Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication

PLoS Computational Biology

Volumn 7, Issue 8, 2011, Pages

  Gandhi, Vishal V ^a   Samuels, David C ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME KINETICS; KINETICS; RATE CONSTANTS; SALVAGING;

COMPUTATIONAL MODELLING; DEOXYRIBONUCLEOSIDES; DEOXYRIBONUCLEOTIDES; DIPHOSPHATES; DNA REPLICATIONS; ENZYMES KINETICS; MITOCHONDRIAL DNA; SALVAGE ENZYMES; SALVAGE PATHWAY; TRIPHOSPHATE;

SUBSTRATES;

ADENOSINE TRIPHOSPHATE; DEOXYRIBONUCLEOSIDE DIPHOSPHATE; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DEOXYRIBONUCLEOTIDE; GUANOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; PYROPHOSPHATE; RIBONUCLEOTIDE; UNCLASSIFIED DRUG; DEOXYRIBONUCLEOSIDE;

ANALYTIC METHOD; ARTICLE; CATALYSIS; CELL CYCLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MITOCHONDRIAL DNA REPLICATION; NUCLEOTIDE METABOLISM; PHOSPHORYLATION; SIMULATION; BIOLOGY; BIOSYNTHESIS; COMPUTER SIMULATION; DNA REPLICATION; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DEOXYRIBONUCLEOSIDES; DEOXYRIBONUCLEOTIDES; DNA REPLICATION; DNA, MITOCHONDRIAL; KINETICS; MITOCHONDRIA;

EID: 80052337913     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002078     Document Type: Article

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