Variants in the FTO gene are associated with common obesity in the Belgian population

Molecular Genetics and Metabolism

Volumn 93, Issue 4, 2008, Pages 481-484

  Peeters, Armand ^a   Beckers, Sigri ^a   Verrijken, An ^a   Roevens, Peter ^b   Peeters, Pieter ^b   Van Gaal, Luc ^a   Van Hul, Wim ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Association; FTO; Obesity

Indexed keywords

ADULT; ARTICLE; BODY FAT; COMPARATIVE STUDY; CONTROLLED STUDY; FTO GENE; GENE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BELGIUM; BODY MASS INDEX; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; VARIATION (GENETICS);

EID: 40749094439     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2007.10.011     Document Type: Article

References (8)

1. Frayling T.M., Timpson N.J., Weedon M.N., Zeggini E., Freathy R.M., Lindgren C.M., Perry J.R., Elliott K.S., Lango H., Rayner N.W., Shields B., Harries L.W., Barrett J.C., Ellard S., Groves C.J., Knight B., Patch A.M., Ness A.R., Ebrahim S., Lawlor D.A., Ring S.M., Ben-Shlomo Y., Jarvelin M.R., Sovio U., Bennett A.J., Melzer D., Ferrucci L., Loos R.J., Barroso I., Wareham N.J., Karpe F., Owen K.R., Cardon L.R., Walker M., Hitman G.A., Palmer C.N., Doney A.S., Morris A.D., Smith G.D., Hattersley A.T., and McCarthy M.I. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316 (2007) 889-894
2. Dina C., Meyre D., Gallina S., Durand E., Korner A., Jacobson P., Carlsson L.M., Kiess W., Vatin V., Lecoeur C., Delplanque J., Vaillant E., Pattou F., Ruiz J., Weill J., Levy-Marchal C., Horber F., Potoczna N., Hercberg S., Le Stunff C., Bougneres P., Kovacs P., Marre M., Balkau B., Cauchi S., Chevre J.C., and Froguel P. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 39 (2007) 724-726
3. Scuteri A., Sanna S., Chen W.M., Uda M., Albai G., Strait J., Najjar S., Nagaraja R., Orru M., Usala G., Dei M., Lai S., Maschio A., Busonero F., Mulas A., Ehret G.B., Fink A.A., Weder A.B., Cooper R.S., Galan P., Chakravarti A., Schlessinger D., Cao A., Lakatta E., and Abecasis G.R. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3 (2007) e115
4. Lukaski H.C., Johnson P.E., Bolonchuk W.W., and Lykken G.I. Assessment of fat-free mass using bioelectrical impedance measurements of the human body. Am. J. Clin. Nutr. 41 (1985) 810-817
5. Deurenberg P., Weststrate J.A., and Hautvast J.G. Changes in fat-free mass during weight loss measured by bioelectrical impedance and by densitometry. Am. J. Clin. Nutr. 49 (1989) 33-36
6. Van der Kooy K., and Seidell J.C. Techniques for the measurement of visceral fat: a practical guide. Int. J. Obes. Relat. Metab. Disord. 17 (1993) 187-196
7. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16 (1988) 1215
8. Skol A.D., Scott L.J., Abecasis G.R., and Boehnke M. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat. Genet. 38 (2006) 209-213