^e   Ensrud, E R ^d   Bowman, P J ^b   Stone, K L ^e  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d Noran Neurological Clinic   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; PHENYTOIN;

AGED; ARTICLE; BONE DENSITY; BONE MINERAL; CALCANEUS; CONTROLLED STUDY; DRUG USE; FEMALE; FOLLOW UP; HIP; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; OSTEOLYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY;

EID: 2942562767     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000125185.74276.D2     Document Type: Article

References (35)

1. Ensrud KE, Blackwell TL, Mangione CM, et al. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 2002;50:1629-1637.
2. Ensrud KE, Blackwell TL, Mangione CM, et al. Central nervous system-active medications and risk for fractures in older women. Arch Intern Med 2003;163:949-957.
3. Tannirandorn P, Epstein S. Drug-induced bone loss. Osteoporos Int 2000;11:637-659.
4. Dent CE, Richens A, Rowe DJ, Stamp TC. Osteomalacia with long-term anticonvulsant therapy in epilepsy. Br Med J 1970;4:69-72.
5. Farhat G, Yamout B, Mikati MA, Demirjian S, Sawaya R, Fuleihan GE. Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology 2002;58:1348-1353.
6. Sato Y, Kondo I, Ishida S, et al. Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology 2001;57:445-449.
7. Stephen LJ, McLellan AR, Harrison JH, et al. Bone density and antiepileptic drugs: a case controlled study. Seizure 1999;8:339-342.
8. Valimaki MJ, Tiihonen M, Laitinen K, et al. Bone mineral density measured by dual-energy x-ray absorptiometry and novel markers of bone formation and resorption in patients on antiepileptic drugs. J Bone Miner Res 1994;9:631-637.
9. Cummings SR, Black DM, Nevitt MC, et al., for the Study of Osteoporotic Fractures Research Group. Appendicular bone density and age predict hip fracture in women. JAMA 1990;263:665-668.
10. Veterans Affairs Medication Classification System. In: United States Pharmacopeia dispensing information (USPDI), vol. 1, appendix VII. 22nd ed. Greenwood Village, CO: Micromedix Thompson Healthcare, 2002:3033-3050.
11. Steiger P, Cummings SR, Black DM, Spencer NE, Genant HK. Age-related decrements in bone mineral density in women over 65. J Bone Miner Res 1992;7:625-632.
12. Ensrud KE, Palermo L, Black DM, et al. Hip and calcaneal bone loss increase with advancing age: longitudinal results from the study of osteoporotic fractures. J Bone Miner Res 1995;10:1778-1787.
13. Cummings SR, Block G, McHenry K, et al. Evaluation of two food frequency methods of measuring dietary calcium intake. Am J Epidemiol 1987;126:796-802.
14. Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clin Gerontol 1986;5:165-173.
15. Lohman TG, Roche AF, Mavtorell R. Anthropometric standardization reference manual. Champaign, IL: Human Kinetics Books, 1988:177.
16. Nevitt MC, Johnell O, Black DM, Ensrud KE, Genant HK, Cummings SR. Bone mineral density predicts non-spine fractures in very elderly women. Osteoporosis Int 1994;4:325-331.
17. Kubota F, Kifune A, Shibata N, et al. Bone mineral density of epileptic patients on long-term antiepileptic drug therapy: a quantitative digital radiography study. Epilepsy Res 1999;33:93-97.
18. Andress DL, Ozuna J, Tirschwell D, et al. Antiepileptic drug-induced bone loss in young male patients who have seizures. Arch Neurol 2002;59:781-786.
19. Bohannon AD, Hanlon JT, Landerman R, Gold DT. Association of race and other potential risk factors with nonvertebral fractures in community-dwelling elderly women. Am J Epidemiol 1999;149:1002-1009.
20. Vestergaard P, Tigaran S, Rejnmark L, et al. Fracture risk is increased in epilepsy. Acta Neurol Scand 1999;99:269-275.
21. Cummings SR, Nevitt MC, Browner WS, et al., for the Study of Osteoporotic Fractures Research Group. Risk factors for hip fracture in white women. N Engl J Med 1995;332:767-773.
22. Heller HJ, Sakhaee K. Anticonvulsant-induced bone disease. Arch Neurol 2001;58:1352-1353.
23. Wasnich RD, Ross PD, Vogel JM, Davis JW. Bone mineral measurements. In: Osteoporosis critique and practicum. Honolulu: Banyan Press, 1989:125.
24. Hahn TJ, Birge SJ, Scarp CR, Avioli LV. Phenobarbital-induced alterations in vitamin D metabolism. J Clin Invest 1972;51:741-748.
25. Weinstein RS, Bryce GF, Sappington LJ, King DW, Gallagher BB. Decreased serum ionized calcium and normal vitamin D metabolite levels with anticonvulsant drug treatment. J Clin Endocrinol Metab 1984;58:1003-1009.
26. Bell RD, Pak CYC, Zersekh J, Barilla DE, Vaski M. Effect of phenytoin on bone and vitamin D metabolism. Ann Neurol 1979;5:374-378.
27. Verrotti A, Greco R, Latini G, Morgese G, Chiarelli F. Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine. Epilepsia 2002;43:1488-1492.
28. Ohta T, Wergedal J, Gruber H, Baylink D, Lau K-HW. Low dose phenytoin is an osteogenic agent in the rat. Calcif Tissue Int 1995;56:42-48.
29. Nakade O, Baylink DJ, Lau K-HW. Phenytoin at micromolar concentrations is an osteogenic agent for human-mandible-derived bone cells in vitro. J Dent Res. 1995;74:331-337.
30. Feldkamp J, Becker A, Witte OW, Scharif D, Scherbaum WA. Long-term anticonvulsant therapy leads to low bone mineral density-evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells. Exp Clin Endocrinol Diabetes 2000;108:37-43.
31. Isojarvi JI, Pakarinen AJ, Ylipalosaari PJ, Myllyla VV. Serum hormones in male epileptic patients receiving anticonvulsant medication. Arch Neurol 1990;47:670-676.
32. Hauser WA. Epidemiology of seizures in the elderly. In: Rowan AJ, Ramsey RE, eds. Seizures and epilepsy in the elderly. Boston: Butterworth-Heinemann, 1997:7-20.
33. Lackner TE. Strategies for optimizing antiepileptic drug therapy in elderly people. Pharmacotherapy 2002;22:329-364.
34. Looker AC, Orwoll ES, Johnston CC, et al. Prevalence of low femoral bone density in older U. S. adults from NHANES III. J Bone Miner Res 1997;12:1761-1771.
35. Valmadrid C, Voorhees C, Litt B, Schneyer CR. Practice patterns of neurologists regarding bone and mineral effects of antiepileptic drug therapy. Arch Neurol 2001;58:1369-1374.